GNB5 and RGS9

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		GNB5	RGS9
Description		G protein subunit beta 5	regulator of G protein signaling 9
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Heterotrimeric G-protein Complex Plasma Membrane Membrane Dendrite Presynaptic Membrane Synapse Postsynaptic Membrane Cell Tip Parallel Fiber To Purkinje Cell Synapse Presynapse GTPase Activator Complex	Cytoplasm Plasma Membrane Membrane Presynaptic Membrane Neuron Projection Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding Signaling Receptor Complex Adaptor Activity G-protein Gamma-subunit Binding Protein-folding Chaperone Binding	GTPase Activity GTPase Activator Activity Protein Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway Light Adaption Positive Regulation Of GTPase Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Dark Adaptation	Response To Amphetamine G Protein-coupled Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway Nervous System Development Visual Perception Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Response To Estradiol Intracellular Signal Transduction Light Adaption Regulation Of Calcium Ion Export Across Plasma Membrane Dark Adaptation
Pathways		Activation of G protein gated Potassium channels G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	G alpha (i) signalling events G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs
Diseases			Bradyopsia
GWAS		Lewy body disease ( 25188341)	Adverse response to antithyroid drugs in Graves disease ( 30067105) Heel bone mineral density ( 28869591 30598549)
Interacting Genes		27 interacting genes: ANXA7 APP BNIP3L CDKN1A CSNK2B DRD2 E2F2 EIF3J GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNGT1 MCM2 MVD NR6A1 OLFM2 PSD PSMD4 RGS11 RGS6 RGS7 RGS9 RPA1 TSC22D1	6 interacting genes: ADRB2 DRD3 GNAT1 GNB5 GUCY2D RGS9BP
Entrez ID		10681	8787
HPRD ID		09191	04962
Ensembl ID		ENSG00000069966	ENSG00000108370
Uniprot IDs		O14775	A8K1G1 O75916
PDB IDs		7EWP 7EWR 8SG8 8SG9 8SGC 8SGL 8SH9 8SHA 8SHD 8SHE 8SHF 8SHG 8SHL 8SHN 8SHO 8SHP 8SHQ 8SHT
Enriched GO Terms of Interacting Partners?		G-protein Beta-subunit Binding Heterotrimeric G-protein Complex G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway GTPase Activity Signal Transduction G Protein-coupled Dopamine Receptor Signaling Pathway Plasma Membrane Synapse Response To Light Stimulus Neuron Projection Cellular Response To Catecholamine Stimulus Regulation Of Neurotransmitter Uptake Response To Catecholamine Dendrite Positive Regulation Of Long-term Synaptic Potentiation Molecular Function Activator Activity Protein Serine/threonine Kinase Binding Response To Radiation GTPase Activator Activity Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Receptor Internalization G-protein Alpha-subunit Binding	Regulation Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Response To Light Stimulus Response To Radiation Photoreceptor Outer Segment Membrane Regulation Of Opsin-mediated Signaling Pathway Response To Light Intensity System Process G Protein-coupled Dopamine Receptor Signaling Pathway Visual Perception Detection Of Light Stimulus Involved In Visual Perception Sensory Perception Of Light Stimulus Photoreceptor Disc Membrane Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Heterotrimeric G-protein Complex Nervous System Process Negative Regulation Of Blood Pressure Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Metal Ion Transport Detection Of Light Stimulus Visual Behavior Photoreceptor Outer Segment Signal Transduction Regulation Of Monoatomic Ion Transport Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity GTPase Activator Complex G-protein Gamma-subunit Binding Sensory Perception Beta2-adrenergic Receptor Activity Musculoskeletal Movement, Spinal Reflex Action Acyl Binding Cellular Response To Light Stimulus Background Adaptation Dark Adaptation Detection Of Abiotic Stimulus Regulation Of Signal Transduction Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Neural Tissue Regeneration Detection Of Stimulus Involved In Sensory Perception Light Adaption Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Psychosocial Stress Regulation Of Cell Communication Norepinephrine Binding Regulation Of Blood Pressure Positive Regulation Of Lipophagy
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