ABCD4 and DLEU1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ABCD4	DLEU1
Gene Name		ATP-binding cassette, sub-family D (ALD), member 4	deleted in lymphocytic leukemia 1 (non-protein coding)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Membrane Integral Component Of Membrane ATP-binding Cassette (ABC) Transporter Complex
	Molecular Function	ATP Binding ATPase Activity, Coupled To Transmembrane Movement Of Substances
	Biological Process	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Cobalamin Metabolic Process Small Molecule Metabolic Process Transmembrane Transport
Pathways		Metabolism of vitamins and cofactors Defective GIF causes intrinsic factor deficiency Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective CUBN causes hereditary megaloblastic anemia 1 Cobalamin (Cbl, vitamin B12) transport and metabolism Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Orphan transporters Defects in cobalamin (B12) metabolism Defects in vitamin and cofactor metabolism
Drugs
Diseases
GWAS			Multiple sclerosis ( 21833088)
Protein-Protein Interactions		4 interactors: DLEU1 PEA15 SARAF XRCC6	19 interactors: ABCD4 ABCF3 ARL8B CCDC90B COPS6 EEF1A1 EEF1G GDF9 KAT5 KIAA1377 MED31 PSMA1 SETDB1 SHMT1 TLE1 TP53 TUBB4B UBR1 UTP14A
Entrez ID		5826	10301
HPRD ID		04446	16150
Ensembl ID		ENSG00000119688	ENSG00000176124
Uniprot IDs		F8W7M4 O14678
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Hyperosmotic Salinity Response Cellular Response To X-ray Establishment Of Integrated Proviral Latency Establishment Of Viral Latency Cellular Hyperosmotic Response Hyperosmotic Salinity Response Negative Regulation Of Glucose Import Cellular Response To Salt Stress DNA Ligation Negative Regulation Of Glucose Transport Regulation Of Store-operated Calcium Entry Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Hyperosmotic Response Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors V(D)J Recombination Cellular Response To DNA Damage Stimulus Cellular Response To Osmotic Stress Response To X-ray Response To Salt Stress Response To Morphine Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cellular Response To Ionizing Radiation	DNA Damage Response, Signal Transduction By P53 Class Mediator DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Signal Transduction In Response To DNA Damage DNA Damage Response, Signal Transduction Resulting In Transcription Signal Transduction By P53 Class Mediator Negative Regulation Of Fibroblast Proliferation Viral Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Mitotic Cell Cycle Process Negative Regulation Of Macromitophagy Cellular Response To Leucine Oocyte Growth Oligodendrocyte Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter Water-soluble Vitamin Metabolic Process Mitotic Cell Cycle Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic DNA Damage Checkpoint Negative Regulation Of Helicase Activity Regulation Of Fibroblast Proliferation Regulation Of Cell Cycle Arrest Cell Cycle Cellular Metabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Nitrogen Compound Metabolic Process Protein Tetramerization L-serine Catabolic Process Regulation Of Progesterone Secretion Vitamin Metabolic Process Carnitine Biosynthetic Process Positive Regulation Of Protein Modification Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Spindle Organization Positive Regulation Of Thymocyte Apoptotic Process Positive Regulation Of Cell Aging Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Metabolic Process Notch Signaling Pathway Transcription, DNA-templated
Tagcloud ?		b12 biophysical coa cofactor crosslinking detergent dilution homodimers impairing inactivating lmbd1 lmbrd1 lysosomal mals methionine methylmalonyl milieu mmachc mutase nanomolar plasmon protecting scattering sec solubilized spr vectorial vitamin whereby	10q23 11q22 12p13 13q14 17p13 21q22 2p23 5q32 6q21 7p12 7q21 8q24 9p13 9p21 9p24 acgh dleu2 ebf1 ikzf1 imbalances interrogate mir145a mir146a mir15a mlpa pax5 probemix uncovering undetected
Tagcloud (Difference) ?		b12 biophysical coa cofactor crosslinking detergent dilution homodimers impairing inactivating lmbd1 lmbrd1 lysosomal mals methionine methylmalonyl milieu mmachc mutase nanomolar plasmon protecting scattering sec solubilized spr vectorial vitamin whereby	10q23 11q22 12p13 13q14 17p13 21q22 2p23 5q32 6q21 7p12 7q21 8q24 9p13 9p21 9p24 acgh dleu2 ebf1 ikzf1 imbalances interrogate mir145a mir146a mir15a mlpa pax5 probemix uncovering undetected
Tagcloud (Intersection) ?