EIF3J and TADA3

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EIF3J	TADA3
Gene Name		eukaryotic translation initiation factor 3, subunit J	transcriptional adaptor 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex	Intracellular Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex STAGA Complex Transcription Factor TFTC Complex Mitotic Spindle
	Molecular Function	Translation Initiation Factor Activity Protein Binding	Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Ligand-dependent Nuclear Receptor Binding Protein Domain Specific Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity
	Biological Process	Formation Of Translation Preinitiation Complex Cytoplasmic Translation Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process	Regulation Of Protein Phosphorylation Chromatin Organization Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Nuclear Division Positive Regulation Of Gene Expression Intracellular Estrogen Receptor Signaling Pathway Regulation Of Histone Deacetylation Regulation Of Protein Stability Histone H3 Acetylation Positive Regulation Of Transcription, DNA-templated Regulation Of Tubulin Deacetylation
Pathways		Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression	Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: CASP3 CSNK2A1 EIF3A EIF3B EIF3C EIF3D EIF3K GNB5 GOLM1 MAGED1 SIAH1 TADA3 TPD52L1	27 interactors: ADPGK ANKRD12 AR CCDC101 CCNC EIF3J EP300 ESR1 FAM107B HEXIM2 HIST3H3 HSPA8 ING5 KDM1A MAGEH1 NR1I2 PIAS4 RARA RFX1 RXRA SAP18 TADA2A TP53 TXNRD2 USP5 XRCC6 ZNF7
Entrez ID		8669	10474
HPRD ID		04883	04252
Ensembl ID		ENSG00000104131	ENSG00000171148
Uniprot IDs		O75822	A8K899 O75528
PDB IDs		2KRB 3BPJ
Enriched GO Terms of Interacting Partners?		Formation Of Translation Preinitiation Complex Regulation Of Translational Initiation Posttranscriptional Regulation Of Gene Expression Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Ribonucleoprotein Complex Assembly Translational Initiation Regulation Of Translation Formation Of Cytoplasmic Translation Initiation Complex Ribonucleoprotein Complex Biogenesis Cytoplasmic Translational Initiation Regulation Of Metabolic Process Cellular Macromolecular Complex Assembly Translation Cytoplasmic Translation Apoptotic Process Programmed Cell Death Cell Death Positive Regulation Of Apoptotic Signaling Pathway Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Gene Expression Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Neuron Apoptotic Process Protein Metabolic Process Neuron Death Cellular Protein Metabolic Process Regulation Of Apoptotic Process Regulation Of Cell Death Gene Expression Regulation Of Endopeptidase Activity Cellular Macromolecule Biosynthetic Process Regulation Of Peptidase Activity Macromolecule Biosynthetic Process Regulation Of Cellular Process Regulation Of Protein Phosphorylation Regulation Of Tubulin Deacetylation Cellular Component Assembly Regulation Of Protein Stability Negative Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Protein Metabolic Process Glial Cell Apoptotic Process Positive Regulation Of Signal Transduction Regulation Of Apoptotic DNA Fragmentation Regulation Of Phosphorylation Mature Ribosome Assembly Cell Cycle	Transcription, DNA-templated RNA Biosynthetic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Nitrogen Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Steroid Hormone Mediated Signaling Pathway Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Hormone-mediated Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Chromatin Organization Prostate Gland Development Cellular Response To Steroid Hormone Stimulus Cellular Metabolic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Histone Acetylation Regulation Of Protein Metabolic Process Peptidyl-lysine Modification Internal Peptidyl-lysine Acetylation Response To Steroid Hormone
Tagcloud ?		3a apart bindings binds carboxyl concurrently consisting docking eif3a eif3b eif3g eif3i exclusive exist indirectly mutually noncanonical participates perform purification solved spectrin subcomplex subcomplexes tandem translation translational tumorigenesis	3p anomalies arm camk1 congenital creld1 define deleted deletion deletions features give handicap interstitial involve kb lengths mb mtmr14 overlap presents prove respect rise seizures srgap3 syndrome terminus typical
Tagcloud (Difference) ?		3a apart bindings binds carboxyl concurrently consisting docking eif3a eif3b eif3g eif3i exclusive exist indirectly mutually noncanonical participates perform purification solved spectrin subcomplex subcomplexes tandem translation translational tumorigenesis	3p anomalies arm camk1 congenital creld1 define deleted deletion deletions features give handicap interstitial involve kb lengths mb mtmr14 overlap presents prove respect rise seizures srgap3 syndrome terminus typical
Tagcloud (Intersection) ?