ATP2A2 and PLN

Number of citations of the paper that reports this interaction (PMID 10809745)
27

Data Source:
HPRD (in vitro, in vivo)

		ATP2A2	PLN
Gene Name		ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	phospholamban
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Intercalated Disc Longitudinal Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Platelet Dense Tubular Network Membrane Sarcoplasmic Reticulum Membrane Calcium Ion-transporting ATPase Complex	Mitochondrion Endoplasmic Reticulum Membrane Mitochondrial Membrane Vesicle Sarcoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm Calcium Ion-transporting ATPase Complex
	Molecular Function	Calcium-transporting ATPase Activity Calcium Ion Binding Protein Binding ATP Binding Protein C-terminus Binding Enzyme Binding S100 Protein Binding Metal Ion Binding Calcium-transporting ATPase Activity Involved In Regulation Of Cardiac Muscle Cell Membrane Potential	Enzyme Inhibitor Activity Calcium Channel Regulator Activity Protein Binding ATPase Inhibitor Activity Identical Protein Binding ATPase Binding
	Biological Process	Regulation Of The Force Of Heart Contraction Cellular Calcium Ion Homeostasis ER-nucleus Signaling Pathway Cell Adhesion Blood Coagulation Metabolic Process Epidermis Development Positive Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Ion Transmembrane Transport Negative Regulation Of Heart Contraction Transmembrane Transport Relaxation Of Cardiac Muscle Sarcoplasmic Reticulum Calcium Ion Transport Calcium Ion Transmembrane Transport Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Calcium Ion Import Into Sarcoplasmic Reticulum	Regulation Of The Force Of Heart Contraction Calcium Ion Transport Blood Circulation Regulation Of Heart Contraction Response To Zinc Ion Negative Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of ATPase Activity Response To Insulin Response To Testosterone Negative Regulation Of Catalytic Activity Cardiac Muscle Tissue Development Protein Homooligomerization Cytosolic Calcium Ion Homeostasis Regulation Of Calcium Ion Transport Negative Regulation Of Calcium Ion Transport Relaxation Of Cardiac Muscle Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cardiac Muscle Cell Contraction Adrenergic Receptor Signaling Pathway Involved In Heart Process Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of The Force Of Heart Contraction By Cardiac Conduction Negative Regulation Of Calcium Ion Import Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Calcium Ion Binding Regulation Of Calcium-transporting ATPase Activity Negative Regulation Of Calcium-transporting ATPase Activity Regulation Of Relaxation Of Cardiac Muscle Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum
Pathways		Ion transport by P-type ATPases Ion channel transport Pre-NOTCH Processing in Golgi Platelet homeostasis Reduction of cytosolic Ca++ levels Signaling by NOTCH Pre-NOTCH Expression and Processing Platelet calcium homeostasis	Ion transport by P-type ATPases Ion channel transport
Drugs
Diseases
GWAS		Protein quantitative trait loci ( 18464913)	Cardiac structure and function ( 19584346) QT interval ( 23166209 19305408 19305409 19587794) Ventricular conduction ( 21076409)
Protein-Protein Interactions		9 interactors: BCL2 CAMK2A HGS IRS1 IRS2 MDM2 PLN S100A1 SPP1	11 interactors: ATP2A1 ATP2A2 DMPK DVL3 EDA LDLRAD1 PPP1R3A PRKACA S100A1 SLN TMEM79
Entrez ID		488	5350
HPRD ID		00161	01395
Ensembl ID		ENSG00000174437	ENSG00000198523
Uniprot IDs		P16615	P26678 Q5R352
PDB IDs			1K9N 1KCH 1PLN 1PLP 1PSL 1ZLL 2HYN
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transport Regulation Of Cellular Localization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Hormone Regulation Of Calcium Ion Transport Regulation Of Ion Transport Defense Response Response To Organic Substance Innate Immune Response Negative Regulation Of Ion Transport Response To Organonitrogen Compound Positive Regulation Of Fatty Acid Beta-oxidation Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Transport Positive Regulation Of Glycogen Biosynthetic Process Cellular Response To Stimulus Response To Peptide Hormone Phosphatidylinositol-mediated Signaling Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Fatty Acid Oxidation Response To Steroid Hormone Regulation Of Transmembrane Transporter Activity Response To Peptide Cell Surface Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Growth Hormone Receptor Signaling Pathway Immune System Process Cellular Response To Fibroblast Growth Factor Stimulus Signal Transduction Response To Fibroblast Growth Factor Positive Regulation Of Lipid Catabolic Process Cellular Response To Growth Hormone Stimulus Immune Response Neurotrophin TRK Receptor Signaling Pathway Regulation Of Secretion Positive Regulation Of Fatty Acid Metabolic Process Response To Ischemia Regulation Of Glycogen Biosynthetic Process Regulation Of Fatty Acid Oxidation Neurotrophin Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Fc-epsilon Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Response To Stimulus Signaling	Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Regulation Of Heart Contraction Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Regulation Of Striated Muscle Contraction Sarcoplasmic Reticulum Calcium Ion Transport Chemical Homeostasis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Metal Ion Homeostasis Regulation Of Muscle Contraction Relaxation Of Muscle Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Cellular Chemical Homeostasis Ion Homeostasis Regulation Of Calcium Ion Transport Regulation Of Body Fluid Levels Regulation Of The Force Of Heart Contraction Calcium Ion Import Endoplasmic Reticulum Calcium Ion Homeostasis Homeostatic Process Cellular Homeostasis Epidermis Development Multicellular Organismal Water Homeostasis Calcium Ion Transport Water Homeostasis Nuclear Envelope Organization Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Positive Regulation Of Dense Core Granule Biogenesis Calcium Ion Import Into Sarcoplasmic Reticulum Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Regulation Of Cation Channel Activity Intracellular Signal Transduction Programmed Cell Death Regulation Of Ion Transmembrane Transport Blood Coagulation Hemostasis Cell Death Death Calcium-mediated Signaling Hair Follicle Development Hair Cycle Process Epithelium Development
Tagcloud ?			augment axillary ccr7 cd45 clue conditioned cues deadly drained emerge fivefold infiltrated infiltrating intriguingly leukocyte leukocytes lymph mcf microenvironment nln nlns nodes plns secreted secretions skbr3 subsets tals tributaries
Tagcloud (Difference) ?			augment axillary ccr7 cd45 clue conditioned cues deadly drained emerge fivefold infiltrated infiltrating intriguingly leukocyte leukocytes lymph mcf microenvironment nln nlns nodes plns secreted secretions skbr3 subsets tals tributaries
Tagcloud (Intersection) ?