NRP2 and VEGFA

Number of citations of the paper that reports this interaction (PubMedID 10748121)
0

Data Source:
HPRD (in vivo)

		NRP2	VEGFA
Description		neuropilin 2	vascular endothelial growth factor A
Image
GO Annotations	Cellular Component	Semaphorin Receptor Complex Extracellular Region Plasma Membrane Membrane Axon Postsynaptic Membrane Glutamatergic Synapse	Extracellular Region Extracellular Space Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Adherens Junction Cell Surface Membrane Secretory Granule Extracellular Matrix Platelet Alpha Granule Lumen VEGF-A Complex
	Molecular Function	Vascular Endothelial Growth Factor Receptor Activity Protein Binding Heparin Binding Semaphorin Receptor Activity Growth Factor Binding Cytokine Binding Signaling Receptor Activity Identical Protein Binding Metal Ion Binding	Fibronectin Binding Cytokine Activity Platelet-derived Growth Factor Receptor Binding Vascular Endothelial Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Neuropilin Binding Chemoattractant Activity Identical Protein Binding Protein Homodimerization Activity Vascular Endothelial Growth Factor Receptor 1 Binding Vascular Endothelial Growth Factor Receptor 2 Binding Receptor Ligand Activity Extracellular Matrix Binding
	Biological Process	Angiogenesis Neuron Migration Positive Regulation Of Endothelial Cell Proliferation Outflow Tract Septum Morphogenesis Cell Adhesion Nervous System Development Axon Guidance Heart Development Positive Regulation Of Endothelial Cell Migration Facial Nerve Structural Organization Trigeminal Nerve Structural Organization Vestibulocochlear Nerve Structural Organization Nerve Development Branchiomotor Neuron Axon Guidance Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Cell Differentiation Trunk Neural Crest Cell Migration Ventral Trunk Neural Crest Cell Migration Vascular Endothelial Growth Factor Signaling Pathway Axon Extension Involved In Axon Guidance Negative Chemotaxis Sympathetic Ganglion Development Trigeminal Ganglion Development Semaphorin-plexin Signaling Pathway Sensory Neuron Axon Guidance Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Regulation Of Postsynapse Organization Neural Crest Cell Migration Involved In Autonomic Nervous System Development Facioacoustic Ganglion Development Dorsal Root Ganglion Morphogenesis Cellular Response To Leukemia Inhibitory Factor	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Ovarian Follicle Development Blood Vessel Development Branching Involved In Blood Vessel Morphogenesis Vasculogenesis Response To Hypoxia In Utero Embryonic Development Kidney Development Positive Regulation Of Protein Phosphorylation Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Vasculature Development Lymphangiogenesis Sprouting Angiogenesis Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Neuroblast Proliferation Epithelial Cell Maturation Positive Regulation Of Receptor Internalization Immune System Process Basophil Chemotaxis Positive Regulation Of Leukocyte Migration Heart Morphogenesis Outflow Tract Morphogenesis Coronary Vein Morphogenesis Regulation Of Transcription By RNA Polymerase II Apoptotic Process Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Nervous System Development Neuroblast Proliferation Mesoderm Development Lactation Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Nitric Oxide Mediated Signal Transduction Cell Migration Negative Regulation Of Cell-cell Adhesion Cell Differentiation Monocyte Differentiation Macrophage Differentiation Lung Development Positive Regulation Of Cell Migration Epithelial Cell Differentiation Post-embryonic Camera-type Eye Development Retinal Ganglion Cell Axon Guidance Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein Autophosphorylation Tube Formation Endothelial Cell Chemotaxis Cellular Response To Vascular Endothelial Growth Factor Stimulus Lymph Vessel Morphogenesis Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway VEGF-activated Neuropilin Signaling Pathway Regulation Of Growth Vasodilation Eye Photoreceptor Cell Development Negative Regulation Of Apoptotic Process Positive Regulation Of Vascular Permeability Positive Regulation Of Canonical NF-kappaB Signal Transduction Surfactant Homeostasis Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Endothelial Cell Migration Negative Regulation Of Fat Cell Differentiation Regulation Of Endothelial Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription By RNA Polymerase II Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Maturation Blood Vessel Morphogenesis Camera-type Eye Morphogenesis Positive Regulation Of Axon Extension Involved In Axon Guidance Artery Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Positive Chemotaxis Induction Of Positive Chemotaxis Positive Regulation Of Cell