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EIF3C and PFDN1
Number of citations of the paper that reports this interaction (PMID
21900206
)
27
Data Source:
BioGRID
(two hybrid)
EIF3C
PFDN1
Gene Name
eukaryotic translation initiation factor 3, subunit C
prefoldin subunit 1
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytosol
Eukaryotic Translation Initiation Factor 3 Complex
Eukaryotic 43S Preinitiation Complex
Eukaryotic 48S Preinitiation Complex
Prefoldin Complex
Molecular Function
Translation Initiation Factor Activity
Protein Binding
Translation Initiation Factor Binding
Poly(A) RNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Unfolded Protein Binding
Biological Process
Formation Of Translation Preinitiation Complex
Translation
Translational Initiation
Regulation Of Translational Initiation
Gene Expression
Cellular Protein Metabolic Process
Regulation Of Transcription, DNA-templated
Protein Folding
Cell Cycle
Telencephalon Development
Cerebellum Development
Actin Cytoskeleton Organization
B Cell Activation
Cellular Protein Metabolic Process
'de Novo' Posttranslational Protein Folding
Pathways
Ribosomal scanning and start codon recognition
Translation initiation complex formation
Formation of the ternary complex, and subsequently, the 43S complex
GTP hydrolysis and joining of the 60S ribosomal subunit
Translation
Eukaryotic Translation Initiation
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Formation of a pool of free 40S subunits
Cap-dependent Translation Initiation
L13a-mediated translational silencing of Ceruloplasmin expression
Protein folding
Prefoldin mediated transfer of substrate to CCT/TriC
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Chaperonin-mediated protein folding
Drugs
Diseases
GWAS
Crohn's disease (
21102463
)
Inflammatory bowel disease (
23128233
)
Inflammatory bowel disease (early onset) (
19915574
)
Protein-Protein Interactions
15 interactors:
AAGAB
CALM1
EIF1AX
EIF3E
EIF3G
EIF3J
EIF3K
HMOX2
MAPK6
NDUFA4L2
PFDN1
RPS6KA3
SMAD9
SNIP1
UBC
54 interactors:
ACTA1
ACTB
ALB
ASNA1
BRK1
CCDC85A
CHGA
DCTN1
DEFA1
DGCR14
EDRF1
EIF3C
EIF4A2
EOMES
EXT2
EZH2
FAM20C
GIT1
GPRASP1
HAP1
HIP1
HMGXB3
HOXD8
IFT140
IMMT
INPP5K
JADE1
KIAA0408
KIAA1377
LRIF1
MED31
NDC80
NR2F1
PDE4DIP
PDHB
PFDN2
PLXNB2
PRKD2
PSME1
PTN
RMI1
RPLP1
RPS28
SEC31A
SKP2
SNX5
SPTBN4
SUMO3
SYNDIG1
TERT
TTC38
TUBA1A
YEATS4
ZNF235
Entrez ID
8663
5201
HPRD ID
04889
05357
Ensembl ID
ENSG00000184110
ENSG00000113068
Uniprot IDs
H3BRV0
Q99613
O60925
PDB IDs
Enriched GO Terms of Interacting Partners
?
Formation Of Translation Preinitiation Complex
Regulation Of Translational Initiation
Translational Initiation
Posttranscriptional Regulation Of Gene Expression
Regulation Of Translation
Ribonucleoprotein Complex Assembly
Cellular Protein Metabolic Process
Translation
Ribonucleoprotein Complex Biogenesis
Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Metabolic Process
Cellular Metabolic Process
Protein Metabolic Process
Neurotrophin TRK Receptor Signaling Pathway
Gene Expression
Neurotrophin Signaling Pathway
Cellular Response To Growth Factor Stimulus
MAPK Cascade
Response To Growth Factor
Intracellular Signal Transduction
Cellular Macromolecular Complex Assembly
Toll-like Receptor 5 Signaling Pathway
Regulation Of Gene Expression
Toll-like Receptor 10 Signaling Pathway
Regulation Of DNA-templated Transcription In Response To Stress
I-kappaB Kinase/NF-kappaB Signaling
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Signal Transduction By Phosphorylation
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Glycogen Metabolic Process
Response To Hypoxia
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Negative Regulation Of Cellular Protein Metabolic Process
Toll-like Receptor 4 Signaling Pathway
Polysaccharide Metabolic Process
Midbrain Development
Negative Regulation Of Protein Metabolic Process
Enzyme Linked Receptor Protein Signaling Pathway
Heme Oxidation
Toll-like Receptor Signaling Pathway
Central Nervous System Development
Stress-activated MAPK Cascade
Cellular Macromolecule Biosynthetic Process
Stress-activated Protein Kinase Signaling Cascade
Immune Response-regulating Signaling Pathway
Organelle Organization
Cellular Localization
Cellular Macromolecule Biosynthetic Process
Cellular Component Assembly
Macromolecule Biosynthetic Process
Gene Expression
Membrane Organization
RNA Biosynthetic Process
Cellular Protein Localization
Establishment Of Protein Localization To Membrane
Protein Localization
Developmental Process
Cerebral Cortex Regionalization
Mitotic Cell Cycle
Biosynthetic Process
Cellular Process
Cytoskeleton-dependent Intracellular Transport
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle G1/S Phase Transition
Cellular Metabolic Process
Establishment Of Localization In Cell
Anatomical Structure Development
RNA Metabolic Process
Organelle Localization
'de Novo' Posttranslational Protein Folding
Intracellular Transport
Cell Cycle Process
'de Novo' Protein Folding
Regulation Of Metabolic Process
Telencephalon Regionalization
Regulation Of Protein Metabolic Process
Mitotic Cell Cycle Process
Regulation Of Cellular Component Organization
Regulation Of Cellular Protein Metabolic Process
Protein Localization To Organelle
Positive Regulation Of Cellular Metabolic Process
Protein Localization To Membrane
Vesicle Localization
Regulation Of Cilium Assembly
Multicellular Organismal Development
Regulation Of Cellular Process
Regulation Of Mitotic Cell Cycle Phase Transition
Anatomical Structure Morphogenesis
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Killing Of Cells Of Other Organism
Regulation Of Peptidyl-serine Phosphorylation
Positive Regulation Of Metabolic Process
Regulation Of Cell Cycle Phase Transition
Anatomical Structure Formation Involved In Morphogenesis
Tagcloud
?
adr
alternatively
b16f10
deliver
emphasize
eukaryote
eventually
evolving
g0
gep
hct116
housekeeping
hyaluronan
kind
lnps
manipulating
mcf7
nar
nci
polysome
res
retrieved
rnai
run
seeking
sirnas
ubiquitously
unstable
vital
Tagcloud (Difference)
?
adr
alternatively
b16f10
deliver
emphasize
eukaryote
eventually
evolving
g0
gep
hct116
housekeeping
hyaluronan
kind
lnps
manipulating
mcf7
nar
nci
polysome
res
retrieved
rnai
run
seeking
sirnas
ubiquitously
unstable
vital
Tagcloud (Intersection)
?