GOPC and LCLAT1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		GOPC	LCLAT1
Description		golgi associated PDZ and coiled-coil motif containing	lysocardiolipin acyltransferase 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosomal Membrane Golgi Apparatus Plasma Membrane Postsynaptic Density Membrane Trans-Golgi Network Transport Vesicle Dendrite Golgi-associated Vesicle Membrane Protein-containing Complex Cell Projection Synapse	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Endomembrane System Membrane
	Molecular Function	Protein Binding Identical Protein Binding Transmembrane Transporter Binding Molecular Sequestering Activity	1-acylglycerol-3-phosphate O-acyltransferase Activity Protein Binding O-acyltransferase Activity Transferase Activity Acyltransferase Activity
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Negative Regulation Of Anion Channel Activity Protein Transport Apical Protein Localization Negative Regulation Of Protein Localization To Cell Surface	Lipid Metabolic Process Phosphatidic Acid Biosynthetic Process Phospholipid Biosynthetic Process CDP-diacylglycerol Biosynthetic Process Cardiolipin Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling
Pathways		RHO GTPases regulate CFTR trafficking RHOQ GTPase cycle	Acyl chain remodeling of CL Synthesis of PA
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015) Colorectal cancer ( 23266556) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Facial emotion recognition (fearful faces) ( 28608620) Mild obesity-related type 2 diabetes ( 34737425) Night sleep phenotypes ( 27126917)	Liver enzyme levels (alkaline phosphatase) ( 33972514) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		71 interacting genes: ABCA1 ADRB1 AKIRIN1 ASIC3 BATF BECN1 C17orf67 CCDC102B CCDC198 CD300C CDKN2C CEBPA CERCAM CFTR CLCN3 CRHR1 CSPG5 DLEU1 DPYD FAM90A1 FAM9B FOSL2 FZD5 FZD8 GEM GOLGA3 GRID1 GRID2 HCK HNRNPLL IGHG3 JUN KPNA1 LCLAT1 MORN4 MRPL1 MYLK MYOCD NOTCH1 NUP62 OSBP2 PARK7 PID1 PPP1R18 PWWP3A RALGAPB RELA RHOQ RNF183 RNF220 RPL13AP17 RPS6KA1 RTKN SEMA4G SLC25A18 SNX31 SPATA8 SSTR5 STARD3 STX6 TGFBR2 UBE3A VIM VTN ZBTB49 ZDHHC1 ZNF564 ZNF581 ZNF587 ZNF835 ZSCAN1	3 interacting genes: GOPC LNX1 PICK1
Entrez ID		57120	253558
HPRD ID		06024	17458
Ensembl ID		ENSG00000047932	ENSG00000172954
Uniprot IDs		Q9HD26	B4DM26 B4DYR5 Q6UWP7
PDB IDs		2DC2 2LOB 4E34 4E35 4JOE 4JOF 4JOG 4JOH 4JOJ 4JOK 4JOP 4JOR 4K6Y 4K72 4K75 4K76 4K78 4NMO 4NMP 4NMQ 4NMR 4NMS 4NMT 4NMV 4Q6H 4Q6S 5IC3 5K4F 6OV7 6V84 6XNJ 7JZO 7JZP 7JZQ 7JZR
Enriched GO Terms of Interacting Partners?		Response To Lipid Phagocytic Vesicle PDZ Domain Binding Golgi-associated Vesicle Membrane Response To Xenobiotic Stimulus Positive Regulation Of Cellular Component Biogenesis Phagocytosis, Engulfment Response To Vitamin Negative Regulation Of Cell Population Proliferation Regeneration Liver Development Response To Hormone Positive Regulation Of Transcription By RNA Polymerase II Response To Steroid Hormone Positive Regulation Of Reactive Oxygen Species Metabolic Process Glutamatergic Synapse Transcription Factor AP-1 Complex Trans-synaptic Protein Complex AMPA Glutamate Receptor Activity Scaffold Protein Binding SMAD Protein Signal Transduction Postsynapse To Nucleus Signaling Pathway Response To Muramyl Dipeptide Membrane Hyperpolarization Negative Regulation Of Skeletal Muscle Cell Differentiation Myeloid Leukocyte Differentiation Hormone-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Mononuclear Cell Differentiation Regulation Of Stem Cell Proliferation Signal Transduction Organic Hydroxy Compound Transport Integrated Stress Response Signaling Synaptic Signaling Via Neuropeptide Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Cell Adhesion Molecule Production	Negative Regulation Of Anion Channel Activity Postsynaptic Density Membrane Curvature Sensor Activity Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Identical Protein Binding Negative Regulation Of Actin Nucleation Localization Within Membrane Neuronal Ion Channel Clustering Arp2/3 Complex Binding Dendritic Spine Maintenance Long-term Synaptic Depression Negative Regulation Of Protein Localization To Cell Surface Regulation Of Monoatomic Anion Transport Molecular Sequestering Activity Golgi-associated Vesicle Membrane Trans-Golgi Network Transport Vesicle Apical Protein Localization Synapse Maturation Positive Regulation Of Receptor Internalization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Monoamine Transport Negative Regulation Of Transporter Activity Dendritic Spine Organization Regulation Of Actin Nucleation Negative Regulation Of Synaptic Transmission Regulation Of Protein Localization To Cell Surface Cellular Response To Glucose Starvation Receptor Clustering Neuron Projection Organization Protein Kinase C Binding Postsynapse Organization Synapse Regulation Of Protein Localization Hippocampal Mossy Fiber To CA3 Synapse Positive Regulation Of Receptor-mediated Endocytosis
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