TNKS1BP1 and TNKS2

Number of citations of the paper that reports this interaction (PMID 11854288)
32

Data Source:
BioGRID (two hybrid)
HPRD (in vivo)

		TNKS1BP1	TNKS2
Gene Name		tankyrase 1 binding protein 1, 182kDa	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Telomeric Heterochromatin Cytoplasm Cytosol Cytoskeleton Plasma Membrane CCR4-NOT Complex	Golgi Membrane Pericentriolar Material Nuclear Chromosome, Telomeric Region Nucleus Nuclear Envelope Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Enzyme Binding Ankyrin Binding	NAD+ ADP-ribosyltransferase Activity Protein Binding Enzyme Binding Metal Ion Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Telomere Maintenance Via Telomerase Gene Expression	Protein Polyubiquitination Protein ADP-ribosylation Wnt Signaling Pathway Positive Regulation Of Telomere Maintenance Via Telomerase Multicellular Organism Growth Regulation Of Multicellular Organism Growth Protein Localization To Chromosome, Telomeric Region Protein Auto-ADP-ribosylation Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Deadenylation of mRNA Deadenylation-dependent mRNA decay	misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: CSNK2A1 TNKS TNKS2	8 interactors: GRB14 LNPEP MAPK1 SH3BP2 TERF1 TNKS TNKS1BP1 ZNF512B
Entrez ID		85456	80351
HPRD ID		06164	06182
Ensembl ID		ENSG00000149115	ENSG00000107854
Uniprot IDs		Q9C0C2	Q9H2K2
PDB IDs			2Y0I 3KR7 3KR8 3MHJ 3MHK 3P0N 3P0P 3P0Q 3TWQ 3TWR 3TWS 3TWT 3TWU 3TWV 3TWW 3TWX 3U9H 3U9Y 3UA9 3W51 4AVU 4AVW 4BFP 4HKI 4HKK 4HKN 4HL5 4HLF 4HLG 4HLH 4HLK 4HLM 4HMH 4HYF 4IUE 4J1Z 4J21 4J22 4J3L 4J3M
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Telomere Maintenance Via Telomerase Protein Auto-ADP-ribosylation Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Wnt Signaling Pathway Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Protein ADP-ribosylation Protein Localization To Chromosome Positive Regulation Of DNA Replication Regulation Of Organelle Organization Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of DNA Replication Positive Regulation Of DNA Metabolic Process Protein Polyubiquitination Positive Regulation Of Signal Transduction Regulation Of Canonical Wnt Signaling Pathway Protein Poly-ADP-ribosylation Regulation Of Cellular Component Organization Macromolecule Glycosylation Protein Glycosylation Glycosylation Glycoprotein Biosynthetic Process Positive Regulation Of Organelle Organization Glycoprotein Metabolic Process Protein Localization To Organelle Regulation Of Signal Transduction Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Growth Regulation Of Signaling Cell Surface Receptor Signaling Pathway Mitotic Cell Cycle Process Cellular Protein Modification Process Mitotic Cell Cycle Positive Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Mitotic Spindle Organization Cell Cycle Process Carbohydrate Metabolic Process Negative Regulation Of DNA Binding Peptidyl-threonine Phosphorylation Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation	Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance RNA-dependent DNA Replication Telomere Maintenance Via Telomere Lengthening Peptidyl-threonine Phosphorylation Telomere Maintenance Positive Regulation Of Signal Transduction MAPK Import Into Nucleus Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Peptidyl-serine Phosphorylation Regulation Of DNA Replication Telomeric Loop Formation Age-dependent Telomere Shortening Protein Poly-ADP-ribosylation Positive Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomere Shortening Regulation Of Golgi Inheritance Protein Auto-ADP-ribosylation Protein Polyubiquitination Caveolin-mediated Endocytosis Cytosine Metabolic Process Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Chromosome Organization Regulation Of Golgi Organization Positive Regulation Of Telomere Maintenance Regulation Of Organelle Organization Cellular Macromolecule Biosynthetic Process Replicative Cell Aging Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Macromolecule Biosynthetic Process Regulation Of Nuclear Cell Cycle DNA Replication Negative Regulation Of Telomerase Activity Negative Regulation Of Telomere Maintenance DNA Replication Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Microtubule Polymerization Mitotic Nuclear Division Regulation Of Telomerase Activity Positive Regulation Of Peptidyl-threonine Phosphorylation ERK1 And ERK2 Cascade
Tagcloud ?			abt actively adp azd bsi continues crystal detailed explored guide heightened indications inhibitors insight manifesting modes parp parp1 parp2 parp5a parp5b poly rational relevance ribose stranded tankyrase tnks1 valuable
Tagcloud (Difference) ?			abt actively adp azd bsi continues crystal detailed explored guide heightened indications inhibitors insight manifesting modes parp parp1 parp2 parp5a parp5b poly rational relevance ribose stranded tankyrase tnks1 valuable
Tagcloud (Intersection) ?