CSRP3 and LDHD

Number of citations of the paper that reports this interaction (PubMedID 12127981)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		CSRP3	LDHD
Description		cysteine and glycine rich protein 3	lactate dehydrogenase D
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Sarcomere Z Disc	Mitochondrion Mitochondrial Inner Membrane
	Molecular Function	Actin Binding Protein Binding Structural Constituent Of Muscle Telethonin Binding Identical Protein Binding Actinin Binding Metal Ion Binding	Catalytic Activity Lactate Dehydrogenase Activity D-lactate Dehydrogenase (cytochrome) Activity Protein Binding D-lactate Dehydrogenase (NAD+) Activity Oxidoreductase Activity Flavin Adenine Dinucleotide Binding FAD Binding
	Biological Process	Regulation Of The Force Of Heart Contraction Cardiac Muscle Hypertrophy Intracellular Calcium Ion Homeostasis Inflammatory Response Heart Development Muscle Organ Development Skeletal Muscle Tissue Development Insulin Receptor Signaling Pathway Cell Differentiation T-tubule Organization Protein Localization To Organelle Detection Of Muscle Stretch Glucose Homeostasis Sarcomere Organization Negative Regulation Of Myoblast Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Muscle Cell Cellular Homeostasis Cardiac Muscle Tissue Development Cardiac Myofibril Assembly Cardiac Muscle Contraction Muscle Tissue Development Establishment Of Protein Localization To Organelle Phospholipase C/protein Kinase C Signal Transduction Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Actin Filament Severing Positive Regulation Of Actin Filament Severing	Lactate Catabolic Process
Pathways			Mitochondrial protein import Mitochondrial protein import Mitochondrial protein degradation
Drugs
Diseases		Hypertrophic cardiomyopathy (HCM)
GWAS		Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Mosquito bite size ( 28199695) Red blood cell count ( 27863252 32888494)	Crohn's disease (time to surgery) ( 23665963) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Pancreatic cancer ( 25086665) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		11 interacting genes: ACTN1 FHL1 HDAC4 LDHD LIMS1 MYF6 MYOD1 MYOG NHLH1 RIN3 SPTB	1 interacting genes: CSRP3
Entrez ID		8048	197257
HPRD ID		07525	06318
Ensembl ID		ENSG00000129170	ENSG00000166816
Uniprot IDs		A0A3B3ISZ2 A2TDB8 P50461	Q86WU2
PDB IDs		2O10 2O13
Enriched GO Terms of Interacting Partners?		Regulation Of Myotube Differentiation Positive Regulation Of Skeletal Muscle Fiber Development Regulation Of Skeletal Muscle Fiber Development Muscle Cell Fate Commitment Positive Regulation Of Striated Muscle Tissue Development Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Skeletal Muscle Tissue Development DNA-binding Transcription Activator Activity Regulation Of Skeletal Muscle Tissue Development Muscle Organ Development Muscle Structure Development Regulation Of Muscle Cell Differentiation Regulation Of Striated Muscle Tissue Development Positive Regulation Of Striated Muscle Cell Differentiation Regulation Of Muscle Organ Development Positive Regulation Of Myoblast Differentiation Protein Dimerization Activity E-box Binding Skeletal Muscle Cell Differentiation Response To Denervation Involved In Regulation Of Muscle Adaptation Skeletal Muscle Tissue Development Response To Muscle Inactivity Cell Differentiation Regulation Of Myoblast Differentiation Positive Regulation Of Muscle Cell Differentiation Response To Inactivity Muscle Cell Development Cellular Developmental Process Striated Muscle Tissue Development Skeletal Muscle Tissue Regeneration Regulation Of Myoblast Fusion Myotube Differentiation Muscle Tissue Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Skeletal Muscle Fiber Development Cell Fate Commitment Myotube Cell Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cellular Response To Estradiol Stimulus Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Sequence-specific Double-stranded DNA Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process Tissue Regeneration Cortical Actin Cytoskeleton Negative Regulation Of Mast Cell Chemotaxis D-lactate Dehydrogenase (cytochrome) Activity	Positive Regulation Of Actin Filament Severing Negative Regulation Of Actin Filament Severing Toll Signaling Pathway Toll-like Receptor 2 Signaling Pathway Detection Of Muscle Stretch Phospholipase C/protein Kinase C Signal Transduction T-tubule Organization Telethonin Binding Interleukin-33-mediated Signaling Pathway Toll-like Receptor 9 Signaling Pathway Interleukin-1-mediated Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Endolysosomal Toll-like Receptor Signaling Pathway Intracellular Signaling Cassette Muscle Cell Cellular Homeostasis Response To Muscle Stretch Regulation Of The Force Of Heart Contraction Cardiac Muscle Hypertrophy Muscle Hypertrophy Cardiac Myofibril Assembly Negative Regulation Of Myoblast Differentiation Actinin Binding Myofibril Assembly Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Cell Surface Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Structural Constituent Of Muscle Cardiac Muscle Contraction Detection Of Mechanical Stimulus Positive Regulation Of Myoblast Differentiation Sarcomere Organization Type I Interferon-mediated Signaling Pathway Toll-like Receptor Signaling Pathway Defense Response Cellular Response To Heat Cell Surface Pattern Recognition Receptor Signaling Pathway Sarcomere JNK Cascade Canonical NF-kappaB Signal Transduction Heat Shock Protein Binding Cardiac Muscle Tissue Development
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