GNB5 and OLFM2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		GNB5	OLFM2
Gene Name		guanine nucleotide binding protein (G protein), beta 5	olfactomedin 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Plasma Membrane	Extracellular Region Cell Junction Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex Synapse
	Molecular Function	GTPase Activity Signal Transducer Activity Protein Binding G-protein Gamma-subunit Binding Chaperone Binding
	Biological Process	Signal Transduction Phototransduction, Visible Light Metabolic Process Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Negative Regulation Of Voltage-gated Calcium Channel Activity	Protein Secretion
Pathways		G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Glucagon-type ligand receptors Signal amplification Signaling by Wnt G beta:gamma signalling through PLC beta Metabolic disorders of biological oxidation enzymes G beta:gamma signalling through PI3Kgamma Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (12/13) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Class B/2 (Secretin family receptors) ADP signalling through P2Y purinoceptor 12 Prostacyclin signalling through prostacyclin receptor G-protein beta:gamma signalling Vasopressin regulates renal water homeostasis via Aquaporins Opioid Signalling Regulation of insulin secretion Activation of Kainate Receptors upon glutamate binding GPCR ligand binding Aquaporin-mediated transport beta-catenin independent WNT signaling Adrenaline,noradrenaline inhibits insulin secretion Thrombin signalling through proteinase activated receptors (PARs) G alpha (q) signalling events Presynaptic function of Kainate receptors GPCR downstream signaling Platelet homeostasis Ca2+ pathway G-protein activation Platelet activation, signaling and aggregation Transmission across Chemical Synapses
Drugs
Diseases
GWAS			Menarche (age at onset) ( 21102462)
Protein-Protein Interactions		26 interactors: ANXA7 APP BNIP3L CDKN1A CSNK2B E2F2 EIF3J GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNGT1 MCM2 MVD NR6A1 OLFM2 PSD PSMD4 RGS11 RGS6 RGS7 RGS9 RPA1 TSC22D1	11 interactors: BLOC1S6 EIF1 FANCF GNB5 KRTAP10-3 NBAS PKM ROBO2 RPS6 SRSF5 ST13
Entrez ID		10681	93145
HPRD ID		09191	10127
Ensembl ID		ENSG00000069966	ENSG00000105088
Uniprot IDs		B3KWS4 O14775	K7EIS8 O95897
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Glucagon Stimulus Response To Glucagon Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway Response To Hormone Cellular Response To Stimulus Signal Transduction Cellular Response To Hormone Stimulus Signaling Cell Communication Response To Stimulus Regulation Of Cellular Process Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Energy Derivation By Oxidation Of Organic Compounds Cell Surface Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Response To Organic Substance Generation Of Precursor Metabolites And Energy Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Signal Transduction Cellular Response To Organic Substance Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Response To Organonitrogen Compound G1/S Transition Of Mitotic Cell Cycle Synaptic Transmission Regulation Of Signaling Mitotic Cell Cycle Cellular Response To Light Stimulus Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Signal Transduction By P53 Class Mediator Regulation Of Metabolic Process Cell-cell Signaling Regulation Of Rhodopsin Mediated Signaling Pathway Positive Regulation Of Metabolic Process Response To Light Stimulus DNA Strand Elongation Involved In DNA Replication Cellular Process Cellular Response To Radiation Apoptotic Process DNA Strand Elongation Small Molecule Metabolic Process Rhodopsin Mediated Signaling Pathway	Ovulation Cycle Process Negative Regulation Of Negative Chemotaxis Female Gonad Development Reproductive Structure Development Reproductive System Development Ovulation Cycle Development Of Primary Female Sexual Characteristics MRNA Metabolic Process Apoptotic Process Involved In Luteolysis Negative Regulation Of Protein Refolding Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Negative Chemotaxis Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Axon Midline Choice Point Recognition Chaperone Cofactor-dependent Protein Refolding Luteolysis Ribonucleoprotein Complex Assembly Negative Regulation Of Voltage-gated Calcium Channel Activity Oogenesis Stage Activation-induced Cell Death Of T Cells Secretion Of Lysosomal Enzymes Intracellular Transport Cytoplasmic Transport RNA Catabolic Process Axon Choice Point Recognition Developmental Process Involved In Reproduction Pigment Granule Maturation Synaptic Vesicle Docking Endosome To Melanosome Transport Multicellular Organismal Reproductive Process Olfactory Bulb Interneuron Development T Cell Proliferation Involved In Immune Response Gonad Development Translational Initiation Development Of Primary Sexual Characteristics Cellular Pigment Accumulation Multicellular Organism Reproduction Ribosomal Small Subunit Assembly Dosage Compensation By Inactivation Of X Chromosome Golgi Vesicle Transport Dosage Compensation Positive Regulation Of Pigment Cell Differentiation
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