Division Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cardiac Muscle Cell Development Primitive Erythrocyte Differentiation Bone Trabecula Formation Lung Vasculature Development Mammary Gland Alveolus Development Positive Regulation Of Mast Cell Chemotaxis Cardiac Vascular Smooth Muscle Cell Development Coronary Artery Morphogenesis Vascular Wound Healing Bone Trabecula Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Hypoxia Dopaminergic Neuron Differentiation Commissural Neuron Axon Guidance Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Motor Neuron Migration Cellular Stress Response To Acid Chemical Cell-cell Adhesion Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Trophoblast Cell Migration Positive Regulation Of Lymphangiogenesis Regulation Of Hematopoietic Progenitor Cell Differentiation Negative Regulation Of MiRNA Transcription Positive Regulation Of Protein Localization To Early Endosome Negative Regulation Of Establishment Of Endothelial Barrier Negative Regulation Of Adherens Junction Organization Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Epithelial Tube Formation Positive Regulation Of Blood Vessel Branching Negative Regulation Of Blood-brain Barrier Permeability Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Endothelial Cell Chemotaxis
Pathways		Neurophilin interactions with VEGF and VEGFR NrCAM interactions	Platelet degranulation Regulation of gene expression by Hypoxia-inducible Factor Signaling by VEGF VEGF ligand-receptor interactions VEGF binds to VEGFR leading to receptor dimerization Interleukin-4 and Interleukin-13 signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Drugs		ATYR1923	Bevacizumab Minocycline Gliclazide Carvedilol Ranibizumab Pidolic acid Pegaptanib Vandetanib ABT-510 Veglin Denibulin SNS-032 Bevasiranib Dalteparin Aflibercept Chondroitin sulfate Foreskin keratinocyte (neonatal) Vanucizumab Brolucizumab Faricimab
Diseases			Gastric cancer
GWAS		Blood protein levels ( 30072576) Craniofacial microsomia ( 26853712) Daytime nap ( 33568662) Diisocyanate-induced asthma ( 25918132) Neuropathy x type 2 diabetes interaction ( 32541925)	A body shape index ( 34021172) Adiponectin levels ( 22479202) Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 21665990 23455636) Alanine aminotransferase levels ( 33547301 34315874) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301 34315874) Body fat percentage and HDL-C (pairwise) ( 33619380) Body fat percentage and triglycerides (pairwise) ( 33619380) Body mass index ( 25673413) Body mass index and coronary artery disease (pairwise) ( 33619380) Body mass index and HDL-C (pairwise) ( 33619380) Body mass index and triglycerides (pairwise) ( 33619380) Chronic kidney disease ( 20383146) Coronary artery disease ( 29212778 33020668) Coronary heart disease ( 22319020) Creatinine levels ( 29124443 29403010 31015462) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Diastolic blood pressure ( 30224653) Early age-related macular degeneration ( 32843070) Estimated glomerular filtration rate ( 29124443 30604766 31015462) Fasting glucose change (short-term) ( 31263163) Fasting insulin ( 34059833) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate (creatinine) ( 26831199 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899 30698716 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Heel bone mineral density ( 30598549) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High density lipoprotein cholesterol levels ( 29403010 33339817) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Hyperthyroidism ( 30367059) Hyperuricemia ( 29124443) Hypothyroidism ( 27182965) Immature fraction of reticulocytes ( 32888494) Inflammatory biomarkers (multivariate analysis) ( 33110245) Interleukin-10 levels ( 27989323) Interleukin-12p70 levels ( 27989323) Interleukin-13 levels ( 27989323) Interleukin-7 levels ( 27989323) Iron status biomarkers (ferritin levels) ( 33536631) Kidney volume ( 34128465) Liver enzyme levels (alanine transaminase) ( 33972514) Medication use (calcium channel blockers) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 31589552) Myeloid white cell count ( 27863252) Myocardial infarction ( 33532862) Plasma thyroid-stimulating hormone levels ( 28333968) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Prostate-specific antigen levels ( 28139693) Red blood cell count ( 27863252 32888494) Refractive error ( 32231278) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Serum uric acid levels ( 29124443 30993211) Sexual dimorphism in anthropometric traits ( 23754948) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 25743335 32769997) Triglyceride levels ( 28334899 29403010 30698716 32203549 33339817) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglycerides ( 24097068 25961943) Type 2 diabetes ( 18372903 24509480 29358691 30054458 30297969) Urate levels ( 23263486 31578528 31985003) Urinary albumin-to-creatinine ratio ( 31630189) Vascular endothelial growth factor levels ( 26910538 27989323 31217265) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in inactive individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500 34021172) Waist-hip index ( 34021172) Waist-hip ratio ( 20935629 25673412) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 26785701 28448500) White blood cell count ( 27863252)
