FGF18 and FGFR3

Number of citations of the paper that reports this interaction (PMID 10751172)
45

Data Source:
HPRD (in vitro)

		FGF18	FGFR3
Gene Name		fibroblast growth factor 18	fibroblast growth factor receptor 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleolus	Extracellular Region Nucleus Lysosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cytoplasmic Side Of Plasma Membrane Cell Surface Transport Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	Type 1 Fibroblast Growth Factor Receptor Binding Type 2 Fibroblast Growth Factor Receptor Binding Growth Factor Activity	Protein Tyrosine Kinase Activity Fibroblast Growth Factor-activated Receptor Activity Protein Binding ATP Binding Fibroblast Growth Factor Binding
	Biological Process	Angiogenesis Regulation Of Endothelial Cell Proliferation Intramembranous Ossification Endochondral Ossification Chondrocyte Development Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Signaling Nervous System Development Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Anatomical Structure Morphogenesis Lung Development Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Fc-epsilon Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Sprouting Angiogenesis Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor	Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Skeletal System Development Positive Regulation Of Endothelial Cell Proliferation Endochondral Ossification Morphogenesis Of An Epithelium Chondrocyte Differentiation Lens Morphogenesis In Camera-type Eye Endochondral Bone Growth Epidermal Growth Factor Receptor Signaling Pathway JAK-STAT Cascade Cell-cell Signaling Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Peptidyl-tyrosine Phosphorylation Substantia Nigra Development Central Nervous System Myelination Bone Mineralization Forebrain Development Positive Regulation Of Protein Ubiquitination Somatic Stem Cell Maintenance Chondrocyte Proliferation Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of Cell Differentiation Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of Smoothened Signaling Pathway Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Digestive Tract Morphogenesis Negative Regulation Of Developmental Growth Response To Axon Injury Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Epithelial Cell Proliferation Inner Ear Receptor Cell Differentiation Bone Morphogenesis Axonogenesis Involved In Innervation Alveolar Secondary Septum Development Lens Fiber Cell Development Positive Regulation Of ERK1 And ERK2 Cascade Bone Maturation Epithelial Cell Fate Commitment Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Cochlea Development Positive Regulation Of Canonical Wnt Signaling Pathway Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway
Pathways		Signaling by the B Cell Receptor (BCR) Phospholipase C-mediated cascade Signaling by FGFR in disease SHC-mediated cascade Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Signaling by FGFR2 mutants DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade PI3K Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer Activated point mutants of FGFR2 PI3K events in ERBB4 signaling Signaling by ERBB2 FGFR4 ligand binding and activation Signaling by EGFR Signaling by FGFR3 mutants Downstream signal transduction Signaling by activated point mutants of FGFR3 Fc epsilon receptor (FCERI) signaling Signaling by FGFR mutants Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R PI3K events in ERBB2 signaling Downstream signaling of activated FGFR FGFR3b ligand binding and activation FGFR3c ligand binding and activation FGFR2c ligand binding and activation FGFR ligand binding and activation Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane FGFR3 ligand binding and activation Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR FGFR2 ligand binding and activation FRS2-mediated cascade IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade	Signaling by FGFR in disease Signaling by FGFR3 mutants Signaling by activated point mutants of FGFR3 Signaling by FGFR mutants t(4;14) translocations of FGFR3
Drugs
Diseases
GWAS			Bladder cancer ( 20972438) Urinary bladder cancer ( 20348956)
Protein-Protein Interactions		5 interactors: FGFR1 FGFR2 FGFR3 FGFR4 LYAR	38 interactors: ARAP1 ATF3 BORA C6orf47 CCDC17 CHGB CTSK EPHA4 FGF1 FGF17 FGF18 FGF2 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 GPSM3 GRB2 GTF3C1 HBZ HNRNPL KIAA1377 KRT8 NDUFS6 POLA2 PTK2B RADIL RNF130 RPL8 SH2B1 SLC25A6 SMG7 STAT1 STAT3
Entrez ID		8817	2261
HPRD ID		04766	00624
Ensembl ID		ENSG00000156427	ENSG00000068078
Uniprot IDs		O76093	P22607 Q0IJ44
PDB IDs			1RY7 4K33
Enriched GO Terms of Interacting Partners?		Phosphatidylinositol-mediated Signaling Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Lung Development Respiratory Tube Development Peptidyl-tyrosine Phosphorylation Fc Receptor Signaling Pathway Alveolar Secondary Septum Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Respiratory System Development Cell Fate Commitment Response To Insulin Cellular Response To Peptide Hormone Stimulus Lung Alveolus Development Cellular Response To Peptide Ventricular Zone Neuroblast Division Immune Response-regulating Cell Surface Receptor Signaling Pathway Orbitofrontal Cortex Development Positive Regulation Of Phospholipase Activity Positive Regulation Of MAPK Cascade Response To Peptide Hormone Immune Response-regulating Signaling Pathway Cellular Response To Organonitrogen Compound Midbrain Development Regulation Of Phospholipase Activity Response To Peptide Positive Regulation Of Lipase Activity Forebrain Ventricular Zone Progenitor Cell Division Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Cellular Response To Hormone Stimulus Response To Growth Factor Regulation Of MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Tube Development Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Lung Saccule Development Positive Regulation Of Cell Proliferation Response To Organonitrogen Compound	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Phosphatidylinositol-mediated Signaling Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Response To Insulin Fc-epsilon Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Peptide Hormone Cellular Response To Organonitrogen Compound Fc Receptor Signaling Pathway Response To Peptide Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Hormone Stimulus Immune Response-regulating Signaling Pathway Positive Regulation Of Cell Division Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Response To Organonitrogen Compound Regulation Of Immune Response Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cell Division Response To Hormone Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of Cell Proliferation Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Immune System Process Regulation Of Cell Proliferation Response To Organic Substance Cell-cell Signaling Response To Stress Anatomical Structure Morphogenesis Cell Differentiation Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Cell Surface Receptor Signaling Pathway Anatomical Structure Development Regulation Of Epithelial Cell Migration
Tagcloud ?		abrogated abundance antiapoptotic barely bbc3 bovine cessation coculture collectively cyp19a1 detectable encoding estradiol faslg favored fgf10 fgf2 fibroblast follicle follicles gadd45b gonadotropic granulosa mdm2 mitotic proapoptotic reversed withdrawing	accrue alterations amplified approved braf carry cdkn2a copy cscc csccs cutaneous deleted drivers fda genomic genomically guide inferior metastasize metastatic neck notch1 oncogenic pik3ca recurrently rtk sccs squamous varying
Tagcloud (Difference) ?		abrogated abundance antiapoptotic barely bbc3 bovine cessation coculture collectively cyp19a1 detectable encoding estradiol faslg favored fgf10 fgf2 fibroblast follicle follicles gadd45b gonadotropic granulosa mdm2 mitotic proapoptotic reversed withdrawing	accrue alterations amplified approved braf carry cdkn2a copy cscc csccs cutaneous deleted drivers fda genomic genomically guide inferior metastasize metastatic neck notch1 oncogenic pik3ca recurrently rtk sccs squamous varying
Tagcloud (Intersection) ?