SON and TRIP6

Number of citations of the paper that reports this interaction (PMID 11782456)
41

Data Source:
HPRD (two hybrid)

		SON	TRIP6
Gene Name		SON DNA binding protein	thyroid hormone receptor interactor 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nuclear Speck	Nucleus Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion Interleukin-1 Receptor Complex
	Molecular Function	Nucleic Acid Binding DNA Binding RNA Binding Protein Binding Poly(A) RNA Binding RS Domain Binding	Interleukin-1 Receptor Binding Protein Binding Zinc Ion Binding Kinase Binding Poly(A) RNA Binding Thyroid Hormone Receptor Binding
	Biological Process	Microtubule Cytoskeleton Organization Cytokinesis MRNA Processing RNA Splicing Negative Regulation Of Apoptotic Process Regulation Of RNA Splicing Regulation Of Cell Cycle	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Release Of Cytoplasmic Sequestered NF-kappaB Positive Regulation Of Cell Migration Focal Adhesion Assembly
Pathways
Drugs
Diseases
GWAS			Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020)
Protein-Protein Interactions		6 interactors: PRPF40A SNIP1 TRIP6 VHL YWHAB YWHAG	105 interactors: ABI2 ADAMTSL4 AQP1 ARNT2 ATN1 ATP5O ATXN1 BCAR1 BYSL CATSPER1 CBLC CCL5 CEP57L1 CNTF CREB5 CTAG2 DHX37 DMRT3 DTX2 EXOC3-AS1 FAM124B FAM154A FAM46C FASLG FHL3 FRS3 GDPD5 GFI1B GNAI2 GSE1 HLA-DPB1 HOXA1 HOXA9 HOXB9 HYKK ILF3 INCA1 KIAA1683 KIF1A KIR2DL4 KLK15 KRTAP26-1 LMO2 LOC149950 LPAR2 MAPKBP1 MEMO1 METTL17 MSRB3 MVP NCK2 NEDD9 NEU4 NUP210 ODF1 OIP5 OTUB2 PDGFRB PDLIM4 PIN1 POM121 POM121L4P PPP1R16A PRKAA1 PRKAA2 PTK2 PTPN13 PXN RAD23A RERE RFX3 RHOA RHOQ RNF213 RNF214 SCRIB SIK3 SLC15A3 SLC25A6 SMAD1 SON SRC STAC STK16 SVIL SYNGAP1 TAB1 TCAF1 TEKT4 THRB TLR2 TMSB4X TPM3 TPM4 TRAF3IP2 TRAPPC2L TRIM29 TTLL10 TXN2 TXNDC5 VCL WT1-AS XRCC6BP1 YPEL3 ZBP1
Entrez ID		6651	7205
HPRD ID		01678	04242
Ensembl ID		ENSG00000159140	ENSG00000087077
Uniprot IDs		P18583	F2ZC06 Q15654
PDB IDs			1X61 2DLO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Intracellular Transport Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Mitochondrion Organization Regulation Of Intracellular Transport Regulation Of Mitochondrion Organization Regulation Of Establishment Of Protein Localization Intracellular Signal Transduction Positive Regulation Of Transport Regulation Of Protein Localization Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Apoptotic Signaling Pathway Cellular Response To Insulin Stimulus Release Of Cytoplasmic Sequestered NF-kappaB Negative Regulation Of Protein Dephosphorylation Regulation Of Cellular Localization Response To Insulin Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Signal Transduction Cellular Response To Peptide Negative Regulation Of Gene Expression Apoptotic Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Organelle Organization Protein Targeting Regulation Of Cell Death Response To Peptide Hormone Posttranscriptional Regulation Of Gene Expression Gene Expression Production Of MiRNAs Involved In Gene Silencing By MiRNA Cellular Response To Organonitrogen Compound Positive Regulation Of NF-kappaB Import Into Nucleus Response To Peptide Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cytoplasmic Sequestering Of Protein Hippo Signaling Cellular Response To Stimulus Cellular Response To Organic Substance RNA Processing Focal Adhesion Assembly Cellular Response To Hormone Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Cellular Component Organization Gene Silencing By MiRNA Cellular Response To DsRNA Positive Regulation Of Cell Death	Signal Complex Assembly Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Response To Organic Substance Regulation Of Signaling Actin Filament-based Process Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Movement Of Cell Or Subcellular Component Positive Regulation Of Intracellular Signal Transduction Response To Growth Factor Cytoskeleton Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction ERBB Signaling Pathway Cell Communication Cellular Process Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorylation Multicellular Organismal Development Regulation Of Apoptotic Process Response To Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Response To Transforming Growth Factor Beta Regulation Of Protein Phosphorylation Cellular Response To Stimulus Platelet Activation Response To Hormone Response To Stress Cellular Response To Growth Factor Stimulus Response To Wounding Regulation Of Protein Metabolic Process Regulation Of Cell Death Actin Cytoskeleton Organization Wound Healing Signaling Transforming Growth Factor Beta Receptor Signaling Pathway Organ Development Regulation Of Cell Motility Cell Motility Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Apoptotic Process
Tagcloud ?		adulthood bursting cerebellum confers declined earliest ed17 explant homogenates manifested neuroendocrine nr1 nr2b nr2c nr2d ontogenic oxytocin plastic pn14 pn21 pn7 postnatal pvn quantities rose sharp supraoptic unregulation vasopressin	adaptors ap competition dimerization discrete domains enables enhances example exerts focal glucocorticoid gr interacts intriguing isoform lim med1 mediating mediator negatively orchestrating promoters recruitment tethering thought thrap3 transrepression
Tagcloud (Difference) ?		adulthood bursting cerebellum confers declined earliest ed17 explant homogenates manifested neuroendocrine nr1 nr2b nr2c nr2d ontogenic oxytocin plastic pn14 pn21 pn7 postnatal pvn quantities rose sharp supraoptic unregulation vasopressin	adaptors ap competition dimerization discrete domains enables enhances example exerts focal glucocorticoid gr interacts intriguing isoform lim med1 mediating mediator negatively orchestrating promoters recruitment tethering thought thrap3 transrepression
Tagcloud (Intersection) ?