GNB5 and RGS11

Number of citations of the paper that reports this interaction (PMID 9315921)
79

Data Source:
HPRD (in vivo, in vitro)

		GNB5	RGS11
Gene Name		guanine nucleotide binding protein (G protein), beta 5	regulator of G-protein signaling 11
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Plasma Membrane	Cytoplasm Heterotrimeric G-protein Complex Plasma Membrane Protein Complex Dendrite Terminus
	Molecular Function	GTPase Activity Signal Transducer Activity Protein Binding G-protein Gamma-subunit Binding Chaperone Binding	Signal Transducer Activity GTPase Activator Activity G-protein Beta-subunit Binding
	Biological Process	Signal Transduction Phototransduction, Visible Light Metabolic Process Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Negative Regulation Of Voltage-gated Calcium Channel Activity	G-protein Coupled Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Intracellular Signal Transduction Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity
Pathways		G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Glucagon-type ligand receptors Signal amplification Signaling by Wnt G beta:gamma signalling through PLC beta Metabolic disorders of biological oxidation enzymes G beta:gamma signalling through PI3Kgamma Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (12/13) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Class B/2 (Secretin family receptors) ADP signalling through P2Y purinoceptor 12 Prostacyclin signalling through prostacyclin receptor G-protein beta:gamma signalling Vasopressin regulates renal water homeostasis via Aquaporins Opioid Signalling Regulation of insulin secretion Activation of Kainate Receptors upon glutamate binding GPCR ligand binding Aquaporin-mediated transport beta-catenin independent WNT signaling Adrenaline,noradrenaline inhibits insulin secretion Thrombin signalling through proteinase activated receptors (PARs) G alpha (q) signalling events Presynaptic function of Kainate receptors GPCR downstream signaling Platelet homeostasis Ca2+ pathway G-protein activation Platelet activation, signaling and aggregation Transmission across Chemical Synapses	Signaling by GPCR GPCR downstream signaling G alpha (i) signalling events
Drugs
Diseases
GWAS			Mean corpuscular hemoglobin ( 20139978)
Protein-Protein Interactions		26 interactors: ANXA7 APP BNIP3L CDKN1A CSNK2B E2F2 EIF3J GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNGT1 MCM2 MVD NR6A1 OLFM2 PSD PSMD4 RGS11 RGS6 RGS7 RGS9 RPA1 TSC22D1	2 interactors: ADRB2 GNB5
Entrez ID		10681	8786
HPRD ID		09191	04872
Ensembl ID		ENSG00000069966	ENSG00000076344
Uniprot IDs		B3KWS4 O14775	B7Z285 O94810 Q4TT70
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Glucagon Stimulus Response To Glucagon Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway Response To Hormone Cellular Response To Stimulus Signal Transduction Cellular Response To Hormone Stimulus Signaling Cell Communication Response To Stimulus Regulation Of Cellular Process Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Energy Derivation By Oxidation Of Organic Compounds Cell Surface Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Response To Organic Substance Generation Of Precursor Metabolites And Energy Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Signal Transduction Cellular Response To Organic Substance Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Response To Organonitrogen Compound G1/S Transition Of Mitotic Cell Cycle Synaptic Transmission Regulation Of Signaling Mitotic Cell Cycle Cellular Response To Light Stimulus Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Signal Transduction By P53 Class Mediator Regulation Of Metabolic Process Cell-cell Signaling Regulation Of Rhodopsin Mediated Signaling Pathway Positive Regulation Of Metabolic Process Response To Light Stimulus DNA Strand Elongation Involved In DNA Replication Cellular Process Cellular Response To Radiation Apoptotic Process DNA Strand Elongation Small Molecule Metabolic Process Rhodopsin Mediated Signaling Pathway	Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Vasodilation By Norepinephrine-epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Voltage-gated Calcium Channel Activity Heat Generation Diet Induced Thermogenesis Regulation Of Ion Transport Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Negative Regulation Of Smooth Muscle Contraction Adrenergic Receptor Signaling Pathway Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Response To Dietary Excess Negative Regulation Of Cation Channel Activity Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Multicellular Organism Growth Negative Regulation Of Muscle Contraction Negative Regulation Of Systemic Arterial Blood Pressure Temperature Homeostasis Regulation Of Rhodopsin Mediated Signaling Pathway Response To Abiotic Stimulus Activation Of Adenylate Cyclase Activity G-protein Coupled Receptor Signaling Pathway Endosome To Lysosome Transport Rhodopsin Mediated Signaling Pathway Vasodilation Bone Resorption Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Bone Mineralization Negative Regulation Of Transporter Activity Negative Regulation Of Calcium Ion Transport Positive Regulation Of Biomineral Tissue Development Brown Fat Cell Differentiation Lysosomal Transport Regulation Of Vasodilation Positive Regulation Of Lyase Activity Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Blood Pressure Regulation Of Smooth Muscle Contraction Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Transmembrane Transport Negative Regulation Of Protein Binding Regulation Of Adenylate Cyclase Activity Response To Cold Bone Remodeling Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of CAMP Biosynthetic Process Regulation Of Cyclase Activity Regulation Of Sodium Ion Transport
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