TRIM24 and RNF181

Number of citations of the paper that reports this interaction (PubMedID 22493164)
44

Data Source:
BioGRID (two hybrid)

		TRIM24	RNF181
Description		tripartite motif containing 24	ring finger protein 181
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Euchromatin Male Germ Cell Nucleus Nucleus Nucleoplasm Perichromatin Fibrils Cytoplasm Mitochondrion Cytosol Nuclear Lumen	Cytoplasm
	Molecular Function	P53 Binding DNA Binding Chromatin Binding Transcription Coactivator Activity Protein Kinase Activity Ubiquitin-protein Transferase Activity Signaling Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Nuclear Receptor Binding Estrogen Response Element Binding Sequence-specific DNA Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Histone H3K23ac Reader Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Chromatin Organization Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Protein Ubiquitination Protein Catabolic Process Regulation Of Protein Stability Regulation Of Apoptotic Process Response To Peptide Hormone Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Calcium Ion Homeostasis Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Estrogen Stimulus Regulation Of Signal Transduction By P53 Class Mediator	Protein Ubiquitination Protein Autoubiquitination
Pathways		Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Signaling by BRAF and RAF1 fusions	E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Quantitative traits ( 19197348)	Prostate cancer ( 21743467)
Interacting Genes		54 interacting genes: AKT1 AR ATF4 BRCA1 BRD7 CBX1 CBX3 CBX5 CREBBP ESR1 ESR2 FOSL1 GTF2E1 H3C1 H3C10 H3C11 H3C12 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 HNF4A HSPA1A HSPB1 MTNR1B NFE2L2 NR2F2 NR3C1 NR3C2 PGR PML RARA RNF141 RNF181 RXRA STAT6 SUMO1 TAF11 TAF1B TAF1C TAF7 THRA TRAF3 TRIM28 TRIM33 TRIM8 UBE2D1 UBE2I UBE2U VDR ZNF10	32 interacting genes: ALB BCL10 BIRC2 BTG1 CARD11 CLK4 ELL2 FGB HBA1 MCM7 MRPS6 MT1E MT1H NDUFB10 NPY5R PEG10 RBCK1 RPL5 SFMBT2 TRIM24 TRIM8 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2U VPS11 ZMYND10
Entrez ID		8805	51255
HPRD ID		04556	14236
Ensembl ID		ENSG00000122779	ENSG00000168894
Uniprot IDs		O15164	Q9P0P0
PDB IDs		2YYN 3O33 3O34 3O35 3O36 3O37 4YAB 4YAD 4YAT 4YAX 4YBM 4YBS 4YBT 4YC9 4ZQL 5H1T 5H1U 5H1V 7B9X
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nuclear Receptor Activity Protein-DNA Complex Assembly Regulation Of Gene Expression Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process DNA Binding Gene Expression Protein-containing Complex Epigenetic Regulation Of Gene Expression Intracellular Receptor Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Regulation Of Macromolecule Metabolic Process Structural Constituent Of Chromatin Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Organization Chromatin Remodeling Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Hormone-mediated Signaling Pathway Nucleosome Assembly Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Macromolecule Metabolic Process Regulation Of Metabolic Process Nucleosome Protein Heterodimerization Activity Telomere Organization Estrogen Response Element Binding Nucleosome Organization Nuclear Steroid Receptor Activity Regulation Of RNA Metabolic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Chromatin Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific DNA Binding RNA Polymerase II Transcription Regulator Complex MRNA Transcription Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Transcription By RNA Polymerase II MRNA Transcription By RNA Polymerase II	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Post-translational Protein Modification Protein K48-linked Ubiquitination Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Proteolysis Involved In Protein Catabolic Process Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Metabolic Process Protein Monoubiquitination Positive Regulation Of Protein Polyubiquitination Proteolysis Transferase Activity Protein K63-linked Ubiquitination Positive Regulation Of NF-kappaB Transcription Factor Activity Catabolic Process Regulation Of Protein Polyubiquitination Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein Ubiquitination CBM Complex Positive Regulation Of Protein Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of DNA-binding Transcription Factor Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Post-translational Protein Modification Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Post-translational Protein Modification Protein Catabolic Process Regulation Of Intracellular Signal Transduction ATP Binding Transcription Coactivator Activity Canonical NF-kappaB Signal Transduction Nucleotide Binding Macromolecule Metabolic Process Proteasomal Protein Catabolic Process TORC1 Signaling Detoxification Of Copper Ion Nucleus Regulation Of Protein K63-linked Ubiquitination CARD Domain Binding Regulation Of DNA-binding Transcription Factor Activity Protein-containing Complex TOR Signaling Regulation Of Signal Transduction
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