ATP2A2 and IRS1

Number of citations of the paper that reports this interaction (PMID 9295312)
7

Data Source:
HPRD (in vitro, in vivo)

		ATP2A2	IRS1
Gene Name		ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	insulin receptor substrate 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Intercalated Disc Longitudinal Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Platelet Dense Tubular Network Membrane Sarcoplasmic Reticulum Membrane Calcium Ion-transporting ATPase Complex	Nucleus Cytoplasm Cytosol Plasma Membrane Insulin Receptor Complex Caveola Ciliary Basal Body Intracellular Membrane-bounded Organelle
	Molecular Function	Calcium-transporting ATPase Activity Calcium Ion Binding Protein Binding ATP Binding Protein C-terminus Binding Enzyme Binding S100 Protein Binding Metal Ion Binding Calcium-transporting ATPase Activity Involved In Regulation Of Cardiac Muscle Cell Membrane Potential	Signal Transducer Activity Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Kinase C Binding Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Protein Binding SH2 Domain Binding Phosphatidylinositol 3-kinase Binding
	Biological Process	Regulation Of The Force Of Heart Contraction Cellular Calcium Ion Homeostasis ER-nucleus Signaling Pathway Cell Adhesion Blood Coagulation Metabolic Process Epidermis Development Positive Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Ion Transmembrane Transport Negative Regulation Of Heart Contraction Transmembrane Transport Relaxation Of Cardiac Muscle Sarcoplasmic Reticulum Calcium Ion Transport Calcium Ion Transmembrane Transport Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Calcium Ion Import Into Sarcoplasmic Reticulum	Positive Regulation Of Mesenchymal Cell Proliferation Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Glucose Metabolic Process Phosphatidylinositol 3-kinase Signaling Lipid Catabolic Process Positive Regulation Of Cell Migration Mammary Gland Development Positive Regulation Of Fatty Acid Beta-oxidation Response To Insulin Cellular Response To Insulin Stimulus Protein Localization To Nucleus Fc-epsilon Receptor Signaling Pathway Glucose Homeostasis Response To Peptide Hormone Protein Kinase B Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Secretion Insulin-like Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Glucose Import In Response To Insulin Stimulus
Pathways		Ion transport by P-type ATPases Ion channel transport Pre-NOTCH Processing in Golgi Platelet homeostasis Reduction of cytosolic Ca++ levels Signaling by NOTCH Pre-NOTCH Expression and Processing Platelet calcium homeostasis	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade SOS-mediated signalling PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Signaling by Leptin Growth hormone receptor signaling Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R IRS activation PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling Cytokine Signaling in Immune system IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR IRS-mediated signalling Signal attenuation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade
Drugs			[4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID
Diseases
GWAS		Protein quantitative trait loci ( 18464913)	Adiponectin levels ( 22479202) Adiposity ( 21706003) Fasting insulin-related traits (interaction with BMI) ( 22581228) HDL cholesterol ( 20686565) Triglycerides ( 20686565) Type 2 diabetes ( 20581827) Type 2 diabetes and other traits ( 19734900) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Protein-Protein Interactions		9 interactors: BCL2 CAMK2A HGS IRS1 IRS2 MDM2 PLN S100A1 SPP1	73 interactors: AKT1 ALK AP3S1 APP ATP2A1 ATP2A2 ATP2A3 BCL2L1 BCR CAV1 CDH1 CHUK CRK CSNK2A1 CSNK2B EGFR ERBB2 FBXO25 FBXW8 FER FES FYN GHR GRB10 GRB14 GRB2 IGF1R IKBKB IL4R INSR JAK1 JAK2 JAK3 MAPK1 MAPK8 MAPK9 MTOR NCK2 NEDD4 NPM1 NTRK1 PDPK1 PHIP PIK3R1 PIK3R2 PIK3R3 PLCG2 PRKCD PRKCG PRKCQ PRKCZ PTK2 PTPN1 PTPN11 PTPRC PTPRF PTPRU RAD51 ROCK1 RPS6KB1 RPTOR SH2B1 SHC1 SIK2 SOCS1 SOCS3 TUB TYK2 UBTF YWHAB YWHAE YWHAG YWHAZ
Entrez ID		488	3667
HPRD ID		00161	00943
Ensembl ID		ENSG00000174437	ENSG00000169047
Uniprot IDs		P16615	P35568
PDB IDs			1IRS 1K3A 1QQG 2Z8C
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transport Regulation Of Cellular Localization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Hormone Regulation Of Calcium Ion Transport Regulation Of Ion Transport Defense Response Response To Organic Substance Innate Immune Response Negative Regulation Of Ion Transport Response To Organonitrogen Compound Positive Regulation Of Fatty Acid Beta-oxidation Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Transport Positive Regulation Of Glycogen Biosynthetic Process Cellular Response To Stimulus Response To Peptide Hormone Phosphatidylinositol-mediated Signaling Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Fatty Acid Oxidation Response To Steroid Hormone Regulation Of Transmembrane Transporter Activity Response To Peptide Cell Surface Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Growth Hormone Receptor Signaling Pathway Immune System Process Cellular Response To Fibroblast Growth Factor Stimulus Signal Transduction Response To Fibroblast Growth Factor Positive Regulation Of Lipid Catabolic Process Cellular Response To Growth Hormone Stimulus Immune Response Neurotrophin TRK Receptor Signaling Pathway Regulation Of Secretion Positive Regulation Of Fatty Acid Metabolic Process Response To Ischemia Regulation Of Glycogen Biosynthetic Process Regulation Of Fatty Acid Oxidation Neurotrophin Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Fc-epsilon Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Response To Stimulus Signaling	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organonitrogen Compound Cell Surface Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Response To Organic Substance Cellular Response To Organic Substance Response To Organonitrogen Compound Signal Transduction Intracellular Signal Transduction Signaling Regulation Of Signal Transduction Response To Peptide Hormone Cell Communication Cellular Response To Hormone Stimulus Insulin Receptor Signaling Pathway Response To Peptide Cellular Response To Stimulus Response To Hormone Regulation Of Signaling Regulation Of Immune Response Positive Regulation Of Signal Transduction Cellular Response To Insulin Stimulus Innate Immune Response Regulation Of Kinase Activity Regulation Of Phosphorylation Regulation Of Immune System Process Immune Response Response To Stimulus Response To Insulin Defense Response Regulation Of Phosphorus Metabolic Process Response To Stress Immune System Process Fc Receptor Signaling Pathway Blood Coagulation Hemostasis Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Body Fluid Levels Regulation Of Protein Metabolic Process Phosphate-containing Compound Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Phosphorylation Neurotrophin Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Protein Autophosphorylation Response To Wounding Regulation Of Protein Phosphorylation
Tagcloud ?			action adipocytes biochem biophys coimmunoprecipitation coincided commun docking evidenced extent gh initiating insulin involvement kda kinase phosphatidylinositol phosphorylated pi postreceptor res ridderstrale seems substrate thereby tornqvist tyrosine wortmannin
Tagcloud (Difference) ?			action adipocytes biochem biophys coimmunoprecipitation coincided commun docking evidenced extent gh initiating insulin involvement kda kinase phosphatidylinositol phosphorylated pi postreceptor res ridderstrale seems substrate thereby tornqvist tyrosine wortmannin
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