EIF3C and RPS6KA3

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		EIF3C	RPS6KA3
Description		eukaryotic translation initiation factor 3 subunit C	ribosomal protein S6 kinase A3
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GO Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Synapse
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding Translation Initiation Factor Binding Ribosome Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Translational Initiation Positive Regulation Of Translation	Skeletal System Development Toll-like Receptor Signaling Pathway Signal Transduction Chemical Synaptic Transmission Central Nervous System Development Positive Regulation Of Cell Growth Response To Lipopolysaccharide Intracellular Signal Transduction TORC1 Signaling Negative Regulation Of Apoptotic Process Regulation Of Translation In Response To Stress Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK
Drugs			Acetylsalicylic acid Fostamatinib
Diseases			Non-syndromic X-linked mental retardation Coffin-Lowry syndrome (CLS)
GWAS		Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 21102463 28067908) Extremely high intelligence ( 29520040) Inflammatory bowel disease ( 23128233 28067908) Inflammatory bowel disease (early onset) ( 19915574) Lamb consumption ( 32066663)	Refractive error ( 32231278)
Interacting Genes		23 interacting genes: AAGAB ALKBH4 BTG3 CALM1 COXFA4L2 DSCAM EIF1AX EIF3E EIF3G EIF3J EIF3K ERCC6 HMOX2 MAPK6 PFDN1 PLEKHF2 RNF10 RPS6KA3 SMAD9 SNCA SNIP1 TACC3 TRAPPC2	44 interacting genes: ATM ATP5PF BAD BARX1 CREB1 CREBBP CTNND1 EIF3C ESR1 FBXO7 FGF2 FGFR3 FYN GRIN1 GRIN2D H2AX H3-4 H3C1 HMGN1 HMGN2 HTR2A ILKAP KRT18 MAGI1 MAPK1 MAPK3 MAPT MASP1 MLST8 MTOR NEDD4 NFKBIA NR4A1 PDPK1 PEA15 RPTOR SHANK1 SMS SRC STAT3 STK11 SUMO2 TP53 YBX1
Entrez ID		8663	6197
HPRD ID		04889	02092
Ensembl ID		ENSG00000184110	ENSG00000177189
Uniprot IDs		Q99613	A0A384MDW3 B1AXG1 B4DG22 B7ZB17 P51812
PDB IDs		3J8B 3J8C 6YBD 6YBW 6ZMW 6ZON 6ZP4 7A09 7QP6 7QP7 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPL 8RG0 8XXN 9BLN	4D9T 4D9U 4JG6 4JG7 4JG8 4NUS 4NW5 4NW6 5D9K 5D9L 7OPO 8EQ5 8R58 8XEY 8XFY
Enriched GO Terms of Interacting Partners?		Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Translation Initiation Factor Activity Translational Initiation Cytoplasmic Translational Initiation Protein-RNA Complex Assembly Regulation Of Acyl-CoA Biosynthetic Process Translation Vesicle-mediated Transport In Synapse Positive Regulation Of Vesicle Fusion	Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Autophagy Regulation Of Carbohydrate Catabolic Process Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Developmental Process Regulation Of Pentose-phosphate Shunt Positive Regulation Of ATP Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Catabolic Process Regulation Of Purine Nucleotide Metabolic Process Intracellular Signaling Cassette Regulation Of NADP Metabolic Process Positive Regulation Of Glycolytic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Glycolytic Process DNA Damage Response Positive Regulation Of Phosphate Metabolic Process Anatomical Structure Morphogenesis Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Biological Quality Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Regulation Of Protein Stability Regulation Of Immune System Process Negative Regulation Of Signal Transduction Regulation Of ATP Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Cellular Response To Heat Protein Localization To Organelle Regulation Of Cell Population Proliferation Positive Regulation Of Pentose-phosphate Shunt Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Primary Metabolic Process Response To Stress Regulation Of TOR Signaling Regulation Of Small Molecule Metabolic Process Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Immune System Process Negative Regulation Of Apoptotic Process
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