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EIF3C and HMOX2
Number of citations of the paper that reports this interaction (PMID
21900206
)
27
Data Source:
BioGRID
(two hybrid)
EIF3C
HMOX2
Gene Name
eukaryotic translation initiation factor 3, subunit C
heme oxygenase (decycling) 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytosol
Eukaryotic Translation Initiation Factor 3 Complex
Eukaryotic 43S Preinitiation Complex
Eukaryotic 48S Preinitiation Complex
Endoplasmic Reticulum Membrane
Plasma Membrane
Membrane
Molecular Function
Translation Initiation Factor Activity
Protein Binding
Translation Initiation Factor Binding
Poly(A) RNA Binding
Heme Oxygenase (decyclizing) Activity
Protein Binding
Metal Ion Binding
Biological Process
Formation Of Translation Preinitiation Complex
Translation
Translational Initiation
Regulation Of Translational Initiation
Gene Expression
Cellular Protein Metabolic Process
Response To Hypoxia
Porphyrin-containing Compound Metabolic Process
Heme Oxidation
Cellular Iron Ion Homeostasis
Heme Catabolic Process
Small Molecule Metabolic Process
Transmembrane Transport
Pathways
Ribosomal scanning and start codon recognition
Translation initiation complex formation
Formation of the ternary complex, and subsequently, the 43S complex
GTP hydrolysis and joining of the 60S ribosomal subunit
Translation
Eukaryotic Translation Initiation
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Formation of a pool of free 40S subunits
Cap-dependent Translation Initiation
L13a-mediated translational silencing of Ceruloplasmin expression
Iron uptake and transport
Metabolism of porphyrins
Heme degradation
Drugs
NADH
Diseases
GWAS
Crohn's disease (
21102463
)
Inflammatory bowel disease (
23128233
)
Inflammatory bowel disease (early onset) (
19915574
)
Protein-Protein Interactions
15 interactors:
AAGAB
CALM1
EIF1AX
EIF3E
EIF3G
EIF3J
EIF3K
HMOX2
MAPK6
NDUFA4L2
PFDN1
RPS6KA3
SMAD9
SNIP1
UBC
32 interactors:
A2M
APP
ATP5B
BLOC1S2
CEBPZ
COPS6
CSNK2A1
EEF1G
EIF3C
GIT1
GPRASP1
HAP1
IMMT
INPP5K
ITFG1
JADE1
KCNMA1
KIAA1377
LRIF1
MED31
NDUFS2
NKRF
NR3C1
PLXNB2
RBBP4
SETDB1
SHC1
SKA2
SNX5
SNX7
ZFP28
ZNF746
Entrez ID
8663
3163
HPRD ID
04889
00783
Ensembl ID
ENSG00000184110
ENSG00000103415
Uniprot IDs
H3BRV0
Q99613
I3L430
P30519
PDB IDs
2Q32
2QPP
2RGZ
Enriched GO Terms of Interacting Partners
?
Formation Of Translation Preinitiation Complex
Regulation Of Translational Initiation
Translational Initiation
Posttranscriptional Regulation Of Gene Expression
Regulation Of Translation
Ribonucleoprotein Complex Assembly
Cellular Protein Metabolic Process
Translation
Ribonucleoprotein Complex Biogenesis
Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Metabolic Process
Cellular Metabolic Process
Protein Metabolic Process
Neurotrophin TRK Receptor Signaling Pathway
Gene Expression
Neurotrophin Signaling Pathway
Cellular Response To Growth Factor Stimulus
MAPK Cascade
Response To Growth Factor
Intracellular Signal Transduction
Cellular Macromolecular Complex Assembly
Toll-like Receptor 5 Signaling Pathway
Regulation Of Gene Expression
Toll-like Receptor 10 Signaling Pathway
Regulation Of DNA-templated Transcription In Response To Stress
I-kappaB Kinase/NF-kappaB Signaling
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Signal Transduction By Phosphorylation
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Glycogen Metabolic Process
Response To Hypoxia
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Negative Regulation Of Cellular Protein Metabolic Process
Toll-like Receptor 4 Signaling Pathway
Polysaccharide Metabolic Process
Midbrain Development
Negative Regulation Of Protein Metabolic Process
Enzyme Linked Receptor Protein Signaling Pathway
Heme Oxidation
Toll-like Receptor Signaling Pathway
Central Nervous System Development
Stress-activated MAPK Cascade
Cellular Macromolecule Biosynthetic Process
Stress-activated Protein Kinase Signaling Cascade
Immune Response-regulating Signaling Pathway
Gene Expression
Transcription, DNA-templated
RNA Biosynthetic Process
Axon Cargo Transport
Cellular Macromolecule Biosynthetic Process
Organelle Organization
Macromolecule Biosynthetic Process
RNA Metabolic Process
Biosynthetic Process
Regulation Of Transcription, DNA-templated
Cellular Process
Regulation Of Gene Expression
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of ERBB Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Nucleobase-containing Compound Metabolic Process
Regulation Of Cell Cycle Phase Transition
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Cell Cycle Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Receptor Activity
Cell Projection Organization
Cellular Nitrogen Compound Metabolic Process
Anterograde Axon Cargo Transport
Microtubule-based Transport
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Epidermal Growth Factor-activated Receptor Activity
Regulation Of Body Fluid Levels
Cytoskeleton-dependent Intracellular Transport
Regulation Of Cell Cycle
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Neurotrophin Production
Positive Regulation Of Nonmotile Primary Cilium Assembly
Glucocorticoid Mediated Signaling Pathway
Positive Regulation Of Renal Water Transport
Regulation Of Cellular Process
Nitrogen Compound Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Signal Transduction
Cellular Response To CAMP
Cellular Homeostasis
Regulation Of Mitotic Cell Cycle
Platelet Activation
Tagcloud
?
adr
alternatively
b16f10
deliver
emphasize
eukaryote
eventually
evolving
g0
gep
hct116
housekeeping
hyaluronan
kind
lnps
manipulating
mcf7
nar
nci
polysome
res
retrieved
rnai
run
seeking
sirnas
ubiquitously
unstable
vital
Tagcloud (Difference)
?
adr
alternatively
b16f10
deliver
emphasize
eukaryote
eventually
evolving
g0
gep
hct116
housekeeping
hyaluronan
kind
lnps
manipulating
mcf7
nar
nci
polysome
res
retrieved
rnai
run
seeking
sirnas
ubiquitously
unstable
vital
Tagcloud (Intersection)
?