EIF3C and AAGAB

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EIF3C	AAGAB
Gene Name		eukaryotic translation initiation factor 3, subunit C	alpha- and gamma-adaptin binding protein
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Translation Initiation Factor Activity Protein Binding Translation Initiation Factor Binding Poly(A) RNA Binding
	Biological Process	Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process	Protein Transport
Pathways		Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression
Drugs
Diseases
GWAS		Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233) Inflammatory bowel disease (early onset) ( 19915574)
Protein-Protein Interactions		15 interactors: AAGAB CALM1 EIF1AX EIF3E EIF3G EIF3J EIF3K HMOX2 MAPK6 NDUFA4L2 PFDN1 RPS6KA3 SMAD9 SNIP1 UBC	5 interactors: AP1S3 AP2S1 EIF3C HEATR1 UNC119
Entrez ID		8663	79719
HPRD ID		04889	07754
Ensembl ID		ENSG00000184110	ENSG00000103591
Uniprot IDs		H3BRV0 Q99613	B4DG44 Q6PD74
PDB IDs
Enriched GO Terms of Interacting Partners?		Formation Of Translation Preinitiation Complex Regulation Of Translational Initiation Translational Initiation Posttranscriptional Regulation Of Gene Expression Regulation Of Translation Ribonucleoprotein Complex Assembly Cellular Protein Metabolic Process Translation Ribonucleoprotein Complex Biogenesis Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Metabolic Process Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Gene Expression Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus MAPK Cascade Response To Growth Factor Intracellular Signal Transduction Cellular Macromolecular Complex Assembly Toll-like Receptor 5 Signaling Pathway Regulation Of Gene Expression Toll-like Receptor 10 Signaling Pathway Regulation Of DNA-templated Transcription In Response To Stress I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Signal Transduction By Phosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Glycogen Metabolic Process Response To Hypoxia TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Polysaccharide Metabolic Process Midbrain Development Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Heme Oxidation Toll-like Receptor Signaling Pathway Central Nervous System Development Stress-activated MAPK Cascade Cellular Macromolecule Biosynthetic Process Stress-activated Protein Kinase Signaling Cascade Immune Response-regulating Signaling Pathway	Regulation Of Defense Response To Virus By Virus Regulation Of Defense Response To Virus Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Negative Regulation Of Clathrin-mediated Endocytosis Negative Regulation Of Caveolin-mediated Endocytosis Cytokinesis, Completion Of Separation Regulation Of Endocytosis Antigen Processing And Presentation Of Peptide Antigen Regulation Of Caveolin-mediated Endocytosis Antigen Processing And Presentation Mitotic Cytokinetic Process Ribonucleoprotein Complex Biogenesis Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Positive Regulation Of Transcription From RNA Polymerase I Promoter Regulation Of Vesicle-mediated Transport Regulation Of Clathrin-mediated Endocytosis Cell Separation After Cytokinesis Negative Regulation Of Receptor-mediated Endocytosis Lipoprotein Transport Regulation Of Transcription From RNA Polymerase I Promoter Formation Of Translation Preinitiation Complex Protein Localization Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Viral Process Synaptic Transmission Maturation Of SSU-rRNA Cellular Macromolecular Complex Assembly Endocytosis Clathrin Coat Assembly Positive Regulation Of Protein Tyrosine Kinase Activity Clathrin-mediated Endocytosis Ribosomal Small Subunit Biogenesis Mitotic Cytokinesis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Endocytosis Negative Regulation Of ERBB Signaling Pathway Membrane Organization Regulation Of Protein Tyrosine Kinase Activity Intracellular Protein Transport Cell-cell Signaling
Tagcloud ?		adr alternatively b16f10 deliver emphasize eukaryote eventually evolving g0 gep hct116 housekeeping hyaluronan kind lnps manipulating mcf7 nar nci polysome res retrieved rnai run seeking sirnas ubiquitously unstable vital
Tagcloud (Difference) ?		adr alternatively b16f10 deliver emphasize eukaryote eventually evolving g0 gep hct116 housekeeping hyaluronan kind lnps manipulating mcf7 nar nci polysome res retrieved rnai run seeking sirnas ubiquitously unstable vital
Tagcloud (Intersection) ?