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BCL2L11 and FGL1
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
BCL2L11
FGL1
Description
BCL2 like 11
fibrinogen like 1
Image
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Cytosol
Microtubule
Endomembrane System
Membrane
Intracellular Membrane-bounded Organelle
Bcl-2 Family Protein Complex
BIM-BCL-xl Complex
BIM-BCL-2 Complex
Extracellular Region
Fibrinogen Complex
Extracellular Space
Extracellular Matrix
Molecular Function
Protein Binding
Microtubule Binding
Protein Kinase Binding
Protein Binding
Biological Process
In Utero Embryonic Development
Leukocyte Homeostasis
B Cell Homeostasis
Kidney Development
Lymphocyte Homeostasis
Myeloid Cell Homeostasis
Apoptotic Process
Meiosis I
Cell-matrix Adhesion
Spermatogenesis
Male Gonad Development
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Post-embryonic Development
Mammary Gland Development
Positive Regulation Of Protein-containing Complex Assembly
Response To Endoplasmic Reticulum Stress
Tube Formation
Odontogenesis Of Dentin-containing Tooth
Regulation Of Apoptotic Process
T Cell Homeostasis
Positive Regulation Of Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Ear Development
Positive Regulation Of Cell Cycle
Regulation Of Organ Growth
Developmental Pigmentation
Regulation Of Developmental Pigmentation
Spleen Development
Thymus Development
Lymphocyte Apoptotic Process
Positive Regulation Of Lymphocyte Apoptotic Process
T Cell Apoptotic Process
Positive Regulation Of T Cell Apoptotic Process
Thymocyte Apoptotic Process
Cellular Response To Glucocorticoid Stimulus
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Apoptotic Process Involved In Embryonic Digit Morphogenesis
Positive Regulation Of IRE1-mediated Unfolded Protein Response
Positive Regulation Of Fibroblast Apoptotic Process
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Adaptive Immune Response
Immune System Process
Blood Coagulation
Regulation Of Immune Response
Negative Regulation Of T Cell Activation
Hepatocyte Proliferation
Pathways
Activation of BIM and translocation to mitochondria
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
NRAGE signals death through JNK
Signaling by BRAF and RAF1 fusions
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
RUNX3 regulates BCL2L11 (BIM) transcription
FLT3 Signaling
FOXO-mediated transcription of cell death genes
Drugs
Diseases
GWAS
A body shape index (
34021172
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Alopecia areata (
25608926
)
Asthma (
30929738
32296059
)
Asthma (childhood onset) (
30929738
)
B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) (
28112199
)
Breast cancer (
29059683
)
Breast cancer, ovarian cancer or prostate cancer (pleiotropy) (
27432226
)
Chronic lymphocytic leukemia (
24292274
28165464
23770605
26956414
18758461
)
Composite immunoglobulin trait (IgA x IgG/IgM) (
28628107
)
Dehydroepiandrosterone sulphate levels (
21533175
)
Eosinophil count (
32888494
27863252
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
27863252
32888494
)
Eosinophilic granulomatosis with polyangiitis (
31719529
)
Granulocyte percentage of myeloid white cells (
27863252
)
HDL cholesterol levels (
32203549
)
Heel bone mineral density (
30598549
)
High light scatter reticulocyte count (
32888494
27863252
)
High light scatter reticulocyte percentage of red cells (
32888494
27863252
)
Hip circumference adjusted for BMI (
34021172
)
Hip index (
34021172
)
Immature fraction of reticulocytes (
27863252
)
Lymphocyte count (
32888494
)
Mean corpuscular hemoglobin (
32888494
)
Mean reticulocyte volume (
32888494
)
Monocyte count (
32888494
27863252
)
Monocyte percentage of white cells (
32888494
27863252
)
Multiple sclerosis (
31604244
)
Neutrophil percentage of granulocytes (
27863252
)
Neutrophil percentage of white cells (
32888494
27863252
)
Primary sclerosing cholangitis (
27992413
21151127
)
Prostate cancer (
29892016
)
Prostate cancer (advanced) (
29892016
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
27863252
)
Sum eosinophil basophil counts (
27863252
)
Systemic lupus erythematosus (
33272962
)
Triglyceride levels (
32203549
)
Type 2 diabetes (
30054458
28869590
)
Type 2 diabetes or prostate cancer (pleiotropy) (
33290408
)
Urinary albumin-to-creatinine ratio (
32600054
)
Vitiligo (
27723757
)
Waist circumference adjusted for body mass index (
34021172
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Blood protein levels (
30072576
)
Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) (
26503814
)
Interacting Genes
31 interacting genes:
AKT1
APP
ATP6V1G1
AURKB
BCL2
BCL2A1
BCL2L1
BCL2L10
BCL2L2
BTK
CDK1
DTX2
DYNLL1
FEM1C
FGL1
GTF2I
MAGEA11
MAPK10
MAPK8
MAPK9
MCL1
MEX3D
MKRN3
PEX19
RACK1
RIOK3
SMARCB1
TRIM2
USHBP1
VDAC1
YWHAB
3 interacting genes:
BCL2L11
GLP1R
VKORC1
Entrez ID
10018
2267
HPRD ID
04828
09312
Ensembl ID
ENSG00000153094
ENSG00000104760
Uniprot IDs
A0A0C4DH20
E9PAM9
H7BZE5
O43521
Q08830
PDB IDs
1F95
2K7W
2NL9
2V6Q
2VM6
2WH6
2YQ6
2YQ7
3D7V
3FDL
3IO8
3IO9
3KJ0
3KJ1
3KJ2
4A1U
4A1W
4B4S
4D2M
4QVF
4UF3
4YJ4
4ZIE
4ZIF
4ZIH
5AGW
5AGX
5C3G
5VWV
5VWW
5VWX
5VWY
5VWZ
5VX0
5VX2
5VX3
5WOS
6QFI
6RJP
6TQQ
6UA3
6UAB
6VBX
6X8O
8T5E
7TZ2
Enriched GO Terms of Interacting Partners
?
