AKR1C3 and HUNK

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		AKR1C3	HUNK
Description		aldo-keto reductase family 1 member C3	hormonally up-regulated Neu-associated kinase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Exosome	Cytoplasm
	Molecular Function	Retinal Dehydrogenase (NAD+) Activity Aldose Reductase (NADPH) Activity Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity All-trans-retinol Dehydrogenase (NAD+) Activity Protein Binding Alcohol Dehydrogenase (NADP+) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Bile Acid Binding Prostaglandin H2 Endoperoxidase Reductase Activity Prostaglandin D2 11-ketoreductase Activity Geranylgeranyl Reductase Activity Ketoreductase Activity Prostaglandin F Synthase Activity 15-hydroxyprostaglandin-D Dehydrogenase (NADP+) Activity Androsterone Dehydrogenase [NAD(P)+] Activity 5-alpha-androstane-3-beta,17-beta-diol Dehydrogenase (NADP+) Activity Testosterone Dehydrogenase (NAD+) Activity Androstan-3-alpha,17-beta-diol Dehydrogenase (NAD+) Activity Testosterone Dehydrogenase (NADP+) Activity Ketosteroid Monooxygenase Activity Delta4-3-oxosteroid 5beta-reductase Activity All-trans-retinol Dehydrogenase (NADP+) Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Retinoid Metabolic Process Alcohol Metabolic Process Lipid Metabolic Process Prostaglandin Metabolic Process G Protein-coupled Receptor Signaling Pathway Response To Nutrient Steroid Metabolic Process Positive Regulation Of Cell Population Proliferation Male Gonad Development Cellular Response To Starvation Farnesol Catabolic Process Keratinocyte Differentiation Monocarboxylic Acid Metabolic Process Hormone Metabolic Process Progesterone Metabolic Process Retinol Metabolic Process Retinal Metabolic Process Macromolecule Metabolic Process Daunorubicin Metabolic Process Doxorubicin Metabolic Process Prostanoid Biosynthetic Process Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Testosterone Biosynthetic Process Renal Absorption Cellular Response To Calcium Ion Cellular Response To Prostaglandin Stimulus Cellular Response To Corticosteroid Stimulus Cellular Response To Jasmonic Acid Stimulus Cellular Response To Prostaglandin D Stimulus Negative Regulation Of Retinoic Acid Biosynthetic Process Regulation Of Testosterone Biosynthetic Process Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process	Signal Transduction Intracellular Signal Transduction
Pathways		Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol Synthesis of Prostaglandins (PG) and Thromboxanes (TX) RA biosynthesis pathway Retinoid metabolism and transport
Drugs		NADH Indomethacin Androstenedione Rutin Prostaglandin D2 Flufenamic acid Nicotinamide adenine dinucleotide phosphate 3-carboxamido-1,3,5(10)-estratrien-17(R)-spiro-2'(5',5'-dimethyl-6'oxo)tetrahydropyran Olaparib
Diseases
GWAS		Epithelial ovarian cancer ( 31469419) Homeostasis model assessment of insulin resistance ( 33381925)	Crohn's disease ( 32581322) Joint damage progression in ACPA-negative rheumatoid arthritis ( 26077402) LDL cholesterol levels in HIV infection ( 33109212) Response to antipsychotic treatment in schizophrenia (reasoning) ( 21107309) Type 2 diabetes ( 21490949) Vitiligo ( 19890347)
Interacting Genes		7 interacting genes: ACIN1 HUNK LRIF1 MAGEA11 SIAH2 UBE2W ZHX1	92 interacting genes: AARS1 ABLIM1 ACTR8 AGAP3 AIP AKAP8L AKR1C3 ALAD ANXA7 APBA2 APPL2 ARMCX4 ASCL1 ASPA ATP5F1B BIN1 CAMK1 CCAR1 CLU COG2 COPA COPS4 COPS5 CTDSP1 CTR9 CXXC5 DIS3L DLAT DLST DNAJA1 DST EEF1A2 EFNA1 EIF4G1 EPRS1 GEN1 HEATR6 HEY1 IFT81 IFT88 KDM6A KIF3A LIMK1 LNX1 LRSAM1 LURAP1 MAGED1 MBD1 MCHR1 MGAT5B MOAP1 MORF4L2 MTMR10 MYCBP2 N4BP2L2 NAPA NEUROD2 OLR1 PICK1 PITHD1 PPP1R16B PTPRA PTPRD RAB5B RABEP1 SH2B1 SLC6A1 SMARCE1 SMYD2 SNRNP48 SNRNP70 SORBS1 SPARCL1 STMN1 STUB1 TAF1 TOMM6 TRIM68 TTC28 UBE2O USP8 VCPIP1 VPS35L VSNL1 ZBTB44 ZNF197 ZNF292 ZNF343 ZNF655 ZNF662 ZNF76 ZNF793
Entrez ID		8644	30811
HPRD ID		04911	09410
Ensembl ID		ENSG00000196139	ENSG00000142149
Uniprot IDs		A0A0A0MSS8 B4DKT3 P42330	P57058
PDB IDs		1RY0 1RY8 1S1P 1S1R 1S2A 1S2C 1XF0 1ZQ5 2F38 2FGB 3R43 3R58 3R6I 3R7M 3R8G 3R8H 3R94 3UFY 3UG8 3UGR 3UWE 4DBS 4DBU 4DBW 4DZ5 4FA3 4FAL 4FAM 4H7C 4HMN 4WDT 4WDU 4WDW 4WDX 4WRH 4XVD 4XVE 4YVV 4YVX 4ZFC 5HNT 5HNU 6A7B 6F2U 6F78 6GXK 7C7F 7C7G 7C7H 7WQM 7WQR 7WQS 7X3L 7X3M 7X3O 8BBS 8I0C 8JP1 8RB6 9FFD
Enriched GO Terms of Interacting Partners?			Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Metal Ion Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Protein Catabolic Process Regulation Of Cellular Component Organization Negative Regulation Of Protein Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Cellular Component Organization Positive Regulation Of Amyloid Fibril Formation Protein Modification By Small Protein Conjugation Regulation Of RNA Biosynthetic Process DeNEDDylase Activity
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