EIF3C and TACC3

Number of citations of the paper that reports this interaction (PubMedID 30217970)
38

Data Source:
BioGRID (two hybrid)

		EIF3C	TACC3
Description		eukaryotic translation initiation factor 3 subunit C	transforming acidic coiled-coil containing protein 3
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GO Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex	Spindle Pole Cytoplasm Golgi Apparatus Centrosome Spindle Cytosol Cytoskeleton Centriolar Satellite Ciliary Basal Body Mitotic Spindle
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding Translation Initiation Factor Binding Ribosome Binding	Protein Binding
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Translational Initiation Positive Regulation Of Translation	Microtubule Cytoskeleton Organization Mitotic Spindle Organization Metaphase/anaphase Transition Of Mitotic Cell Cycle Nuclear Migration Cerebral Cortex Development Cell Division Regulation Of Mitotic Spindle Organization Microtubule Cytoskeleton Organization Involved In Mitosis
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	NOTCH3 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 21102463 28067908) Extremely high intelligence ( 29520040) Inflammatory bowel disease ( 23128233 28067908) Inflammatory bowel disease (early onset) ( 19915574) Lamb consumption ( 32066663)	Appendicular lean mass ( 33097823) Bladder cancer ( 20972438 24163127) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Hip circumference adjusted for BMI ( 34021172) Mean spheric corpuscular volume ( 32888494) Subcortical volume (MOSTest) ( 32665545) Urinary bladder cancer ( 20348956)
Interacting Genes		23 interacting genes: AAGAB ALKBH4 BTG3 CALM1 COXFA4L2 DSCAM EIF1AX EIF3E EIF3G EIF3J EIF3K ERCC6 HMOX2 MAPK6 PFDN1 PLEKHF2 RNF10 RPS6KA3 SMAD9 SNCA SNIP1 TACC3 TRAPPC2	30 interacting genes: AKAP9 ARHGDIG ARNT ARNT2 ASPSCR1 AURKA BEX2 BEX3 CATSPERT CCHCR1 CDC20B CDKL5 CIB3 CLIP4 DRC10 EIF3C GDF15 KAT2A KIZ KLC1 KLHL38 NDEL1 NOD2 NUP54 RNF20 SNX20 SPATA18 TBC1D22B TTF2 VPS37C
Entrez ID		8663	10460
HPRD ID		04889	05601
Ensembl ID		ENSG00000184110	ENSG00000013810
Uniprot IDs		Q99613	A0A087WUE2 Q9Y6A5
PDB IDs		3J8B 3J8C 6YBD 6YBW 6ZMW 6ZON 6ZP4 7A09 7QP6 7QP7 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPL 8RG0 8XXN 9BLN	5LXN 5LXO 5ODS 5ODT
Enriched GO Terms of Interacting Partners?		Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Translation Initiation Factor Activity Translational Initiation Cytoplasmic Translational Initiation Protein-RNA Complex Assembly Regulation Of Acyl-CoA Biosynthetic Process Translation Vesicle-mediated Transport In Synapse Positive Regulation Of Vesicle Fusion	Cytoplasm Aryl Hydrocarbon Receptor Binding Aryl Hydrocarbon Receptor Complex Microtubule-based Process Mitotic Centrosome Separation Centrosome Localization Axon Hillock Centrosome Separation
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