ATP2A2

Name	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
Structure
Novel Interactors	3 novel interactors: FGL2 SMCO4 UNG
Interactors	20 interactors: ARLN BCL2 CAMK2A CCR4 CEBPA CHRM5 ELN F2RL1 FILNC1 HGS IRS1 IRS2 MDM2 PLN S100A1 SPP1 SRI TNFAIP3 TRIM14 TTC3
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Intercalated Disc Longitudinal Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Platelet Dense Tubular Network Membrane Sarcoplasmic Reticulum Membrane Calcium Ion-transporting ATPase Complex Ribbon Synapse
	Molecular Function	Nucleotide Binding Calcium Channel Regulator Activity P-type Calcium Transporter Activity Calcium Ion Binding Protein Binding ATP Binding ATP Hydrolysis Activity Enzyme Binding Transmembrane Transporter Binding S100 Protein Binding Metal Ion Binding P-type Calcium Transporter Activity Involved In Regulation Of Cardiac Muscle Cell Membrane Potential LncRNA Binding
	Biological Process	Autophagosome Assembly Regulation Of The Force Of Heart Contraction Muscle System Process Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Regulation Of Muscle Contraction ER-nucleus Signaling Pathway Cell Adhesion Epidermis Development Positive Regulation Of Heart Rate Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Transition Between Fast And Slow Fiber Cardiac Muscle Hypertrophy In Response To Stress Autophagosome Membrane Docking Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration T-tubule Organization Monoatomic Ion Transmembrane Transport Cellular Response To Oxidative Stress Response To Endoplasmic Reticulum Stress Negative Regulation Of Heart Contraction Relaxation Of Cardiac Muscle Neuron Cellular Homeostasis Sarcoplasmic Reticulum Calcium Ion Transport Calcium Ion Transmembrane Transport Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Organelle Localization By Membrane Tethering Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Regulation Of Cardiac Conduction Calcium Ion Import Into Sarcoplasmic Reticulum Mitochondrion-endoplasmic Reticulum Membrane Tethering
Pathways	Pre-NOTCH Processing in Golgi Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases
Drugs	Ritodrine Desflurane Sevoflurane Istaroxime
Diseases	Acrokeratosis verruciformis Darier disease; Dyskeratosis follicularis
GWAS	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Glucose homeostasis traits ( 25524916 ) Protein quantitative trait loci ( 18464913 ) QT interval ( 24952745 29874175 ) Schizophrenia ( 25056061 28991256 29483656 30285260 ) Waist circumference ( 28552196 )
Entrez ID	488
HPRD ID	00161
Ensembl ID	ENSG00000174437
Uniprot IDs	A0A0S2Z3L2 P16615
PDB IDs	5ZTF 6JJU 6LLE 6LLY 6LN5 6LN6 6LN7 6LN8 6LN9 7BT2 7E7S 7W7T 7W7U 7W7V 7W7W
GO Terms Enriched among Interactors ?	Negative Regulation Of Multicellular Organismal Process Response To Hormone Protease Binding Positive Regulation Of Transport Regulation Of Secretion Regulation Of Secretion By Cell Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Transport Regulation Of Hormone Secretion Regulation Of Biological Quality Signal Transduction Response To Lipid Positive Regulation Of Fatty Acid Beta-oxidation Regulation Of Insulin Secretion Regulation Of System Process Negative Regulation Of B Cell Apoptotic Process Regulation Of Protein Localization Regulation Of Multicellular Organismal Process Response To Vitamin Regulation Of Peptide Hormone Secretion Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Fatty Acid Oxidation Regulation Of Heart Contraction Sarcoplasmic Reticulum Negative Regulation Of Heart Rate Response To Steroid Hormone Regulation Of Calcium Ion Transport Negative Regulation Of Transport Protein Domain Specific Binding Regulation Of Fatty Acid Beta-oxidation Phosphatidylinositol 3-kinase Binding Positive Regulation Of Glycogen Biosynthetic Process Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Relaxation Of Muscle Regulation Of Protein Transport Tolerance Induction Calcium Ion Transport Response To Hydrogen Peroxide Regulation Of B Cell Apoptotic Process Regulation Of Blood Circulation Ubiquitin Binding Regulation Of Heart Rate Negative Regulation Of Heart Contraction Regulation Of Protein Secretion Insulin Receptor Binding Negative Regulation Of Blood Circulation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Transmembrane Transport Protein Polyubiquitination Regulation Of Cellular Localization