GNB5 and GNG13

Number of citations of the paper that reports this interaction (PMID 11675383)
9

Data Source:
HPRD (in vitro, in vivo)

		GNB5	GNG13
Gene Name		guanine nucleotide binding protein (G protein), beta 5	guanine nucleotide binding protein (G protein), gamma 13
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Plasma Membrane	Heterotrimeric G-protein Complex Plasma Membrane
	Molecular Function	GTPase Activity Signal Transducer Activity Protein Binding G-protein Gamma-subunit Binding Chaperone Binding	Signal Transducer Activity G-protein Beta-subunit Binding
	Biological Process	Signal Transduction Phototransduction, Visible Light Metabolic Process Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Negative Regulation Of Voltage-gated Calcium Channel Activity	Energy Reserve Metabolic Process Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Small Molecule Metabolic Process Sensory Perception Of Taste Cellular Response To Glucagon Stimulus
Pathways		G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Glucagon-type ligand receptors Signal amplification Signaling by Wnt G beta:gamma signalling through PLC beta Metabolic disorders of biological oxidation enzymes G beta:gamma signalling through PI3Kgamma Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (12/13) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Class B/2 (Secretin family receptors) ADP signalling through P2Y purinoceptor 12 Prostacyclin signalling through prostacyclin receptor G-protein beta:gamma signalling Vasopressin regulates renal water homeostasis via Aquaporins Opioid Signalling Regulation of insulin secretion Activation of Kainate Receptors upon glutamate binding GPCR ligand binding Aquaporin-mediated transport beta-catenin independent WNT signaling Adrenaline,noradrenaline inhibits insulin secretion Thrombin signalling through proteinase activated receptors (PARs) G alpha (q) signalling events Presynaptic function of Kainate receptors GPCR downstream signaling Platelet homeostasis Ca2+ pathway G-protein activation Platelet activation, signaling and aggregation Transmission across Chemical Synapses	Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes Peptide hormone metabolism Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Glucagon signaling in metabolic regulation ADP signalling through P2Y purinoceptor 12 G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification G beta:gamma signalling through PI3Kgamma G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Incretin synthesis, secretion, and inactivation Prostacyclin signalling through prostacyclin receptor Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Ca2+ pathway G-protein activation Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
Drugs
Diseases
GWAS
Protein-Protein Interactions		26 interactors: ANXA7 APP BNIP3L CDKN1A CSNK2B E2F2 EIF3J GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNGT1 MCM2 MVD NR6A1 OLFM2 PSD PSMD4 RGS11 RGS6 RGS7 RGS9 RPA1 TSC22D1	9 interactors: DLG1 DLG4 GNAT3 GNB1 GNB2 GNB3 GNB4 GNB5 LIN7B
Entrez ID		10681	51764
HPRD ID		09191	12116
Ensembl ID		ENSG00000069966	ENSG00000127588
Uniprot IDs		B3KWS4 O14775	Q9P2W3
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Glucagon Stimulus Response To Glucagon Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway Response To Hormone Cellular Response To Stimulus Signal Transduction Cellular Response To Hormone Stimulus Signaling Cell Communication Response To Stimulus Regulation Of Cellular Process Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Energy Derivation By Oxidation Of Organic Compounds Cell Surface Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Response To Organic Substance Generation Of Precursor Metabolites And Energy Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Signal Transduction Cellular Response To Organic Substance Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Response To Organonitrogen Compound G1/S Transition Of Mitotic Cell Cycle Synaptic Transmission Regulation Of Signaling Mitotic Cell Cycle Cellular Response To Light Stimulus Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Signal Transduction By P53 Class Mediator Regulation Of Metabolic Process Cell-cell Signaling Regulation Of Rhodopsin Mediated Signaling Pathway Positive Regulation Of Metabolic Process Response To Light Stimulus DNA Strand Elongation Involved In DNA Replication Cellular Process Cellular Response To Radiation Apoptotic Process DNA Strand Elongation Small Molecule Metabolic Process Rhodopsin Mediated Signaling Pathway	Cellular Response To Glucagon Stimulus Response To Glucagon Cell-cell Signaling Synaptic Transmission Establishment Or Maintenance Of Apical/basal Cell Polarity Energy Reserve Metabolic Process Maintenance Of Apical/basal Cell Polarity Signaling Receptor Localization To Synapse Energy Derivation By Oxidation Of Organic Compounds Cell Communication Cellular Response To Peptide Hormone Stimulus Detection Of Visible Light Cellular Response To Peptide Response To Organonitrogen Compound Detection Of Light Stimulus Maintenance Of Cell Polarity Generation Of Precursor Metabolites And Energy Response To Peptide Hormone Cellular Response To Organonitrogen Compound Protein Localization To Synapse Response To Peptide Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity G-protein Coupled Receptor Signaling Pathway Detection Of Abiotic Stimulus Establishment Or Maintenance Of Cell Polarity Regulation Of Rhodopsin Mediated Signaling Pathway Cortical Actin Cytoskeleton Organization Cellular Response To Hormone Stimulus Cortical Cytoskeleton Organization Rhodopsin Mediated Signaling Pathway Small Molecule Metabolic Process Receptor Clustering Nucleotide Phosphorylation Response To Light Stimulus Sensory Perception Of Taste Response To External Stimulus Response To Hormone Protein Localization To Membrane Phototransduction, Visible Light Regulation Of Ion Transmembrane Transport Response To Radiation Cellular Response To Light Stimulus Phototransduction Signal Transduction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Detection Of Stimulus Response To Organic Substance Cellular Response To Radiation Response To Stimulus
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