SON and VHL

Number of citations of the paper that reports this interaction (PMID 22234250)
1

Data Source:
BioGRID (pull down)

		SON	VHL
Gene Name		SON DNA binding protein	von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nuclear Speck	Nucleus Nucleoplasm Mitochondrion Endoplasmic Reticulum Cytosol Membrane Intermediate Filament Cytoskeleton
	Molecular Function	Nucleic Acid Binding DNA Binding RNA Binding Protein Binding Poly(A) RNA Binding RS Domain Binding	Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Enzyme Binding Ubiquitin Protein Ligase Activity
	Biological Process	Microtubule Cytoskeleton Organization Cytokinesis MRNA Processing RNA Splicing Negative Regulation Of Apoptotic Process Regulation Of RNA Splicing Regulation Of Cell Cycle	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis Regulation Of Transcription, DNA-templated Proteolysis Negative Regulation Of Cell Proliferation Protein Ubiquitination Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription, DNA-templated Protein Stabilization Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia
Pathways			Cellular response to hypoxia Antigen processing: Ubiquitination & Proteasome degradation Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: PRPF40A SNIP1 TRIP6 VHL YWHAB YWHAG	85 interactors: ACTB APP AR AURKA CAPN7 CAPZB CBR1 CBX1 CBX3 CCT3 CD44 CDC34 CHEK2 CLU CSNK2A1 CUL2 CUL5 DGKI DNAJA3 DVL2 E2F1 EEF1B2 EPAS1 FKBP8 FLNA FN1 HDAC1 HDAC2 HDAC3 HIF1A HIF1AN HIF3A HIST1H1C HIST1H2BL HIST4H4 HNRNPA2B1 HNRNPD HSPA5 HSPA8 JADE1 KIF2C KIF3A KLF4 LANCL1 MDFI NCL NR4A1 NR4A2 NR4A3 PDCD5 PLD1 POLR2G PRDX1 PRKCD PRKCI PRMT1 PRMT8 PSMC3 RB1CC1 RBPMS RBPMS2 RBX1 RNF139 RPL21 RPL5 RPS15A SARNP SAT2 SKP2 SLC2A1 SLC3A2 SON SP1 TCEB1 TCEB2 TRIM28 UBE2D1 USP20 USP33 UXT VAPB VBP1 YY1AP1 ZNF197 ZNF512B
Entrez ID		6651	7428
HPRD ID		01678	01905
Ensembl ID		ENSG00000159140
Uniprot IDs		P18583	P40337
PDB IDs			1LM8 1LQB 1VCB 3ZRC 3ZRF 3ZTC 3ZTD 3ZUN 4AJY 4AWJ 4B95 4B9K
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Intracellular Transport Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Mitochondrion Organization Regulation Of Intracellular Transport Regulation Of Mitochondrion Organization Regulation Of Establishment Of Protein Localization Intracellular Signal Transduction Positive Regulation Of Transport Regulation Of Protein Localization Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Apoptotic Signaling Pathway Cellular Response To Insulin Stimulus Release Of Cytoplasmic Sequestered NF-kappaB Negative Regulation Of Protein Dephosphorylation Regulation Of Cellular Localization Response To Insulin Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Signal Transduction Cellular Response To Peptide Negative Regulation Of Gene Expression Apoptotic Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Organelle Organization Protein Targeting Regulation Of Cell Death Response To Peptide Hormone Posttranscriptional Regulation Of Gene Expression Gene Expression Production Of MiRNAs Involved In Gene Silencing By MiRNA Cellular Response To Organonitrogen Compound Positive Regulation Of NF-kappaB Import Into Nucleus Response To Peptide Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cytoplasmic Sequestering Of Protein Hippo Signaling Cellular Response To Stimulus Cellular Response To Organic Substance RNA Processing Focal Adhesion Assembly Cellular Response To Hormone Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Cellular Component Organization Gene Silencing By MiRNA Cellular Response To DsRNA Positive Regulation Of Cell Death	Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Gene Expression Cellular Metabolic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription, DNA-templated RNA Metabolic Process Transcription, DNA-templated Regulation Of Cellular Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Metabolic Process Cellular Response To Stress Positive Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Nucleobase-containing Compound Metabolic Process Cellular Response To Oxygen Levels Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cell Death Nitrogen Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Blood Coagulation Positive Regulation Of Cellular Protein Metabolic Process Hemostasis Heterocycle Metabolic Process Positive Regulation Of Gene Expression Cellular Aromatic Compound Metabolic Process Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Body Fluid Levels Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Regulation Of Transcription From RNA Polymerase II Promoter Wound Healing Regulation Of Signal Transduction Response To Stimulus
Tagcloud ?		adulthood bursting cerebellum confers declined earliest ed17 explant homogenates manifested neuroendocrine nr1 nr2b nr2c nr2d ontogenic oxytocin plastic pn14 pn21 pn7 postnatal pvn quantities rose sharp supraoptic unregulation vasopressin	ankyrin attenuates bc belonging binds box collection degenerate elongation elongin hippel inhibiting initially interacting jak lindau motif multifunctional multiprotein participates pol repeat skp1 socs spry stat suppressor von wd
Tagcloud (Difference) ?		adulthood bursting cerebellum confers declined earliest ed17 explant homogenates manifested neuroendocrine nr1 nr2b nr2c nr2d ontogenic oxytocin plastic pn14 pn21 pn7 postnatal pvn quantities rose sharp supraoptic unregulation vasopressin	ankyrin attenuates bc belonging binds box collection degenerate elongation elongin hippel inhibiting initially interacting jak lindau motif multifunctional multiprotein participates pol repeat skp1 socs spry stat suppressor von wd
Tagcloud (Intersection) ?