TRIM24 and TRIM33

Number of citations of the paper that reports this interaction (PMID 12096914)
26

Data Source:
HPRD (in vivo, in vitro)

		TRIM24	TRIM33
Gene Name		tripartite motif containing 24	tripartite motif containing 33
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Euchromatin Perichromatin Fibrils Cytosol	Nucleus Nucleoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	P53 Binding Chromatin Binding Transcription Coactivator Activity Protein Kinase Activity Ubiquitin-protein Transferase Activity Receptor Binding Protein Binding Zinc Ion Binding Ligase Activity Ligand-dependent Nuclear Receptor Binding Estrogen Response Element Binding Methylated Histone Binding Sequence-specific DNA Binding Lysine-acetylated Histone Binding	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Co-SMAD Binding R-SMAD Binding
	Biological Process	Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Proliferation Protein Ubiquitination Protein Catabolic Process Regulation Of Protein Stability Regulation Of Apoptotic Process Response To Peptide Hormone Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Calcium Ion Homeostasis Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Estrogen Stimulus Regulation Of Signal Transduction By P53 Class Mediator	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Protein Ubiquitination Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Transcription, DNA-templated
Pathways		Signaling by FGFR in disease Signaling by FGFR1 mutants Signaling by FGFR mutants Signaling by FGFR1 fusion mutants	Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity TGFBR1 LBD Mutants in Cancer Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Loss of Function of TGFBR1 in Cancer Generic Transcription Pathway Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Quantitative traits ( 19197348)
Protein-Protein Interactions		47 interactors: AR ATF4 BRCA1 BRD7 CBX1 CBX3 CBX5 ESR1 ESR2 FOSL1 GTF2E1 HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HNF4A HSPA1A NFE2L2 NR2F2 NR3C1 NR3C2 PGR PML PPARG RARA RNF141 RNF181 RXRA STAT6 SUMO1 TAF11 TAF1B TAF1C TAF7 THRA TRIM28 TRIM33 TRIM8 UBE2U VDR ZNF10	5 interactors: HIST1H3A TRIM24 UBE2D3 UBE2E1 UBE2N
Entrez ID		8805	51592
HPRD ID		04556	10423
Ensembl ID		ENSG00000122779	ENSG00000197323
Uniprot IDs		O15164	B3KN30 Q9UPN9
PDB IDs		2YYN 3O33 3O34 3O35 3O36 3O37	3U5M 3U5N 3U5O 3U5P
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Chromatin Silencing At RDNA Regulation Of Nitrogen Compound Metabolic Process DNA-templated Transcription, Initiation Gene Expression Transcription Initiation From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Replication-dependent Nucleosome Assembly Chromatin Silencing Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process DNA Methylation On Cytosine Steroid Hormone Mediated Signaling Pathway Nitrogen Compound Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Gene Silencing Regulation Of Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Transcription From RNA Polymerase II Promoter Hormone-mediated Signaling Pathway DNA Methylation Gene Silencing Regulation Of Gene Expression, Epigenetic Cellular Response To Steroid Hormone Stimulus Transcription, DNA-templated DNA Modification RNA Biosynthetic Process Response To Steroid Hormone Cellular Response To Organic Cyclic Compound Cellular Metabolic Process RNA Metabolic Process Protein-DNA Complex Assembly Nucleosome Assembly Chromatin Assembly Cellular Macromolecule Biosynthetic Process Nucleosome Organization Cellular Response To Lipid Macromolecule Biosynthetic Process Chromatin Assembly Or Disassembly	Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Protein Polyubiquitination Histone Ubiquitination Protein K48-linked Ubiquitination Protein Monoubiquitination Positive Regulation Of Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Ligase Activity Toll-like Receptor 4 Signaling Pathway Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Catabolic Process Cellular Response To Organic Substance Toll-like Receptor Signaling Pathway Chromatin Organization Negative Regulation Of Cellular Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Activation Of Innate Immune Response Cellular Macromolecule Catabolic Process Positive Regulation Of Innate Immune Response Response To Organic Substance Regulation Of Protein Ubiquitination Regulation Of Chromosome Organization Chromosome Organization Regulation Of Histone Ubiquitination DNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Innate Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Vitamin D Receptor Signaling Pathway ISG15-protein Conjugation Cellular Protein Modification Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process DNA Double-strand Break Processing Histone H2B Ubiquitination DNA Replication-dependent Nucleosome Assembly Proteolysis DNA Methylation On Cytosine Histone Modification Regulation Of Metabolic Process
Tagcloud ?		advance aerobic alongside bromodomain doi ectopic glycolysis glycolytic greatly hmec hmecs homeodomain ihmecs immortalized isogenic july mammoplasty nude onc online publication reader reprogramming signature subcutaneous tricarboxylic tripartite tumorigenesis viable	acquire acquires antagonizes axis bmp bonus decapentaplegic demonstration dorsal dpp evolve flies ligase morphogenetic nedd4l newest nonconservation patterning performs replaced smad smad4 tif1 topics uncovering ventral vertebrate vertebrates wholly
Tagcloud (Difference) ?		advance aerobic alongside bromodomain doi ectopic glycolysis glycolytic greatly hmec hmecs homeodomain ihmecs immortalized isogenic july mammoplasty nude onc online publication reader reprogramming signature subcutaneous tricarboxylic tripartite tumorigenesis viable	acquire acquires antagonizes axis bmp bonus decapentaplegic demonstration dorsal dpp evolve flies ligase morphogenetic nedd4l newest nonconservation patterning performs replaced smad smad4 tif1 topics uncovering ventral vertebrate vertebrates wholly
Tagcloud (Intersection) ?