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TNKS1BP1 and TNKS
Number of citations of the paper that reports this interaction (PMID
11854288
)
32
Data Source:
HPRD
(two hybrid, in vitro, in vivo)
TNKS1BP1
TNKS
Gene Name
tankyrase 1 binding protein 1, 182kDa
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Nuclear Telomeric Heterochromatin
Cytoplasm
Cytosol
Cytoskeleton
Plasma Membrane
CCR4-NOT Complex
Golgi Membrane
Pericentriolar Material
Chromosome, Centromeric Region
Chromosome, Telomeric Region
Nuclear Chromosome, Telomeric Region
Spindle Pole
Nuclear Pore
Golgi Apparatus
Cytosol
Nuclear Membrane
Molecular Function
Enzyme Binding
Ankyrin Binding
NAD+ ADP-ribosyltransferase Activity
Protein Binding
Zinc Ion Binding
Biological Process
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Nuclear-transcribed MRNA Poly(A) Tail Shortening
Telomere Maintenance Via Telomerase
Gene Expression
Protein Polyubiquitination
Protein ADP-ribosylation
Mitotic Spindle Organization
Mitotic Nuclear Division
Protein Transport
Wnt Signaling Pathway
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of DNA Binding
Positive Regulation Of Transcription From RNA Polymerase II Promoter
MRNA Transport
Spindle Assembly
Cell Division
Protein Localization To Chromosome, Telomeric Region
Protein Poly-ADP-ribosylation
Protein Auto-ADP-ribosylation
Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways
Deadenylation of mRNA
Deadenylation-dependent mRNA decay
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TCF dependent signaling in response to WNT
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
degradation of AXIN
Signaling by Wnt
Signaling by WNT in cancer
Drugs
Diseases
GWAS
Metabolite levels (
22916037
)
Protein-Protein Interactions
3 interactors:
CSNK2A1
TNKS
TNKS2
14 interactors:
DISC1
FANCD2
FNBP1
LNPEP
MCL1
NUMA1
POT1
RNF146
SH3BP5
TERF1
TNIK
TNKS1BP1
TNKS2
VPS33A
Entrez ID
85456
8658
HPRD ID
06164
04490
Ensembl ID
ENSG00000149115
ENSG00000173273
Uniprot IDs
Q9C0C2
E7EQ52
O95271
PDB IDs
2RF5
3UDD
3UH2
3UH4
4DVI
4I9I
4K4E
4K4F
4KRS
4LI6
4LI7
4LI8
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Telomere Maintenance Via Telomerase
Protein Auto-ADP-ribosylation
Protein Localization To Chromosome, Telomeric Region
Positive Regulation Of Telomere Maintenance
Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of Wnt Signaling Pathway
Regulation Of Chromosome Organization
Regulation Of Telomere Maintenance
Wnt Signaling Pathway
Regulation Of Wnt Signaling Pathway
Protein ADP-ribosylation
Protein Localization To Chromosome
Positive Regulation Of DNA Replication
Regulation Of Organelle Organization
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of DNA Replication
Positive Regulation Of DNA Metabolic Process
Protein Polyubiquitination
Positive Regulation Of Signal Transduction
Regulation Of Canonical Wnt Signaling Pathway
Protein Poly-ADP-ribosylation
Regulation Of Cellular Component Organization
Macromolecule Glycosylation
Protein Glycosylation
Glycosylation
Glycoprotein Biosynthetic Process
Positive Regulation Of Organelle Organization
Glycoprotein Metabolic Process
Protein Localization To Organelle
Regulation Of Signal Transduction
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Regulation Of Growth
Regulation Of Signaling
Cell Surface Receptor Signaling Pathway
Mitotic Cell Cycle Process
Cellular Protein Modification Process
Mitotic Cell Cycle
Positive Regulation Of Metabolic Process
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Mitotic Spindle Checkpoint
Negative Regulation Of Chromosome Segregation
Mitotic Spindle Organization
Cell Cycle Process
Carbohydrate Metabolic Process
Negative Regulation Of DNA Binding
Peptidyl-threonine Phosphorylation
Spindle Checkpoint
Regulation Of Mitotic Sister Chromatid Separation
Telomere Maintenance Via Telomerase
Regulation Of Telomere Maintenance Via Telomerase
Regulation Of Telomere Maintenance
RNA-dependent DNA Replication
Telomere Maintenance Via Telomere Lengthening
Negative Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of Telomere Maintenance Via Telomerase
Telomere Maintenance
Negative Regulation Of Telomerase Activity
Negative Regulation Of Telomere Maintenance
Wnt Signaling Pathway
Positive Regulation Of Telomere Maintenance
Regulation Of Telomerase Activity
Regulation Of DNA Replication
Negative Regulation Of DNA Biosynthetic Process
Positive Regulation Of Wnt Signaling Pathway
Protein Polyubiquitination
Organelle Organization
Regulation Of Chromosome Organization
Regulation Of DNA Biosynthetic Process
Negative Regulation Of DNA Replication
DNA Replication
Positive Regulation Of Signal Transduction
Positive Regulation Of DNA Strand Elongation
Negative Regulation Of Transferase Activity
Regulation Of Wnt Signaling Pathway
Positive Regulation Of DNA Replication
Homeostatic Process
Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
Negative Regulation Of Chromosome Organization
Negative Regulation Of DNA Metabolic Process
Positive Regulation Of Organelle Organization
Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Telomeric Loop Formation
Age-dependent Telomere Shortening
Telomere Formation Via Telomerase
G2/M Transition Of Mitotic Cell Cycle
Chromosome Organization
Telomere Maintenance Via Telomere Shortening
Protein Auto-ADP-ribosylation
Positive Regulation Of Canonical Wnt Signaling Pathway
DNA Metabolic Process
Positive Regulation Of DNA Metabolic Process
Telomere Capping
Protein Localization To Chromosome, Telomeric Region
Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Helicase Activity
Protein Localization
Regulation Of Cellular Component Organization
Positive Regulation Of Telomerase Activity
Tagcloud
?
acd
additive
assuming
caucasian
corroborated
eleven
elusive
haplotype
haplotypes
incident
leukocyte
multivariable
pot1
prespecified
shortening
t2d
tagging
telomere
tep1
terc
terf1
terf2
terf2ip
tert
tnks2
tsnps
ucp1
uncorrected
variation
Tagcloud (Difference)
?
acd
additive
assuming
caucasian
corroborated
eleven
elusive
haplotype
haplotypes
incident
leukocyte
multivariable
pot1
prespecified
shortening
t2d
tagging
telomere
tep1
terc
terf1
terf2
terf2ip
tert
tnks2
tsnps
ucp1
uncorrected
variation
Tagcloud (Intersection)
?