ATP2A2 and S100A1

Number of citations of the paper that reports this interaction (PMID 12804600)
12

Data Source:
HPRD (in vitro, in vivo)

		ATP2A2	S100A1
Gene Name		ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	S100 calcium binding protein A1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Intercalated Disc Longitudinal Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Platelet Dense Tubular Network Membrane Sarcoplasmic Reticulum Membrane Calcium Ion-transporting ATPase Complex	Nucleus Sarcoplasmic Reticulum Z Disc M Band Neuron Projection Protein Complex
	Molecular Function	Calcium-transporting ATPase Activity Calcium Ion Binding Protein Binding ATP Binding Protein C-terminus Binding Enzyme Binding S100 Protein Binding Metal Ion Binding Calcium-transporting ATPase Activity Involved In Regulation Of Cardiac Muscle Cell Membrane Potential	Calcium Ion Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Calcium-dependent Protein Binding ATPase Binding
	Biological Process	Regulation Of The Force Of Heart Contraction Cellular Calcium Ion Homeostasis ER-nucleus Signaling Pathway Cell Adhesion Blood Coagulation Metabolic Process Epidermis Development Positive Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Ion Transmembrane Transport Negative Regulation Of Heart Contraction Transmembrane Transport Relaxation Of Cardiac Muscle Sarcoplasmic Reticulum Calcium Ion Transport Calcium Ion Transmembrane Transport Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Calcium Ion Import Into Sarcoplasmic Reticulum	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Heart Contraction Substantia Nigra Development Intracellular Signal Transduction Positive Regulation Of Voltage-gated Calcium Channel Activity
Pathways		Ion transport by P-type ATPases Ion channel transport Pre-NOTCH Processing in Golgi Platelet homeostasis Reduction of cytosolic Ca++ levels Signaling by NOTCH Pre-NOTCH Expression and Processing Platelet calcium homeostasis
Drugs			Olopatadine
Diseases
GWAS		Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		9 interactors: BCL2 CAMK2A HGS IRS1 IRS2 MDM2 PLN S100A1 SPP1	24 interactors: ACTA1 AGER ANXA6 ATP2A2 CACYBP CAPZA1 DES FKBP4 GFAP GJA1 MDM2 NIF3L1 PGM1 PLB1 PLEKHF2 PLN PPID PYGM RYR1 S100A2 S100A4 S100B S100P SYN1
Entrez ID		488	6271
HPRD ID		00161	01489
Ensembl ID		ENSG00000174437	ENSG00000160678
Uniprot IDs		P16615	P23297
PDB IDs			2L0P 2LHL 2LLS 2LLT 2LLU 2LP2 2LP3 2LUX
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transport Regulation Of Cellular Localization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Hormone Regulation Of Calcium Ion Transport Regulation Of Ion Transport Defense Response Response To Organic Substance Innate Immune Response Negative Regulation Of Ion Transport Response To Organonitrogen Compound Positive Regulation Of Fatty Acid Beta-oxidation Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Transport Positive Regulation Of Glycogen Biosynthetic Process Cellular Response To Stimulus Response To Peptide Hormone Phosphatidylinositol-mediated Signaling Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Fatty Acid Oxidation Response To Steroid Hormone Regulation Of Transmembrane Transporter Activity Response To Peptide Cell Surface Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Growth Hormone Receptor Signaling Pathway Immune System Process Cellular Response To Fibroblast Growth Factor Stimulus Signal Transduction Response To Fibroblast Growth Factor Positive Regulation Of Lipid Catabolic Process Cellular Response To Growth Hormone Stimulus Immune Response Neurotrophin TRK Receptor Signaling Pathway Regulation Of Secretion Positive Regulation Of Fatty Acid Metabolic Process Response To Ischemia Regulation Of Glycogen Biosynthetic Process Regulation Of Fatty Acid Oxidation Neurotrophin Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Fc-epsilon Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Response To Stimulus Signaling	Muscle System Process Response To Abiotic Stimulus Regulation Of Cardiac Muscle Cell Contraction Regulation Of Muscle Contraction Regulation Of Heart Contraction Regulation Of Cardiac Muscle Cell Membrane Potential Protein Complex Assembly Sarcoplasmic Reticulum Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Muscle Contraction Relaxation Of Cardiac Muscle Regulation Of Striated Muscle Contraction Glycogen Catabolic Process Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Polysaccharide Catabolic Process Calcium Ion Transport Relaxation Of Muscle Striated Muscle Tissue Development Negative Regulation Of Heart Contraction Skeletal Muscle Fiber Development Response To Hormone Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Response To Metal Ion Muscle Tissue Development Cellular Component Assembly Myotube Cell Development Regulation Of Cellular Localization Cellular Carbohydrate Catabolic Process Regulation Of The Force Of Heart Contraction Actin-myosin Filament Sliding Muscle Filament Sliding Response To Wounding Regulation Of Ion Homeostasis Regulation Of Actin Filament-based Process Cellular Metal Ion Homeostasis Cellular Response To Alkaloid Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Astrocyte Differentiation Cytosolic Calcium Ion Homeostasis Cellular Cation Homeostasis Actin-mediated Cell Contraction Cellular Ion Homeostasis Response To Peptide Hormone Cardiac Conduction Tissue Development Negative Regulation Of Striated Muscle Tissue Development Steroid Hormone Receptor Complex Assembly Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Positive Regulation Of Schwann Cell Proliferation
Tagcloud ?			ablation ad ascertain astrocytosis burden collectively demonstration detrimental elucidated gfap gsk3beta iba1 identifies indirectly microgliosis modulates neuroinflammation normalizing pathobiology pc12 plaque po4 psapp ryanodine ryr sensor twelve undetectable uses
Tagcloud (Difference) ?			ablation ad ascertain astrocytosis burden collectively demonstration detrimental elucidated gfap gsk3beta iba1 identifies indirectly microgliosis modulates neuroinflammation normalizing pathobiology pc12 plaque po4 psapp ryanodine ryr sensor twelve undetectable uses
Tagcloud (Intersection) ?