EIF3J and GNB5

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		EIF3J	GNB5
Description		eukaryotic translation initiation factor 3 subunit J	G protein subunit beta 5
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GO Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex	Nucleus Cytoplasm Cytosol Heterotrimeric G-protein Complex Plasma Membrane Membrane Dendrite Presynaptic Membrane Synapse Postsynaptic Membrane Cell Tip Parallel Fiber To Purkinje Cell Synapse Presynapse GTPase Activator Complex
	Molecular Function	Translation Initiation Factor Activity Protein Binding Identical Protein Binding	GTPase Activity GTPase Activator Activity Protein Binding Signaling Receptor Complex Adaptor Activity G-protein Gamma-subunit Binding Protein-folding Chaperone Binding
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Translational Initiation	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway Light Adaption Positive Regulation Of GTPase Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Dark Adaptation
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	Activation of G protein gated Potassium channels G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs
Diseases
GWAS		Anti-Toxoplasma gondii IgG seropositivity ( 30610941)	Lewy body disease ( 25188341)
Interacting Genes		16 interacting genes: ABCE1 CASP3 CSNK2A1 EIF3A EIF3B EIF3C EIF3D EIF3K GNB5 GOLM1 MAGED1 METTL3 NFE2L2 SIAH1 TADA3 TPD52L1	27 interacting genes: ANXA7 APP BNIP3L CDKN1A CSNK2B DRD2 E2F2 EIF3J GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNGT1 MCM2 MVD NR6A1 OLFM2 PSD PSMD4 RGS11 RGS6 RGS7 RGS9 RPA1 TSC22D1
Entrez ID		8669	10681
HPRD ID		04883	09191
Ensembl ID		ENSG00000104131	ENSG00000069966
Uniprot IDs		O75822	O14775
PDB IDs		2KRB 3BPJ 6YBW 6ZMW 6ZVJ	7EWP 7EWR 8SG8 8SG9 8SGC 8SGL 8SH9 8SHA 8SHD 8SHE 8SHF 8SHG 8SHL 8SHN 8SHO 8SHP 8SHQ 8SHT
Enriched GO Terms of Interacting Partners?		Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 48S Preinitiation Complex Eukaryotic 43S Preinitiation Complex Translational Initiation Cytoplasmic Translational Initiation Translation Initiation Factor Activity Viral Translational Termination-reinitiation Eukaryotic Translation Initiation Factor 3 Complex, EIF3m IRES-dependent Viral Translational Initiation Translation Protein-RNA Complex Assembly Regulation Of Translation Regulation Of Protein Metabolic Process Regulation Of Translational Initiation Post-transcriptional Regulation Of Gene Expression Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Cytosol Rhythmic Process Regulation Of Hematopoietic Stem Cell Differentiation Regulation Of Primary Metabolic Process Macromolecule Biosynthetic Process Protein Catabolic Process Translation Initiation Factor Binding Execution Phase Of Apoptosis Regulation Of Protein Stability Positive Regulation Of Apoptotic Signaling Pathway Viral Process Positive Regulation Of Amide Metabolic Process Regulation Of Hematopoietic Progenitor Cell Differentiation Macromolecule Metabolic Process Positive Regulation Of Glutathione Biosynthetic Process Negative Regulation Of Endoribonuclease Activity GTPase Activator Complex G-protein Gamma-subunit Binding Cytoplasm Protein-containing Complex Organization Regulation Of Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Phospholipase A2 Activator Activity Regulation Of Glutathione Biosynthetic Process Aflatoxin Catabolic Process Endoribonuclease Inhibitor Activity Regulation Of Endoribonuclease Activity RNA Binding	G-protein Beta-subunit Binding Heterotrimeric G-protein Complex G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway GTPase Activity Signal Transduction G Protein-coupled Dopamine Receptor Signaling Pathway Plasma Membrane Synapse Response To Light Stimulus Neuron Projection Cellular Response To Catecholamine Stimulus Regulation Of Neurotransmitter Uptake Response To Catecholamine Dendrite Positive Regulation Of Long-term Synaptic Potentiation Molecular Function Activator Activity Protein Serine/threonine Kinase Binding Response To Radiation GTPase Activator Activity Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Receptor Internalization G-protein Alpha-subunit Binding
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