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EIF3C
Gene Name
eukaryotic translation initiation factor 3, subunit C
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytosol
Eukaryotic Translation Initiation Factor 3 Complex
Eukaryotic 43S Preinitiation Complex
Eukaryotic 48S Preinitiation Complex
Molecular Function
Translation Initiation Factor Activity
Protein Binding
Translation Initiation Factor Binding
Poly(A) RNA Binding
Biological Process
Formation Of Translation Preinitiation Complex
Translation
Translational Initiation
Regulation Of Translational Initiation
Gene Expression
Cellular Protein Metabolic Process
Pathways
Ribosomal scanning and start codon recognition
Translation initiation complex formation
Formation of the ternary complex, and subsequently, the 43S complex
GTP hydrolysis and joining of the 60S ribosomal subunit
Translation
Eukaryotic Translation Initiation
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Formation of a pool of free 40S subunits
Cap-dependent Translation Initiation
L13a-mediated translational silencing of Ceruloplasmin expression
Drugs
Diseases
GWAS
Crohn's disease (
21102463
)
Inflammatory bowel disease (
23128233
)
Inflammatory bowel disease (early onset) (
19915574
)
Protein-protein Interactions
15 interactors:
AAGAB
CALM1
EIF1AX
EIF3E
EIF3G
EIF3J
EIF3K
HMOX2
MAPK6
NDUFA4L2
PFDN1
RPS6KA3
SMAD9
SNIP1
UBC
Entrez ID
8663
HPRD ID
04889
Ensembl ID
ENSG00000184110
Uniprot IDs
H3BRV0
Q99613
PDB IDs
Enriched GO Terms of Interacting Partners
?
Formation Of Translation Preinitiation Complex
Regulation Of Translational Initiation
Translational Initiation
Posttranscriptional Regulation Of Gene Expression
Regulation Of Translation
Ribonucleoprotein Complex Assembly
Cellular Protein Metabolic Process
Translation
Ribonucleoprotein Complex Biogenesis
Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Metabolic Process
Cellular Metabolic Process
Protein Metabolic Process
Neurotrophin TRK Receptor Signaling Pathway
Gene Expression
Neurotrophin Signaling Pathway
Cellular Response To Growth Factor Stimulus
MAPK Cascade
Response To Growth Factor
Intracellular Signal Transduction
Cellular Macromolecular Complex Assembly
Toll-like Receptor 5 Signaling Pathway
Regulation Of Gene Expression
Toll-like Receptor 10 Signaling Pathway
Regulation Of DNA-templated Transcription In Response To Stress
I-kappaB Kinase/NF-kappaB Signaling
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Signal Transduction By Phosphorylation
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Glycogen Metabolic Process
Response To Hypoxia
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Negative Regulation Of Cellular Protein Metabolic Process
Toll-like Receptor 4 Signaling Pathway
Polysaccharide Metabolic Process
Midbrain Development
Negative Regulation Of Protein Metabolic Process
Enzyme Linked Receptor Protein Signaling Pathway
Heme Oxidation
Toll-like Receptor Signaling Pathway
Central Nervous System Development
Stress-activated MAPK Cascade
Cellular Macromolecule Biosynthetic Process
Stress-activated Protein Kinase Signaling Cascade
Immune Response-regulating Signaling Pathway
Tagcloud
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adr
alternatively
b16f10
deliver
emphasize
eukaryote
eventually
evolving
g0
gep
hct116
housekeeping
hyaluronan
kind
lnps
manipulating
mcf7
nar
nci
polysome
res
retrieved
rnai
run
seeking
sirnas
ubiquitously
unstable
vital