LPP and SHPRH

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		LPP	SHPRH
Description		LIM domain containing preferred translocation partner in lipoma	SNF2 histone linker PHD RING helicase
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Anchoring Junction	Nucleosome Nucleus Nucleoplasm
	Molecular Function	Protein Binding Metal Ion Binding	Nucleotide Binding DNA Binding Helicase Activity Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Zinc Ion Binding Transferase Activity Hydrolase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Cell Adhesion Cell-cell Adhesion	Protein Polyubiquitination DNA Repair Nucleosome Assembly DNA Damage Response Protein Ubiquitination
Pathways			E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Addison's disease ( 33574239) Adult body size ( 32376654) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184 31361310) Allergic sensitization ( 23817571 30013184) Allergy ( 27182965) Alopecia areata ( 25608926) Asthma ( 27182965 30929738 31361310 31619474 31959851 32296059 34103634) Asthma (childhood onset) ( 30929738 31036433) Asthma onset (childhood vs adult) ( 30929738) Autoimmune thyroid disease ( 32581359) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) B cell non-Hodgkin lymphoma ( 23749188) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Basal cell carcinoma ( 27539887 31174203 33549134) Celiac disease ( 18311140 20190752 22057235 30572963) Chronic kidney disease ( 29124443) Chronic lymphocytic leukemia ( 26956414 28165464) Creatinine levels ( 29124443) Crohn's disease ( 28067908) Cutaneous squamous cell carcinoma ( 27424798) CV-A6-associated hand, foot, and mouth disease (severe vs mild) ( 32634583) Early spontaneous preterm birth ( 31477735) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Estimated glomerular filtration rate ( 29124443) Evening vs. morning chronotype (sMEQ score) ( 32579418) Femur bone mineral density x serum urate levels interaction ( 34046847) Follicular lymphoma ( 25279986) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 29891935 33627673) Glucose homeostasis traits ( 25524916) Granulocyte percentage of myeloid white cells ( 27863252) Graves' disease ( 22922229) Gut microbiota relative abundance (unclassified genus belonging to the order Clostridiales) ( 33208821) Hodgkin's lymphoma ( 29196614) IgE levels ( 22075330) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Inflammatory bowel disease ( 28067908) Intraocular pressure ( 29235454 29617998 29785010 31959993) Itch intensity from mosquito bite ( 28199695) Keratinocyte cancer (MTAG) ( 31174203) Mean spheric corpuscular volume ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 32888494) Monocyte percentage of white cells ( 27863252 32888494) Mortality in sepsis ( 27639821) Mosquito bite size ( 28199695) Multiple sclerosis ( 24076602 31604244) Neutrophil percentage of granulocytes ( 27863252) Nodular sclerosis Hodgkin lymphoma ( 29196614) Obesity-related traits ( 23251661) Platelet distribution width ( 32888494) Renal function-related traits (BUN) ( 22797727) Response to platinum-based chemotherapy (cisplatin) ( 21844884) Self-reported allergy ( 23817569) Serum urea levels ( 30808845) Squamous cell carcinoma ( 31174203) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966) Thyroid stimulating hormone levels ( 32769997) Triglyceride levels ( 32203549) Type 2 diabetes ( 24509480 25760438 28869590 30054458 30297969) Type 2 diabetes (young onset) and obesity ( 24465431) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Vitiligo ( 20410501 22951725 27723757) White matter integrity (bipolar disorder risk interaction) ( 23218918)
Interacting Genes		9 interacting genes: ACTN1 ATP5MF ATRAID MAGI1 MTNR1A SCRIB SHPRH TRIM21 VASP	12 interacting genes: BORCS6 EDARADD FBXW7 FDFT1 H3C1 H4C1 LPP RAD18 UBE2D1 UBE2N UBE2V2 YWHAG
Entrez ID		4026	257218
HPRD ID		02828	10476
Ensembl ID		ENSG00000145012	ENSG00000146414
Uniprot IDs		B7Z871 B7Z8W0 B7ZLW0 Q93052	B3KX98 Q149N8
PDB IDs			2M85 4QN1
Enriched GO Terms of Interacting Partners?		Glutamatergic Synapse Postsynapse Anchoring Junction Protein-containing Complex Organization Cell-cell Junction Cell Junction Cell Morphogenesis Cellular Component Assembly Synaptic Vesicle Endocytosis Presynaptic Endocytosis Negative Regulation Of Protein Metabolic Process Cell Projection Protein-containing Complex Assembly Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Protein-containing Complex Localization Regulation Of Receptor Internalization	Regulation Of Protein Polyubiquitination Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Protein Ubiquitination Protein Ubiquitination Postreplication Repair UBC13-MMS2 Complex Ubiquitin Conjugating Enzyme Complex Protein Modification By Small Protein Conjugation Regulation Of Protein Ubiquitination Post-translational Protein Modification TORC1 Signaling Negative Regulation Of TORC1 Signaling Positive Regulation Of Protein K63-linked Ubiquitination Ubiquitin-protein Transferase Activator Activity Regulation Of Post-translational Protein Modification TOR Signaling Protein Polyubiquitination Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Regulation Of Protein K63-linked Ubiquitination Regulation Of Protein Modification Process Positive Regulation Of Protein Modification Process Protein-containing Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process DNA Double-strand Break Processing Positive Regulation Of Protein Metabolic Process Regulation Of TOR Signaling Ubiquitin Conjugating Enzyme Activity Proteasomal Protein Catabolic Process DNA Repair Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Squalene Synthase [NAD(P)H] Activity Protein Catabolic Process Cellular Response To Nutrient Levels Protein Monoubiquitination Rad6-Rad18 Complex SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Chromosome Ubiquitin Protein Ligase Binding Protein K63-linked Ubiquitination DNA Metabolic Process Error-free Postreplication DNA Repair Negative Regulation Of Intracellular Signal Transduction Chromosome Organization Structural Constituent Of Chromatin DNA Damage Response
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