Release Of Cytochrome C From Mitochondria
Apoptotic Mitochondrial Changes
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Channel Activity
BH3 Domain Binding
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Bcl-2 Family Protein Complex
Positive Regulation Of Apoptotic Process
Apoptotic Process
Positive Regulation Of Programmed Cell Death
Programmed Cell Death
Cell Death
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
JUN Kinase Activity
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Extrinsic Apoptotic Signaling Pathway
Mitochondrial Outer Membrane
Apoptotic Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Mitochondrion Organization
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Intrinsic Apoptotic Signaling Pathway
Response To Radiation
Regulation Of Intrinsic Apoptotic Signaling Pathway
Intracellular Signal Transduction
Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Response To Light Stimulus
Post-translational Protein Modification
Mitochondrion
Protein Modification Process
Cytosol
Protein Serine Kinase Activity
MAP Kinase Activity
Fc Receptor Signaling Pathway
Regulation Of Autophagy
Regulation Of Immune Response
Negative Regulation Of Anoikis
Regulation Of Apoptotic Signaling Pathway
Regulation Of Neuron Apoptotic Process
Regulation Of B Cell Apoptotic Process
Protein Serine/threonine Kinase Activity
Negative Regulation Of Metabolic Process
Peptidyl-threonine Phosphorylation
Immune Response-regulating Signaling Pathway
DNA Damage Response
Dendritic Cell Apoptotic Process
Response To Reactive Oxygen Species
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Glucagon-like Peptide 1 Receptor Activity
BIM-BCL-2 Complex
BIM-BCL-xl Complex
Peptidyl-glutamic Acid Carboxylation
Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor
Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity
Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity
Glucagon Receptor Activity
Apoptotic Process Involved In Embryonic Digit Morphogenesis
Response To Psychosocial Stress
Post-translational Protein Targeting To Membrane, Translocation
Cellular Response To Glucagon Stimulus
Activation Of Adenylate Cyclase Activity
Cellular Response To Hormone Stimulus
Positive Regulation Of Fibroblast Apoptotic Process
Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response
Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Ear Development
Regulation Of Developmental Pigmentation
Positive Regulation Of T Cell Apoptotic Process
Bcl-2 Family Protein Complex
Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Positive Regulation Of IRE1-mediated Unfolded Protein Response
Thymocyte Apoptotic Process
Developmental Pigmentation
Quinone Binding
Peptidyl-glutamic Acid Modification
Vitamin K Metabolic Process
Positive Regulation Of Lyase Activity
Regulation Of Biological Quality
Positive Regulation Of Adenylate Cyclase Activity
Response To Glucagon
Regulation Of Fibroblast Apoptotic Process
Regulation Of IRE1-mediated Unfolded Protein Response
Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death
Positive Regulation Of Lymphocyte Apoptotic Process
Positive Regulation Of Cyclase Activity
Response To Hormone
Apoptotic Process Involved In Morphogenesis
Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Intracellular Protein Transmembrane Transport
Regulation Of Multicellular Organismal Process
Positive Regulation Of Blood Pressure
B Cell Homeostasis
T Cell Apoptotic Process
Positive Regulation Of Membrane Permeability
Positive Regulation Of Mitochondrial Membrane Permeability
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Positive Regulation Of Leukocyte Apoptotic Process
Myeloid Cell Homeostasis
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