EIF3J and EIF3D

Number of citations of the paper that reports this interaction (PMID 22190034)
87

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		EIF3J	EIF3D
Gene Name		eukaryotic translation initiation factor 3, subunit J	eukaryotic translation initiation factor 3, subunit D
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Eukaryotic Translation Initiation Factor 3 Complex, EIF3m
	Molecular Function	Translation Initiation Factor Activity Protein Binding	Translation Initiation Factor Activity Protein Binding Poly(A) RNA Binding
	Biological Process	Formation Of Translation Preinitiation Complex Cytoplasmic Translation Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process	Formation Of Translation Preinitiation Complex Formation Of Cytoplasmic Translation Initiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process
Pathways		Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression	Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: CASP3 CSNK2A1 EIF3A EIF3B EIF3C EIF3D EIF3K GNB5 GOLM1 MAGED1 SIAH1 TADA3 TPD52L1	12 interactors: BEND5 DNAJB11 EIF3G EIF3J EIF3L EIF5 HOMER3 LZTS2 PHLDA1 REL SAT1 TRIM27
Entrez ID		8669	8664
HPRD ID		04883	04888
Ensembl ID		ENSG00000104131	ENSG00000100353
Uniprot IDs		O75822	B4DVY1 O15371
PDB IDs		2KRB 3BPJ
Enriched GO Terms of Interacting Partners?		Formation Of Translation Preinitiation Complex Regulation Of Translational Initiation Posttranscriptional Regulation Of Gene Expression Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Ribonucleoprotein Complex Assembly Translational Initiation Regulation Of Translation Formation Of Cytoplasmic Translation Initiation Complex Ribonucleoprotein Complex Biogenesis Cytoplasmic Translational Initiation Regulation Of Metabolic Process Cellular Macromolecular Complex Assembly Translation Cytoplasmic Translation Apoptotic Process Programmed Cell Death Cell Death Positive Regulation Of Apoptotic Signaling Pathway Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Gene Expression Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Neuron Apoptotic Process Protein Metabolic Process Neuron Death Cellular Protein Metabolic Process Regulation Of Apoptotic Process Regulation Of Cell Death Gene Expression Regulation Of Endopeptidase Activity Cellular Macromolecule Biosynthetic Process Regulation Of Peptidase Activity Macromolecule Biosynthetic Process Regulation Of Cellular Process Regulation Of Protein Phosphorylation Regulation Of Tubulin Deacetylation Cellular Component Assembly Regulation Of Protein Stability Negative Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Protein Metabolic Process Glial Cell Apoptotic Process Positive Regulation Of Signal Transduction Regulation Of Apoptotic DNA Fragmentation Regulation Of Phosphorylation Mature Ribosome Assembly Cell Cycle	Regulation Of Translational Initiation Formation Of Translation Preinitiation Complex Translational Initiation Regulation Of Translation Regulation Of Protein Metabolic Process Posttranscriptional Regulation Of Gene Expression Ribonucleoprotein Complex Assembly Regulation Of Cellular Protein Metabolic Process Cellular Macromolecular Complex Assembly Translation Biosynthetic Process Cellular Macromolecule Biosynthetic Process Ribonucleoprotein Complex Biogenesis Macromolecule Biosynthetic Process FasL Biosynthetic Process Regulation Of Cellular Process Spermidine Acetylation Negative Regulation Of Interleukin-2 Secretion Cellular Component Assembly Putrescine Catabolic Process Cytokine Production Gene Expression Oxalate Transport Polyamine Catabolic Process Negative Regulation Of Calcium Ion Import 3'-phosphoadenosine 5'-phosphosulfate Biosynthetic Process Regulation Of Calcium Ion Transport Interferon-gamma Secretion Spindle Midzone Assembly Protein Metabolic Process Positive Regulation Of Interleukin-12 Biosynthetic Process Neurotransmitter Uptake Microtubule Severing
Tagcloud ?		3a apart bindings binds carboxyl concurrently consisting docking eif3a eif3b eif3g eif3i exclusive exist indirectly mutually noncanonical participates perform purification solved spectrin subcomplex subcomplexes tandem translation translational tumorigenesis	accomplishment alters arise checkpoint chronically cofilin deregulation description elav elusive g2 hdv hek hepatitis hepatocellular hspe interactor isotope manuscript mimic pathogenicity probable proteome proteomes proteomics pyruvate replication sigma transportin
Tagcloud (Difference) ?		3a apart bindings binds carboxyl concurrently consisting docking eif3a eif3b eif3g eif3i exclusive exist indirectly mutually noncanonical participates perform purification solved spectrin subcomplex subcomplexes tandem translation translational tumorigenesis	accomplishment alters arise checkpoint chronically cofilin deregulation description elav elusive g2 hdv hek hepatitis hepatocellular hspe interactor isotope manuscript mimic pathogenicity probable proteome proteomes proteomics pyruvate replication sigma transportin
Tagcloud (Intersection) ?