AKR1C3 and ACIN1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		AKR1C3	ACIN1
Gene Name		aldo-keto reductase family 1, member C3	apoptotic chromatin condensation inducer 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Cytoplasm Cytosol Extracellular Vesicular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Nuclear Speck Exon-exon Junction Complex ASAP Complex
	Molecular Function	Retinal Dehydrogenase Activity Alditol:NADP+ 1-oxidoreductase Activity Aldo-keto Reductase (NADP) Activity Retinol Dehydrogenase Activity Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Phenanthrene 9,10-monooxygenase Activity Dihydrotestosterone 17-beta-dehydrogenase Activity Prostaglandin D2 11-ketoreductase Activity Geranylgeranyl Reductase Activity Ketoreductase Activity Prostaglandin-F Synthase Activity 15-hydroxyprostaglandin-D Dehydrogenase (NADP+) Activity Androsterone Dehydrogenase Activity Testosterone Dehydrogenase (NAD+) Activity Testosterone 17-beta-dehydrogenase (NADP+) Activity Ketosteroid Monooxygenase Activity Trans-1,2-dihydrobenzene-1,2-diol Dehydrogenase Activity Indanol Dehydrogenase Activity Delta4-3-oxosteroid 5beta-reductase Activity	Nucleotide Binding Nucleic Acid Binding Protein Binding ATPase Activity Enzyme Binding Poly(A) RNA Binding
	Biological Process	Protein Import Into Nucleus, Translocation Retinoid Metabolic Process Prostaglandin Metabolic Process G-protein Coupled Receptor Signaling Pathway Response To Nutrient Phototransduction, Visible Light Steroid Metabolic Process Positive Regulation Of Cell Proliferation Male Gonad Development Cellular Response To Starvation Positive Regulation Of Cell Death Farnesol Catabolic Process Arachidonic Acid Metabolic Process Cyclooxygenase Pathway Keratinocyte Differentiation Cellular Response To Reactive Oxygen Species Progesterone Metabolic Process Retinal Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Small Molecule Metabolic Process Daunorubicin Metabolic Process Doxorubicin Metabolic Process Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Protein Kinase B Signaling Oxidation-reduction Process Testosterone Biosynthetic Process Renal Absorption Cellular Response To Cadmium Ion Cellular Response To Calcium Ion Cellular Response To Prostaglandin Stimulus Cellular Response To Corticosteroid Stimulus Cellular Response To Jasmonic Acid Stimulus Cellular Response To Prostaglandin D Stimulus Negative Regulation Of Retinoic Acid Biosynthetic Process Regulation Of Testosterone Biosynthetic Process Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process	MRNA Processing Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis RNA Splicing Erythrocyte Differentiation Apoptotic Chromosome Condensation Positive Regulation Of Apoptotic Process Positive Regulation Of Monocyte Differentiation Negative Regulation Of MRNA Splicing, Via Spliceosome
Pathways		Synthesis of bile acids and bile salts via 24-hydroxycholesterol Bile acid and bile salt metabolism Metabolism of lipids and lipoproteins Signaling by Retinoic Acid Diseases associated with visual transduction Arachidonic acid metabolism Synthesis of bile acids and bile salts via 27-hydroxycholesterol Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Visual phototransduction Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Synthesis of bile acids and bile salts RA biosynthesis pathway Retinoid metabolism and transport	Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase
Drugs		NADH Bimatoprost 4-Androstenedione Rutin (5e,13e)-9,15-Dihydroxy-11-Oxoprosta-5,13-Dien-1-Oicacid Flufenamic Acid 2\'-Monophosphoadenosine 5\'-Diphosphoribose 3-CARBOXAMIDO-1,3,5(10)-ESTRATRIEN-17(R)-SPIRO-2\'(5\',5\'-DIMETHYL-6\'OXO)TETRAHYDROPYRAN
Diseases
GWAS
Protein-Protein Interactions		5 interactors: ACIN1 LRIF1 MAGEA11 UBE2W ZHX1	11 interactors: ABCF3 AKR1C3 BTBD10 CASP3 CSNK2A1 KLHL26 PAFAH1B2 PCBD1 RNPS1 SRPK2 YWHAG
Entrez ID		8644	22985
HPRD ID		04911	05191
Ensembl ID		ENSG00000196139	ENSG00000100813
Uniprot IDs		B4DKT3 P42330 S4R3Z2	B4DQZ7 Q9UKV3
PDB IDs		1RY0 1RY8 1S1P 1S1R 1S2A 1S2C 1XF0 1ZQ5 2F38 2FGB 3R43 3R58 3R6I 3R7M 3R8G 3R8H 3R94 3UFY 3UG8 3UGR 3UWE 4DBS 4DBU 4DBW 4DZ5 4FA3 4FAL 4FAM 4H7C
Enriched GO Terms of Interacting Partners?		Apoptotic Chromosome Condensation Positive Regulation Of Monocyte Differentiation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Monocyte Differentiation Cellular Response To Misfolded Protein Misfolded Or Incompletely Synthesized Protein Catabolic Process Response To Misfolded Protein Negative Regulation Of MRNA Splicing, Via Spliceosome Nitrogen Compound Metabolic Process Negative Regulation Of RNA Splicing Protein K11-linked Ubiquitination Apoptotic Nuclear Changes Protein Monoubiquitination	Regulation Of Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Regulation Of Neuron Death Regulation Of Metabolic Process Positive Regulation Of Neuron Apoptotic Process Regulation Of MRNA Splicing, Via Spliceosome Nuclear Speck Organization Negative Regulation Of Retinoic Acid Biosynthetic Process Catabolic Process Positive Regulation Of Neuron Death Regulation Of MRNA Processing Keratinocyte Differentiation Aromatic Compound Catabolic Process Regulation Of RNA Splicing Regulation Of Testosterone Biosynthetic Process Farnesol Catabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Isoprenoid Metabolic Process Sesquiterpenoid Metabolic Process Negative Regulation Of Protein Serine/threonine Kinase Activity Epidermal Cell Differentiation Cellular Response To Jasmonic Acid Stimulus Regulation Of Cell Proliferation Positive Regulation Of Cellular Metabolic Process Cellular Response To Prostaglandin D Stimulus Intrinsic Apoptotic Signaling Pathway Glial Cell Apoptotic Process Cellular Response To Oxidative Stress Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process System Development Regulation Of Apoptotic DNA Fragmentation Daunorubicin Metabolic Process Doxorubicin Metabolic Process Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Protein Kinase Activity Testosterone Biosynthetic Process Negative Regulation Of Catalytic Activity Skin Development Negative Regulation Of Cellular Protein Metabolic Process Tetrahydrobiopterin Biosynthetic Process MRNA Splicing, Via Spliceosome Negative Regulation Of Kinase Activity Positive Regulation Of Cell Proliferation RNA Splicing, Via Transesterification Reactions Regulation Of Neuron Apoptotic Process Lipid Catabolic Process
Tagcloud ?		20mug 5alpha abiraterone adrenal afforded androgen androgens androstanedione androstene armamentarium castration claim combinatorial dehydroepiandrosterone delta4 depot dhea dht dihydrotestosterone dione gonadal immunotherapies intratumoral ketoconazole mcrpc p450c17 persists prostatectomy taps
Tagcloud (Difference) ?		20mug 5alpha abiraterone adrenal afforded androgen androgens androstanedione androstene armamentarium castration claim combinatorial dehydroepiandrosterone delta4 depot dhea dht dihydrotestosterone dione gonadal immunotherapies intratumoral ketoconazole mcrpc p450c17 persists prostatectomy taps
Tagcloud (Intersection) ?