GNB5 and RGS9

Number of citations of the paper that reports this interaction (PMID 12119397)
60

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		GNB5	RGS9
Gene Name		guanine nucleotide binding protein (G protein), beta 5	regulator of G-protein signaling 9
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Plasma Membrane	Nucleus Cytoplasm Heterotrimeric G-protein Complex Plasma Membrane
	Molecular Function	GTPase Activity Signal Transducer Activity Protein Binding G-protein Gamma-subunit Binding Chaperone Binding	Signal Transducer Activity GTPase Activator Activity Protein Complex Binding
	Biological Process	Signal Transduction Phototransduction, Visible Light Metabolic Process Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Negative Regulation Of Voltage-gated Calcium Channel Activity	Dopamine Receptor Signaling Pathway Nervous System Development Visual Perception Phototransduction, Visible Light Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Intracellular Signal Transduction Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity Response To Estrogen
Pathways		G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Glucagon-type ligand receptors Signal amplification Signaling by Wnt G beta:gamma signalling through PLC beta Metabolic disorders of biological oxidation enzymes G beta:gamma signalling through PI3Kgamma Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (12/13) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Class B/2 (Secretin family receptors) ADP signalling through P2Y purinoceptor 12 Prostacyclin signalling through prostacyclin receptor G-protein beta:gamma signalling Vasopressin regulates renal water homeostasis via Aquaporins Opioid Signalling Regulation of insulin secretion Activation of Kainate Receptors upon glutamate binding GPCR ligand binding Aquaporin-mediated transport beta-catenin independent WNT signaling Adrenaline,noradrenaline inhibits insulin secretion Thrombin signalling through proteinase activated receptors (PARs) G alpha (q) signalling events Presynaptic function of Kainate receptors GPCR downstream signaling Platelet homeostasis Ca2+ pathway G-protein activation Platelet activation, signaling and aggregation Transmission across Chemical Synapses	Signaling by GPCR GPCR downstream signaling G alpha (i) signalling events
Drugs
Diseases
GWAS
Protein-Protein Interactions		26 interactors: ANXA7 APP BNIP3L CDKN1A CSNK2B E2F2 EIF3J GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNGT1 MCM2 MVD NR6A1 OLFM2 PSD PSMD4 RGS11 RGS6 RGS7 RGS9 RPA1 TSC22D1	5 interactors: ADRB2 GNAT1 GNB5 GUCY2D RGS9BP
Entrez ID		10681	8787
HPRD ID		09191	04962
Ensembl ID		ENSG00000069966	ENSG00000108370
Uniprot IDs		B3KWS4 O14775	A8K1G1 O75916
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Glucagon Stimulus Response To Glucagon Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway Response To Hormone Cellular Response To Stimulus Signal Transduction Cellular Response To Hormone Stimulus Signaling Cell Communication Response To Stimulus Regulation Of Cellular Process Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Energy Derivation By Oxidation Of Organic Compounds Cell Surface Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Response To Organic Substance Generation Of Precursor Metabolites And Energy Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Signal Transduction Cellular Response To Organic Substance Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Response To Organonitrogen Compound G1/S Transition Of Mitotic Cell Cycle Synaptic Transmission Regulation Of Signaling Mitotic Cell Cycle Cellular Response To Light Stimulus Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Signal Transduction By P53 Class Mediator Regulation Of Metabolic Process Cell-cell Signaling Regulation Of Rhodopsin Mediated Signaling Pathway Positive Regulation Of Metabolic Process Response To Light Stimulus DNA Strand Elongation Involved In DNA Replication Cellular Process Cellular Response To Radiation Apoptotic Process DNA Strand Elongation Small Molecule Metabolic Process Rhodopsin Mediated Signaling Pathway	Regulation Of Rhodopsin Mediated Signaling Pathway Rhodopsin Mediated Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Phototransduction, Visible Light Detection Of Visible Light Cellular Response To Light Stimulus Phototransduction Detection Of Light Stimulus Cellular Response To Radiation Detection Of Abiotic Stimulus Response To Light Stimulus Response To Abiotic Stimulus G-protein Coupled Receptor Signaling Pathway Response To Radiation Detection Of Stimulus Response To External Stimulus Detection Of Light Stimulus Involved In Visual Perception Visual Perception Sensory Perception Of Light Stimulus Regulation Of Signal Transduction Regulation Of Signaling Cell Surface Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Sensory Perception G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Signal Transduction Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Vasodilation By Norepinephrine-epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure Signaling Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Cell Communication Neurological System Process Negative Regulation Of Voltage-gated Calcium Channel Activity Sensory Perception Of Umami Taste Heat Generation Diet Induced Thermogenesis Cellular Response To Stimulus Receptor Guanylyl Cyclase Signaling Pathway Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Cellular Response To Electrical Stimulus Response To Light Intensity Detection Of Stimulus Involved In Sensory Perception Negative Regulation Of Smooth Muscle Contraction Adrenergic Receptor Signaling Pathway Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Response To Dietary Excess Negative Regulation Of Cation Channel Activity CGMP Biosynthetic Process
Tagcloud ?			0mg 5months accumulated amphetamine caloric calorimetry consumption dark dioxide expenditure factoring hour indicative indirect influences ko littermates locomotor male modulates opioid psychostimulant respective sensitization striatum utilize weights wt
Tagcloud (Difference) ?			0mg 5months accumulated amphetamine caloric calorimetry consumption dark dioxide expenditure factoring hour indicative indirect influences ko littermates locomotor male modulates opioid psychostimulant respective sensitization striatum utilize weights wt
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