FGF18 and FGFR4

Number of citations of the paper that reports this interaction (PMID 10751172)
45

Data Source:
HPRD (in vitro)

		FGF18	FGFR4
Gene Name		fibroblast growth factor 18	fibroblast growth factor receptor 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleolus	Extracellular Region Nucleoplasm Cytoplasm Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Transport Vesicle
	Molecular Function	Type 1 Fibroblast Growth Factor Receptor Binding Type 2 Fibroblast Growth Factor Receptor Binding Growth Factor Activity	Protein Tyrosine Kinase Activity Fibroblast Growth Factor-activated Receptor Activity Protein Binding ATP Binding Heparin Binding Fibroblast Growth Factor Binding
	Biological Process	Angiogenesis Regulation Of Endothelial Cell Proliferation Intramembranous Ossification Endochondral Ossification Chondrocyte Development Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Signaling Nervous System Development Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Anatomical Structure Morphogenesis Lung Development Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Fc-epsilon Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Sprouting Angiogenesis Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor	Organ Induction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Gene Expression Regulation Of Extracellular Matrix Disassembly Cell Migration Peptidyl-tyrosine Phosphorylation Regulation Of Lipid Metabolic Process Fc-epsilon Receptor Signaling Pathway Glucose Homeostasis Innate Immune Response Positive Regulation Of Proteolysis Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Metalloenzyme Activity Phosphate Ion Homeostasis Alveolar Secondary Septum Development Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Bile Acid Biosynthetic Process Response To Bile Acid Regulation Of Cholesterol Homeostasis Positive Regulation Of DNA Biosynthetic Process
Pathways		Signaling by the B Cell Receptor (BCR) Phospholipase C-mediated cascade Signaling by FGFR in disease SHC-mediated cascade Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Signaling by FGFR2 mutants DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade PI3K Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer Activated point mutants of FGFR2 PI3K events in ERBB4 signaling Signaling by ERBB2 FGFR4 ligand binding and activation Signaling by EGFR Signaling by FGFR3 mutants Downstream signal transduction Signaling by activated point mutants of FGFR3 Fc epsilon receptor (FCERI) signaling Signaling by FGFR mutants Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R PI3K events in ERBB2 signaling Downstream signaling of activated FGFR FGFR3b ligand binding and activation FGFR3c ligand binding and activation FGFR2c ligand binding and activation FGFR ligand binding and activation Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane FGFR3 ligand binding and activation Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR FGFR2 ligand binding and activation FRS2-mediated cascade IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade	Signaling by the B Cell Receptor (BCR) Phospholipase C-mediated cascade Signaling by FGFR in disease SHC-mediated cascade Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation Signaling by FGFR4 mutants PI-3K cascade PI3K Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 FGFR4 ligand binding and activation Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by FGFR mutants Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R PI3K events in ERBB2 signaling Downstream signaling of activated FGFR FGFR ligand binding and activation Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer betaKlotho-mediated ligand binding Signaling by FGFR Klotho-mediated ligand binding FRS2-mediated cascade IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade
Drugs			Palifermin Ponatinib
Diseases
GWAS			Activated partial thromboplastin time ( 22703881)
Protein-Protein Interactions		5 interactors: FGFR1 FGFR2 FGFR3 FGFR4 LYAR	17 interactors: CDH2 EPHA4 FGF1 FGF17 FGF18 FGF19 FGF2 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 PLCG1 STAT1 STAT3
Entrez ID		8817	2264
HPRD ID		04766	00625
Ensembl ID		ENSG00000156427	ENSG00000160867
Uniprot IDs		O76093	G3JVM2 J3KPQ0 P22455 Q96KE5
PDB IDs			1QCT
Enriched GO Terms of Interacting Partners?		Phosphatidylinositol-mediated Signaling Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Lung Development Respiratory Tube Development Peptidyl-tyrosine Phosphorylation Fc Receptor Signaling Pathway Alveolar Secondary Septum Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Respiratory System Development Cell Fate Commitment Response To Insulin Cellular Response To Peptide Hormone Stimulus Lung Alveolus Development Cellular Response To Peptide Ventricular Zone Neuroblast Division Immune Response-regulating Cell Surface Receptor Signaling Pathway Orbitofrontal Cortex Development Positive Regulation Of Phospholipase Activity Positive Regulation Of MAPK Cascade Response To Peptide Hormone Immune Response-regulating Signaling Pathway Cellular Response To Organonitrogen Compound Midbrain Development Regulation Of Phospholipase Activity Response To Peptide Positive Regulation Of Lipase Activity Forebrain Ventricular Zone Progenitor Cell Division Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Cellular Response To Hormone Stimulus Response To Growth Factor Regulation Of MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Tube Development Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Lung Saccule Development Positive Regulation Of Cell Proliferation Response To Organonitrogen Compound	Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cellular Response To Peptide Hormone Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Insulin Stimulus Cellular Response To Peptide Phosphatidylinositol-mediated Signaling Fc-epsilon Receptor Signaling Pathway Insulin Receptor Signaling Pathway Fc Receptor Signaling Pathway Response To Insulin Enzyme Linked Receptor Protein Signaling Pathway Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Cellular Response To Hormone Stimulus Response To Growth Factor Immune Response-regulating Signaling Pathway Innate Immune Response Response To Organonitrogen Compound Regulation Of Immune Response Response To Hormone Defense Response Positive Regulation Of Cell Division Positive Regulation Of Cell Proliferation Immune Response Regulation Of Immune System Process Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Cell Proliferation Regulation Of Cell Division Cell Surface Receptor Signaling Pathway System Development Response To Organic Substance Immune System Process Multicellular Organismal Development Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Anatomical Structure Development Positive Regulation Of MAPK Cascade Developmental Process Cell Differentiation Response To Stress Positive Regulation Of Phosphorylation
Tagcloud ?		abrogated abundance antiapoptotic barely bbc3 bovine cessation coculture collectively cyp19a1 detectable encoding estradiol faslg favored fgf10 fgf2 fibroblast follicle follicles gadd45b gonadotropic granulosa mdm2 mitotic proapoptotic reversed withdrawing	5q35 boundary british canx centromeric conspicuously d5s2006 d5s2073 d5s408 dominantly genomewide hampered haplotypes hk3 hnrph1 lymphatic lymphedema milroy mim multipoint pcl penetrance positionally recombinants scorable segregated telomeric vicinity wiaf
Tagcloud (Difference) ?		abrogated abundance antiapoptotic barely bbc3 bovine cessation coculture collectively cyp19a1 detectable encoding estradiol faslg favored fgf10 fgf2 fibroblast follicle follicles gadd45b gonadotropic granulosa mdm2 mitotic proapoptotic reversed withdrawing	5q35 boundary british canx centromeric conspicuously d5s2006 d5s2073 d5s408 dominantly genomewide hampered haplotypes hk3 hnrph1 lymphatic lymphedema milroy mim multipoint pcl penetrance positionally recombinants scorable segregated telomeric vicinity wiaf
Tagcloud (Intersection) ?