EIF3J and EIF3B

Number of citations of the paper that reports this interaction (PMID 18628297)
31

Data Source:
BioGRID (biochemical, affinity chromatography technology)
HPRD (in vivo)

		EIF3J	EIF3B
Gene Name		eukaryotic translation initiation factor 3, subunit J	eukaryotic translation initiation factor 3, subunit B
Image
Gene Ontology Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex	Nucleoplasm Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Extracellular Vesicular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m
	Molecular Function	Translation Initiation Factor Activity Protein Binding	Nucleotide Binding Translation Initiation Factor Activity Protein Binding Translation Initiation Factor Binding Protein Complex Scaffold
	Biological Process	Formation Of Translation Preinitiation Complex Cytoplasmic Translation Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process	Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process
Pathways		Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression	Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: CASP3 CSNK2A1 EIF3A EIF3B EIF3C EIF3D EIF3K GNB5 GOLM1 MAGED1 SIAH1 TADA3 TPD52L1	8 interactors: BRCA1 EIF3A EIF3G EIF3I EIF3J EIF4G1 IL2RB UPF1
Entrez ID		8669	8662
HPRD ID		04883	06795
Ensembl ID		ENSG00000104131	ENSG00000106263
Uniprot IDs		O75822	P55884
PDB IDs		2KRB 3BPJ	2KRB 2NLW
Enriched GO Terms of Interacting Partners?		Formation Of Translation Preinitiation Complex Regulation Of Translational Initiation Posttranscriptional Regulation Of Gene Expression Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Ribonucleoprotein Complex Assembly Translational Initiation Regulation Of Translation Formation Of Cytoplasmic Translation Initiation Complex Ribonucleoprotein Complex Biogenesis Cytoplasmic Translational Initiation Regulation Of Metabolic Process Cellular Macromolecular Complex Assembly Translation Cytoplasmic Translation Apoptotic Process Programmed Cell Death Cell Death Positive Regulation Of Apoptotic Signaling Pathway Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Gene Expression Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Neuron Apoptotic Process Protein Metabolic Process Neuron Death Cellular Protein Metabolic Process Regulation Of Apoptotic Process Regulation Of Cell Death Gene Expression Regulation Of Endopeptidase Activity Cellular Macromolecule Biosynthetic Process Regulation Of Peptidase Activity Macromolecule Biosynthetic Process Regulation Of Cellular Process Regulation Of Protein Phosphorylation Regulation Of Tubulin Deacetylation Cellular Component Assembly Regulation Of Protein Stability Negative Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Protein Metabolic Process Glial Cell Apoptotic Process Positive Regulation Of Signal Transduction Regulation Of Apoptotic DNA Fragmentation Regulation Of Phosphorylation Mature Ribosome Assembly Cell Cycle	Regulation Of Translational Initiation Formation Of Translation Preinitiation Complex Regulation Of Translation Posttranscriptional Regulation Of Gene Expression Translational Initiation Ribonucleoprotein Complex Assembly Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Translation Dosage Compensation By Inactivation Of X Chromosome Ribonucleoprotein Complex Biogenesis Dosage Compensation Cytoplasmic Translation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Macromolecular Complex Assembly Biosynthetic Process Regulation Of Gene Expression Cellular Component Assembly Gene Expression Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Positive Regulation Of Histone H3-K9 Acetylation Nuclear Export Cellular Protein Metabolic Process Cellular Response To Cytokine Stimulus Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Interleukin-2-mediated Signaling Pathway Response To Cytokine RNA Catabolic Process Formation Of Cytoplasmic Translation Initiation Complex Cellular Response To Indole-3-methanol Regulation Of Metabolic Process Negative Regulation Of Centriole Replication Regulation Of Gene Expression, Epigenetic Protein K6-linked Ubiquitination Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation Mature Ribosome Assembly Regulation Of Histone H3-K9 Acetylation Protein Metabolic Process Ribosomal Subunit Export From Nucleus Histone MRNA Catabolic Process Nucleocytoplasmic Transport Cytoplasmic Translational Initiation Nuclear Transport
Tagcloud ?		3a apart bindings binds carboxyl concurrently consisting docking eif3a eif3b eif3g eif3i exclusive exist indirectly mutually noncanonical participates perform purification solved spectrin subcomplex subcomplexes tandem translation translational tumorigenesis	attenuation b3 cardiovirulence coxsackievirus cvb3 decisive diagnomx diagnosticpathology eif4b eif4g eu extrapolating ires myocarditis neurovirulence organized p116 p220 p80 playing poliovirus reinforce ribosome sabin sabin3 slide u473 virtual www
Tagcloud (Difference) ?		3a apart bindings binds carboxyl concurrently consisting docking eif3a eif3g eif3i exclusive exist indirectly mutually noncanonical participates perform purification solved spectrin subcomplex subcomplexes tandem translation translational tumorigenesis	attenuation b3 cardiovirulence coxsackievirus cvb3 decisive diagnomx diagnosticpathology eif4b eif4g eu extrapolating ires myocarditis neurovirulence organized p116 p220 p80 playing poliovirus reinforce ribosome sabin sabin3 slide u473 virtual www
Tagcloud (Intersection) ?		eif3b