TRIM24 and CBX1

Number of citations of the paper that reports this interaction (PubMedID 10562550)
0

Data Source:
HPRD (in vitro)

		TRIM24	CBX1
Description		tripartite motif containing 24	chromobox 1
Image
GO Annotations	Cellular Component	Chromatin Euchromatin Male Germ Cell Nucleus Nucleus Nucleoplasm Perichromatin Fibrils Cytoplasm Mitochondrion Cytosol Nuclear Lumen	Chromosome, Centromeric Region Chromosome, Telomeric Region Chromatin Heterochromatin Female Pronucleus Male Pronucleus Nucleus Nucleoplasm Pericentric Heterochromatin Spindle Chromocenter Nuclear Body Site Of DNA Damage
	Molecular Function	P53 Binding DNA Binding Chromatin Binding Transcription Coactivator Activity Protein Kinase Activity Ubiquitin-protein Transferase Activity Signaling Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Nuclear Receptor Binding Estrogen Response Element Binding Sequence-specific DNA Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Histone H3K23ac Reader Activity	Chromatin Binding Protein Binding Enzyme Binding Identical Protein Binding Histone Methyltransferase Binding
	Biological Process	Chromatin Organization Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Protein Ubiquitination Protein Catabolic Process Regulation Of Protein Stability Regulation Of Apoptotic Process Response To Peptide Hormone Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Calcium Ion Homeostasis Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Estrogen Stimulus Regulation Of Signal Transduction By P53 Class Mediator	DNA Damage Response Heterochromatin Formation Negative Regulation Of DNA-templated Transcription
Pathways		Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Signaling by BRAF and RAF1 fusions	HCMV Early Events
Drugs
Diseases
GWAS		Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Quantitative traits ( 19197348)	Aspartate aminotransferase levels ( 33547301) Body mass index ( 20935630 26426971) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Generalized epilepsy ( 22949513)
Interacting Genes		54 interacting genes: AKT1 AR ATF4 BRCA1 BRD7 CBX1 CBX3 CBX5 CREBBP ESR1 ESR2 FOSL1 GTF2E1 H3C1 H3C10 H3C11 H3C12 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 HNF4A HSPA1A HSPB1 MTNR1B NFE2L2 NR2F2 NR3C1 NR3C2 PGR PML RARA RNF141 RNF181 RXRA STAT6 SUMO1 TAF11 TAF1B TAF1C TAF7 THRA TRAF3 TRIM28 TRIM33 TRIM8 UBE2D1 UBE2I UBE2U VDR ZNF10	34 interacting genes: ABI3BP ARL5A ATXN7L2 BAHD1 BARD1 BRCA1 CBX3 CBX5 CHAF1A DNMT1 DNMT3A DNMT3B EMSY H1-4 H3-4 H3C1 H3C3 HECW2 HSPB1 KLF11 LNX1 LRIF1 NR2F6 PCNA PIM1 RPL12 SP100 SUV39H1 TRIM24 TRIM28 UCHL1 VHL VTN ZNF280C
Entrez ID		8805	10951
HPRD ID		04556	05149
Ensembl ID		ENSG00000122779	ENSG00000108468
Uniprot IDs		O15164	P83916 Q6IBN6
PDB IDs		2YYN 3O33 3O34 3O35 3O36 3O37 4YAB 4YAD 4YAT 4YAX 4YBM 4YBS 4YBT 4YC9 4ZQL 5H1T 5H1U 5H1V 7B9X	2FMM 3F2U 3Q6S 5T1G 6D07 6D08
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nuclear Receptor Activity Protein-DNA Complex Assembly Regulation Of Gene Expression Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process DNA Binding Gene Expression Protein-containing Complex Epigenetic Regulation Of Gene Expression Intracellular Receptor Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Regulation Of Macromolecule Metabolic Process Structural Constituent Of Chromatin Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Organization Chromatin Remodeling Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Hormone-mediated Signaling Pathway Nucleosome Assembly Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Macromolecule Metabolic Process Regulation Of Metabolic Process Nucleosome Protein Heterodimerization Activity Telomere Organization Estrogen Response Element Binding Nucleosome Organization Nuclear Steroid Receptor Activity Regulation Of RNA Metabolic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Chromatin Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific DNA Binding RNA Polymerase II Transcription Regulator Complex MRNA Transcription Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Transcription By RNA Polymerase II MRNA Transcription By RNA Polymerase II	Chromatin Organization Heterochromatin Chromatin Remodeling Epigenetic Regulation Of Gene Expression Heterochromatin Formation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA (cytosine-5-)-methyltransferase Activity Nucleoplasm Chromatin Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Euchromatin Chromo Shadow Domain Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Epigenetic Programming Of Gene Expression Negative Regulation Of Biosynthetic Process Ubiquitin-protein Transferase Activity Chromosome Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Chromosome, Telomeric Region Regulation Of Primary Metabolic Process DNA Damage Response Nucleosome Assembly Histone H2AK127 Ubiquitin Ligase Activity Nucleus Histone H2AK129 Ubiquitin Ligase Activity Regulation Of Macromolecule Metabolic Process BRCA1-BARD1 Complex Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Regulation Of Metabolic Process Nucleosome Organization DNA Binding Cellular Response To Stress DNA-methyltransferase Activity BRCA1-B Complex Cellular Response To Bisphenol A Structural Constituent Of Chromatin Pericentric Heterochromatin Post-translational Protein Modification Protein-DNA Complex Assembly
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