TRIM24 and NFE2L2

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		TRIM24	NFE2L2
Description		tripartite motif containing 24	NFE2 like bZIP transcription factor 2
Image
GO Annotations	Cellular Component	Chromatin Euchromatin Male Germ Cell Nucleus Nucleus Nucleoplasm Perichromatin Fibrils Cytoplasm Mitochondrion Cytosol Nuclear Lumen	Chromatin Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol Plasma Membrane Mediator Complex Protein-DNA Complex Ciliary Basal Body RNA Polymerase II Transcription Regulator Complex
	Molecular Function	P53 Binding DNA Binding Chromatin Binding Transcription Coactivator Activity Protein Kinase Activity Ubiquitin-protein Transferase Activity Signaling Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Nuclear Receptor Binding Estrogen Response Element Binding Sequence-specific DNA Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Histone H3K23ac Reader Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Molecular Condensate Scaffold Activity
	Biological Process	Chromatin Organization Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Protein Ubiquitination Protein Catabolic Process Regulation Of Protein Stability Regulation Of Apoptotic Process Response To Peptide Hormone Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Calcium Ion Homeostasis Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Estrogen Stimulus Regulation Of Signal Transduction By P53 Class Mediator	Response To Ischemia Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Inflammatory Response Response To Oxidative Stress Response To Xenobiotic Stimulus Gene Expression Proteasomal Ubiquitin-independent Protein Catabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Protein Ubiquitination Positive Regulation Of Blood Coagulation Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Oxidative Stress Response To Endoplasmic Reticulum Stress PERK-mediated Unfolded Protein Response Cellular Response To Glucose Starvation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Innate Immune Response Cell Redox Homeostasis Positive Regulation Of Angiogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Aflatoxin Catabolic Process Positive Regulation Of D-glucose Import Cellular Response To Methionine Response To Caloric Restriction Cellular Response To Hydrogen Peroxide Cellular Response To Copper Ion Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To Xenobiotic Stimulus Cellular Response To Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Reactive Oxygen Species Metabolic Process Negative Regulation Of Ferroptosis Integrated Stress Response Signaling Negative Regulation Of Cellular Response To Hypoxia Regulation Of Cellular Response To Oxidative Stress Negative Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Glutathione Biosynthetic Process Positive Regulation Of ERAD Pathway Cellular Response To Angiotensin Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Removal Of Superoxide Radicals Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Signaling by BRAF and RAF1 fusions	Neddylation Potential therapeutics for SARS Regulation of HMOX1 expression and activity Heme signaling KEAP1-NFE2L2 pathway KEAP1-NFE2L2 pathway Nuclear events mediated by NFE2L2 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 NFE2L2 regulating TCA cycle genes NFE2L2 regulating inflammation associated genes NFE2L2 regulating anti-oxidant/detoxification enzymes NFE2L2 regulates pentose phosphate pathway genes NFE2L2 regulating tumorigenic genes NFE2L2 regulating MDR associated enzymes NFE2L2 regulating ER-stress associated genes Regulation of NFE2L2 gene expression Regulation of NFE2L2 gene expression Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS		Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Quantitative traits ( 19197348)	A body shape index ( 34021172) Estimated glomerular filtration rate ( 30604766 31152163 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) HDL cholesterol levels ( 32203549) Refractive error ( 32231278)
Interacting Genes		54 interacting genes: AKT1 AR ATF4 BRCA1 BRD7 CBX1 CBX3 CBX5 CREBBP ESR1 ESR2 FOSL1 GTF2E1 H3C1 H3C10 H3C11 H3C12 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 HNF4A HSPA1A HSPB1 MTNR1B NFE2L2 NR2F2 NR3C1 NR3C2 PGR PML RARA RNF141 RNF181 RXRA STAT6 SUMO1 TAF11 TAF1B TAF1C TAF7 THRA TRAF3 TRIM28 TRIM33 TRIM8 UBE2D1 UBE2I UBE2U VDR ZNF10	85 interacting genes: APEX1 ARFIP2 ARPC2 ATF3 ATF4 ATM ATR BPTF BRPF1 BRPF3 BTRC CASP1 CASP3 CDH1 CEBPG CERS2 CFAP299 CHD6 CLIC6 COPS7A CREB3 CREBBP CREBL2 CREBZF DDIT3 EIF2AK3 EIF3J ELF1 ELF3 ELF4 ELF5 ELK1 ETV1 ETV4 ETV6 FBXW11 FOSB FOSL2 GSK3B HNRNPR IRF2 JUN JUND KDM1A KEAP1 KPNA2 KPNA3 KPNA4 LEF1 MAFF MAFG MAFK MAP2K6 MAPK7 MAPK8 NCOR2 NFAT5 NFE2 NFE2L3 PAQR4 PMF1 PPARG PRKCA PRKCD RBMX REL RELA SMAD1 SP140 SPIC STAT3 SUMO1 SUMO2 TADA2A TBP TEF TIGAR TNNT1 TRIM24 TRIM41 USP11 USP8 WAC ZBTB24 ZNF396
Entrez ID		8805	4780
HPRD ID		04556	02732
Ensembl ID		ENSG00000122779	ENSG00000116044
Uniprot IDs		O15164	A0A8V8TN14 A0A8V8TPA8 Q16236
PDB IDs		2YYN 3O33 3O34 3O35 3O36 3O37 4YAB 4YAD 4YAT 4YAX 4YBM 4YBS 4YBT 4YC9 4ZQL 5H1T 5H1U 5H1V 7B9X	2FLU 2LZ1 3ZGC 4IFL 5WFV 6T7V 7K28 7K29 7K2A 7K2B 7K2C 7K2D 7K2E 7K2K 7O7B 7X5E 7X5F 7X5G 8EJR 8EJS
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nuclear Receptor Activity Protein-DNA Complex Assembly Regulation Of Gene Expression Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process DNA Binding Gene Expression Protein-containing Complex Epigenetic Regulation Of Gene Expression Intracellular Receptor Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Regulation Of Macromolecule Metabolic Process Structural Constituent Of Chromatin Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Organization Chromatin Remodeling Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Hormone-mediated Signaling Pathway Nucleosome Assembly Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Macromolecule Metabolic Process Regulation Of Metabolic Process Nucleosome Protein Heterodimerization Activity Telomere Organization Estrogen Response Element Binding Nucleosome Organization Nuclear Steroid Receptor Activity Regulation Of RNA Metabolic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Chromatin Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific DNA Binding RNA Polymerase II Transcription Regulator Complex MRNA Transcription Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Transcription By RNA Polymerase II MRNA Transcription By RNA Polymerase II	Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Chromatin Nucleus Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleoplasm RNA Polymerase II Transcription Regulator Complex Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Integrated Stress Response Signaling Intracellular Signaling Cassette Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Intracellular Signal Transduction Transcription Cis-regulatory Region Binding Transcription By RNA Polymerase II Cellular Response To Stress Response To Stress Chromatin Binding Transcription Regulator Complex Cellular Response To Chemical Stress
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