EIF3J

Description		eukaryotic translation initiation factor 3 subunit J
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GO Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex
	Molecular Function	Translation Initiation Factor Activity Protein Binding Identical Protein Binding
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Translational Initiation
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Anti-Toxoplasma gondii IgG seropositivity ( 30610941)
Interacting Genes		16 interacting genes: ABCE1 CASP3 CSNK2A1 EIF3A EIF3B EIF3C EIF3D EIF3K GNB5 GOLM1 MAGED1 METTL3 NFE2L2 SIAH1 TADA3 TPD52L1
Entrez ID		8669
HPRD ID		04883
Ensembl ID		ENSG00000104131
Uniprot IDs		O75822
PDB IDs		2KRB 3BPJ 6YBW 6ZMW 6ZVJ
Enriched GO Terms of Interacting Partners?		Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 48S Preinitiation Complex Eukaryotic 43S Preinitiation Complex Translational Initiation Cytoplasmic Translational Initiation Translation Initiation Factor Activity Viral Translational Termination-reinitiation Eukaryotic Translation Initiation Factor 3 Complex, EIF3m IRES-dependent Viral Translational Initiation Translation Protein-RNA Complex Assembly Regulation Of Translation Regulation Of Protein Metabolic Process Regulation Of Translational Initiation Post-transcriptional Regulation Of Gene Expression Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Cytosol Rhythmic Process Regulation Of Hematopoietic Stem Cell Differentiation Regulation Of Primary Metabolic Process Macromolecule Biosynthetic Process Protein Catabolic Process Translation Initiation Factor Binding Execution Phase Of Apoptosis Regulation Of Protein Stability Positive Regulation Of Apoptotic Signaling Pathway Viral Process Positive Regulation Of Amide Metabolic Process Regulation Of Hematopoietic Progenitor Cell Differentiation Macromolecule Metabolic Process Positive Regulation Of Glutathione Biosynthetic Process Negative Regulation Of Endoribonuclease Activity GTPase Activator Complex G-protein Gamma-subunit Binding Cytoplasm Protein-containing Complex Organization Regulation Of Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Phospholipase A2 Activator Activity Regulation Of Glutathione Biosynthetic Process Aflatoxin Catabolic Process Endoribonuclease Inhibitor Activity Regulation Of Endoribonuclease Activity RNA Binding
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