GOPC and CLCN3

Number of citations of the paper that reports this interaction (PubMedID 9843494)
56

Data Source:
HPRD (in vitro, in vivo)

		GOPC	CLCN3
Description		golgi associated PDZ and coiled-coil motif containing	chloride voltage-gated channel 3
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosomal Membrane Golgi Apparatus Plasma Membrane Postsynaptic Density Membrane Trans-Golgi Network Transport Vesicle Dendrite Golgi-associated Vesicle Membrane Protein-containing Complex Cell Projection Synapse	Golgi Membrane Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Golgi Apparatus Plasma Membrane Synaptic Vesicle External Side Of Plasma Membrane Cell Surface Endosome Membrane Vesicle Membrane Membrane Secretory Granule Synaptic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Ruffle Membrane Specific Granule Cell Projection Axon Terminus Phagocytic Vesicle Recycling Endosome Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Protein Binding Identical Protein Binding Transmembrane Transporter Binding Molecular Sequestering Activity	Nucleotide Binding Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding ATP Binding Chloride Transmembrane Transporter Activity Antiporter Activity PDZ Domain Binding Chloride:proton Antiporter Activity Volume-sensitive Chloride Channel Activity
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Negative Regulation Of Anion Channel Activity Protein Transport Apical Protein Localization Negative Regulation Of Protein Localization To Cell Surface	Monoatomic Ion Transport Chloride Transport Regulation Of PH Phagocytosis, Engulfment Adult Locomotory Behavior Synaptic Transmission, Glutamatergic Photoreceptor Cell Maintenance Negative Regulation Of Cell Volume Endosomal Lumen Acidification Synaptic Transmission, GABAergic Transmembrane Transport Neuron Cellular Homeostasis Synaptic Vesicle Lumen Acidification Chloride Transmembrane Transport Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
Pathways		RHO GTPases regulate CFTR trafficking RHOQ GTPase cycle	Stimuli-sensing channels
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015) Colorectal cancer ( 23266556) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Facial emotion recognition (fearful faces) ( 28608620) Mild obesity-related type 2 diabetes ( 34737425) Night sleep phenotypes ( 27126917)	Autism spectrum disorder or schizophrenia ( 28540026) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Schizophrenia ( 25056061 28991256 29483656 30285260)
Interacting Genes		71 interacting genes: ABCA1 ADRB1 AKIRIN1 ASIC3 BATF BECN1 C17orf67 CCDC102B CCDC198 CD300C CDKN2C CEBPA CERCAM CFTR CLCN3 CRHR1 CSPG5 DLEU1 DPYD FAM90A1 FAM9B FOSL2 FZD5 FZD8 GEM GOLGA3 GRID1 GRID2 HCK HNRNPLL IGHG3 JUN KPNA1 LCLAT1 MORN4 MRPL1 MYLK MYOCD NOTCH1 NUP62 OSBP2 PARK7 PID1 PPP1R18 PWWP3A RALGAPB RELA RHOQ RNF183 RNF220 RPL13AP17 RPS6KA1 RTKN SEMA4G SLC25A18 SNX31 SPATA8 SSTR5 STARD3 STX6 TGFBR2 UBE3A VIM VTN ZBTB49 ZDHHC1 ZNF564 ZNF581 ZNF587 ZNF835 ZSCAN1	6 interacting genes: CFTR DNAJC5 GOPC HSPB1 NHERF1 PDZK1
Entrez ID		57120	1182
HPRD ID		06024	02785
Ensembl ID		ENSG00000047932	ENSG00000109572
Uniprot IDs		Q9HD26	B3KXK0 E9PE15 P51790
PDB IDs		2DC2 2LOB 4E34 4E35 4JOE 4JOF 4JOG 4JOH 4JOJ 4JOK 4JOP 4JOR 4K6Y 4K72 4K75 4K76 4K78 4NMO 4NMP 4NMQ 4NMR 4NMS 4NMT 4NMV 4Q6H 4Q6S 5IC3 5K4F 6OV7 6V84 6XNJ 7JZO 7JZP 7JZQ 7JZR
Enriched GO Terms of Interacting Partners?		Response To Lipid Phagocytic Vesicle PDZ Domain Binding Golgi-associated Vesicle Membrane Response To Xenobiotic Stimulus Positive Regulation Of Cellular Component Biogenesis Phagocytosis, Engulfment Response To Vitamin Negative Regulation Of Cell Population Proliferation Regeneration Liver Development Response To Hormone Positive Regulation Of Transcription By RNA Polymerase II Response To Steroid Hormone Positive Regulation Of Reactive Oxygen Species Metabolic Process Glutamatergic Synapse Transcription Factor AP-1 Complex Trans-synaptic Protein Complex AMPA Glutamate Receptor Activity Scaffold Protein Binding SMAD Protein Signal Transduction Postsynapse To Nucleus Signaling Pathway Response To Muramyl Dipeptide Membrane Hyperpolarization Negative Regulation Of Skeletal Muscle Cell Differentiation Myeloid Leukocyte Differentiation Hormone-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Mononuclear Cell Differentiation Regulation Of Stem Cell Proliferation Signal Transduction Organic Hydroxy Compound Transport Integrated Stress Response Signaling Synaptic Signaling Via Neuropeptide Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Cell Adhesion Molecule Production	Regulation Of Monoatomic Anion Transport PDZ Domain Binding Chloride Channel Regulator Activity Regulation Of Monoatomic Ion Transport Golgi-associated Vesicle Membrane 14-3-3 Protein Binding Apical Plasma Membrane Regulation Of Transport Lysosomal Membrane Microvillus Membrane Protein-membrane Adaptor Activity Vesicle Docking Involved In Exocytosis Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Negative Regulation Of Protein Kinase C Signaling Metanephric Glomerular Mesangial Cell Development Renal Phosphate Ion Absorption Negative Regulation Of Anion Channel Activity
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