Interacting Genes		11 interacting genes: FLT1 L1CAM NRP1 PGF PLXNA1 PLXNB1 SEMA3B SEMA3C SEMA3F SEMA4F VEGFA	37 interacting genes: ADAMTS1 AKT1 CCN2 CFTR CRYAB ELAVL1 EPHB2 FLT1 FN1 GJB1 GPC1 HIF1A HNRNPD IGFBP7 KDR LYVE1 MDM2 NRP1 NRP2 PGF PRRG4 SEMA3F SLC16A2 SLC35H1 SP1 SP3 SPARC TFAP2A TMEM237 TNXB U2AF1 UBIAD1 VEGFB VPS35 VTN YBX1 YBX3
Entrez ID		8828	7422
HPRD ID		03643	01889
Ensembl ID		ENSG00000118257	ENSG00000112715
Uniprot IDs		O60462	A0A0Y0IMM4 A2A2V4 P15692
PDB IDs		2QQJ 2QQK 2QQL 2QQO 4QDQ 4QDR 4QDS 5DN2 5DQ0 6GH8 6TDB 6TJT 7M22 7T4S 8IVW 8IVX	1BJ1 1CZ8 1FLT 1KAT 1KMX 1MJV 1MKG 1MKK 1QTY 1TZH 1TZI 1VGH 1VPF 1VPP 2FJG 2FJH 2QR0 2VGH 2VPF 3BDY 3P9W 3QTK 3S1B 3S1K 3V2A 4DEQ 4GLN 4GLS 4KZN 4QAF 4WPB 4ZFF 5DN2 5FV1 5FV2 5HHC 5HHD 5O4E 5T89 6BFT 6D3O 6T9D 6V7K 6Z13 6Z3F 6ZBR 6ZCD 6ZFL 7KEZ 7KF0 7KF1 7LL8 7LL9 8UWZ 9JU1 9KKU
Enriched GO Terms of Interacting Partners?		Semaphorin-plexin Signaling Pathway Chemotaxis Locomotion Neuron Projection Guidance Neuropilin Binding Semaphorin Receptor Binding Cell Migration Regulation Of Cell Migration Regulation Of Cell Motility Cell Motility Regulation Of Locomotion Axon Guidance Neuron Projection Development Neural Crest Cell Migration Regulation Of Axonogenesis Mesenchymal Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Vascular Endothelial Growth Factor Signaling Pathway Cell Projection Organization Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Regulation Of Axon Extension Chemorepellent Activity Cell Surface Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Sprouting Angiogenesis Plasma Membrane Bounded Cell Projection Organization Negative Chemotaxis Ameboidal-type Cell Migration Regulation Of Neurogenesis Semaphorin Receptor Activity Semaphorin Receptor Complex Regulation Of Neuron Projection Development Regulation Of Nervous System Development Regulation Of Axon Extension Involved In Axon Guidance Positive Regulation Of Axonogenesis Regulation Of Anatomical Structure Morphogenesis Retinal Ganglion Cell Axon Guidance VEGF-activated Neuropilin Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of Developmental Growth Negative Regulation Of Axon Extension Ventral Trunk Neural Crest Cell Migration Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Positive Regulation Of Axon Extension Vascular Endothelial Growth Factor Receptor Binding Sympathetic Neuron Projection Guidance Neuropilin Signaling Pathway	Positive Regulation Of Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cell Migration Regulation Of Cell Motility Vascular Endothelial Growth Factor Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Regulation Of Endothelial Cell Proliferation Angiogenesis Regulation Of Developmental Process Heparin Binding Regulation Of Cell Population Proliferation Neural Crest Cell Migration Involved In Autonomic Nervous System Development Positive Regulation Of Cell Population Proliferation Positive Regulation Of Developmental Process Vascular Endothelial Growth Factor Receptor Activity Positive Regulation Of Endothelial Cell Proliferation Animal Organ Development Positive Regulation Of Endothelial Cell Migration Ventral Trunk Neural Crest Cell Migration Vascular Endothelial Growth Factor Receptor Signaling Pathway Extracellular Region Developmental Process Sympathetic Neuron Projection Guidance Growth Factor Binding Negative Regulation Of Gene Expression Anatomical Structure Arrangement Regulation Of Epithelial Cell Proliferation Trunk Neural Crest Cell Migration Regulation Of Multicellular Organismal Process Neural Crest Cell Migration Regulation Of Multicellular Organismal Development Mesenchymal Cell Migration Regulation Of Anatomical Structure Morphogenesis Trigeminal Nerve Structural Organization Sympathetic Neuron Projection Extension Regulation Of Endothelial Cell Migration Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Blood Vessel Endothelial Cell Migration Cell Migration Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process Branchiomotor Neuron Axon Guidance Negative Regulation Of Macromolecule Metabolic Process Ameboidal-type Cell Migration Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Angiogenesis Cellular Response To Vascular Endothelial Growth Factor Stimulus
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