BCL2L11 and TRIM2

Number of citations of the paper that reports this interaction (PubMedID 21478148)
31

Data Source:
BioGRID (pull down)

		BCL2L11	TRIM2
Description		BCL2 like 11	tripartite motif containing 2
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Microtubule Endomembrane System Membrane Intracellular Membrane-bounded Organelle Bcl-2 Family Protein Complex BIM-BCL-xl Complex BIM-BCL-2 Complex	Cytoplasm
	Molecular Function	Protein Binding Microtubule Binding Protein Kinase Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	In Utero Embryonic Development Leukocyte Homeostasis B Cell Homeostasis Kidney Development Lymphocyte Homeostasis Myeloid Cell Homeostasis Apoptotic Process Meiosis I Cell-matrix Adhesion Spermatogenesis Male Gonad Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Post-embryonic Development Mammary Gland Development Positive Regulation Of Protein-containing Complex Assembly Response To Endoplasmic Reticulum Stress Tube Formation Odontogenesis Of Dentin-containing Tooth Regulation Of Apoptotic Process T Cell Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Ear Development Positive Regulation Of Cell Cycle Regulation Of Organ Growth Developmental Pigmentation Regulation Of Developmental Pigmentation Spleen Development Thymus Development Lymphocyte Apoptotic Process Positive Regulation Of Lymphocyte Apoptotic Process T Cell Apoptotic Process Positive Regulation Of T Cell Apoptotic Process Thymocyte Apoptotic Process Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Apoptotic Process Involved In Embryonic Digit Morphogenesis Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Protein Polyubiquitination Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Neuron Apoptotic Process Cellular Response To Leukemia Inhibitory Factor
Pathways		Activation of BIM and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members NRAGE signals death through JNK Signaling by BRAF and RAF1 fusions Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models RUNX3 regulates BCL2L11 (BIM) transcription FLT3 Signaling FOXO-mediated transcription of cell death genes	Interferon gamma signaling
Drugs
Diseases
GWAS		A body shape index ( 34021172) Allergic disease (asthma, hay fever or eczema) ( 29083406) Alopecia areata ( 25608926) Asthma ( 30929738 32296059) Asthma (childhood onset) ( 30929738) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Breast cancer ( 29059683) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Chronic lymphocytic leukemia ( 24292274 28165464 23770605 26956414 18758461) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) Dehydroepiandrosterone sulphate levels ( 21533175) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Eosinophilic granulomatosis with polyangiitis ( 31719529) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Immature fraction of reticulocytes ( 27863252) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Primary sclerosing cholangitis ( 27992413 21151127) Prostate cancer ( 29892016) Prostate cancer (advanced) ( 29892016) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494 27863252) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 33272962) Triglyceride levels ( 32203549) Type 2 diabetes ( 30054458 28869590) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Urinary albumin-to-creatinine ratio ( 32600054) Vitiligo ( 27723757) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Apolipoprotein A1 levels ( 32203549) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) HDL cholesterol ( 30275531) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Multiple sclerosis ( 21654844) Thyrotoxic periodic paralysis ( 33105104)
Interacting Genes		31 interacting genes: AKT1 APP ATP6V1G1 AURKB BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L2 BTK CDK1 DTX2 DYNLL1 FEM1C FGL1 GTF2I MAGEA11 MAPK10 MAPK8 MAPK9 MCL1 MEX3D MKRN3 PEX19 RACK1 RIOK3 SMARCB1 TRIM2 USHBP1 VDAC1 YWHAB	31 interacting genes: BCL2L11 CDK20 CIB3 COG3 CSNK1E DTNBP1 GJB5 KCTD7 LRRC8E MNAT1 MYO5A OTUB2 SIRPA TNFAIP3 TNIK TRIM8 UBAC1 UBE2C UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2F UBE2G1 UBE2H UBE2K UBE2N UBE2U UBE2W
Entrez ID		10018	23321
HPRD ID		04828	10279
Ensembl ID		ENSG00000153094	ENSG00000109654
Uniprot IDs		A0A0C4DH20 E9PAM9 H7BZE5 O43521	A0A0J9YW02 A0A6Q8PF74 A0A6Q8PG16 A0A6Q8PGG4 A0A6Q8PHP4 Q9C040
PDB IDs		1F95 2K7W 2NL9 2V6Q 2VM6 2WH6 2YQ6 2YQ7 3D7V 3FDL 3IO8 3IO9 3KJ0 3KJ1 3KJ2 4A1U 4A1W 4B4S 4D2M 4QVF 4UF3 4YJ4 4ZIE 4ZIF 4ZIH 5AGW 5AGX 5C3G 5VWV 5VWW 5VWX 5VWY 5VWZ 5VX0 5VX2 5VX3 5WOS 6QFI 6RJP 6TQQ 6UA3 6UAB 6VBX 6X8O 8T5E	7B2R 7B96 7QRV 7ZJ3 8A38 8AMS
Enriched GO Terms of Interacting Partners?		Release Of Cytochrome C From Mitochondria Apoptotic Mitochondrial Changes Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Channel Activity BH3 Domain Binding Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Bcl-2 Family Protein Complex Positive Regulation Of Apoptotic Process Apoptotic Process Positive Regulation Of Programmed Cell Death Programmed Cell Death Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage JUN Kinase Activity Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Extrinsic Apoptotic Signaling Pathway Mitochondrial Outer Membrane Apoptotic Signaling Pathway Fc-epsilon Receptor Signaling Pathway Mitochondrion Organization Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Response To Radiation Regulation Of Intrinsic Apoptotic Signaling Pathway Intracellular Signal Transduction Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Response To Light Stimulus Post-translational Protein Modification Mitochondrion Protein Modification Process Cytosol Protein Serine Kinase Activity MAP Kinase Activity Fc Receptor Signaling Pathway Regulation Of Autophagy Regulation Of Immune Response Negative Regulation Of Anoikis Regulation Of Apoptotic Signaling Pathway Regulation Of Neuron Apoptotic Process Regulation Of B Cell Apoptotic Process Protein Serine/threonine Kinase Activity Negative Regulation Of Metabolic Process Peptidyl-threonine Phosphorylation Immune Response-regulating Signaling Pathway DNA Damage Response Dendritic Cell Apoptotic Process Response To Reactive Oxygen Species Immune Response-regulating Cell Surface Receptor Signaling Pathway	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein K48-linked Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein Modification Process Protein K11-linked Ubiquitination ATP Binding Transferase Activity Nucleotide Binding Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Metabolic Process Protein Monoubiquitination Proteolysis Involved In Protein Catabolic Process Protein K63-linked Ubiquitination Proteolysis Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Proteasomal Protein Catabolic Process Ubiquitin-like Protein Transferase Activity Protein Catabolic Process ISG15 Transferase Activity Ubiquitin Ligase Complex ISG15-protein Conjugation Cellular Response To Stress DNA Damage Response Free Ubiquitin Chain Polymerization Catabolic Process Cytosol Protein K11-linked Deubiquitination Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway DNA Repair Filopodium Tip Protein Binding Ubiquitin Binding Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Protein K6-linked Ubiquitination Regulation Of Lipopolysaccharide-mediated Signaling Pathway B Cell Homeostasis DNA Metabolic Process Nucleus Tolerance Induction To Lipopolysaccharide Negative Regulation Of Toll-like Receptor 5 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Defense Response To Virus
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