ABCD4 and SARAF

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		ABCD4	SARAF
Gene Name		ATP-binding cassette, sub-family D (ALD), member 4	store-operated calcium entry-associated regulatory factor
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Membrane Integral Component Of Membrane ATP-binding Cassette (ABC) Transporter Complex	Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	ATP Binding ATPase Activity, Coupled To Transmembrane Movement Of Substances	Protein Binding
	Biological Process	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Cobalamin Metabolic Process Small Molecule Metabolic Process Transmembrane Transport	Calcium Ion Transport Regulation Of Store-operated Calcium Entry
Pathways		Metabolism of vitamins and cofactors Defective GIF causes intrinsic factor deficiency Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective CUBN causes hereditary megaloblastic anemia 1 Cobalamin (Cbl, vitamin B12) transport and metabolism Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Orphan transporters Defects in cobalamin (B12) metabolism Defects in vitamin and cofactor metabolism
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: DLEU1 PEA15 SARAF XRCC6	5 interactors: ABCD4 IFIT5 RIBC2 SAT1 SNX15
Entrez ID		5826	51669
HPRD ID		04446	08651
Ensembl ID		ENSG00000119688	ENSG00000133872
Uniprot IDs		F8W7M4 O14678	Q96BY9
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Hyperosmotic Salinity Response Cellular Response To X-ray Establishment Of Integrated Proviral Latency Establishment Of Viral Latency Cellular Hyperosmotic Response Hyperosmotic Salinity Response Negative Regulation Of Glucose Import Cellular Response To Salt Stress DNA Ligation Negative Regulation Of Glucose Transport Regulation Of Store-operated Calcium Entry Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Hyperosmotic Response Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors V(D)J Recombination Cellular Response To DNA Damage Stimulus Cellular Response To Osmotic Stress Response To X-ray Response To Salt Stress Response To Morphine Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cellular Response To Ionizing Radiation	Spermidine Acetylation Putrescine Catabolic Process Oxalate Transport Polyamine Catabolic Process 3'-phosphoadenosine 5'-phosphosulfate Biosynthetic Process Neurotransmitter Uptake 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Polyamine Biosynthetic Process Cobalamin Metabolic Process Amine Biosynthetic Process Polyamine Metabolic Process Sulfate Transmembrane Transport Sulfate Transport Neutral Amino Acid Transport
Tagcloud ?		b12 biophysical coa cofactor crosslinking detergent dilution homodimers impairing inactivating lmbd1 lmbrd1 lysosomal mals methionine methylmalonyl milieu mmachc mutase nanomolar plasmon protecting scattering sec solubilized spr vectorial vitamin whereby
Tagcloud (Difference) ?		b12 biophysical coa cofactor crosslinking detergent dilution homodimers impairing inactivating lmbd1 lmbrd1 lysosomal mals methionine methylmalonyl milieu mmachc mutase nanomolar plasmon protecting scattering sec solubilized spr vectorial vitamin whereby
Tagcloud (Intersection) ?