AKR1C3

Gene Name		aldo-keto reductase family 1, member C3
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Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Retinal Dehydrogenase Activity Alditol:NADP+ 1-oxidoreductase Activity Aldo-keto Reductase (NADP) Activity Retinol Dehydrogenase Activity Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Phenanthrene 9,10-monooxygenase Activity Dihydrotestosterone 17-beta-dehydrogenase Activity Prostaglandin D2 11-ketoreductase Activity Geranylgeranyl Reductase Activity Ketoreductase Activity Prostaglandin-F Synthase Activity 15-hydroxyprostaglandin-D Dehydrogenase (NADP+) Activity Androsterone Dehydrogenase Activity Testosterone Dehydrogenase (NAD+) Activity Testosterone 17-beta-dehydrogenase (NADP+) Activity Ketosteroid Monooxygenase Activity Trans-1,2-dihydrobenzene-1,2-diol Dehydrogenase Activity Indanol Dehydrogenase Activity Delta4-3-oxosteroid 5beta-reductase Activity
	Biological Process	Protein Import Into Nucleus, Translocation Retinoid Metabolic Process Prostaglandin Metabolic Process G-protein Coupled Receptor Signaling Pathway Response To Nutrient Phototransduction, Visible Light Steroid Metabolic Process Positive Regulation Of Cell Proliferation Male Gonad Development Cellular Response To Starvation Positive Regulation Of Cell Death Farnesol Catabolic Process Arachidonic Acid Metabolic Process Cyclooxygenase Pathway Keratinocyte Differentiation Cellular Response To Reactive Oxygen Species Progesterone Metabolic Process Retinal Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Small Molecule Metabolic Process Daunorubicin Metabolic Process Doxorubicin Metabolic Process Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Protein Kinase B Signaling Oxidation-reduction Process Testosterone Biosynthetic Process Renal Absorption Cellular Response To Cadmium Ion Cellular Response To Calcium Ion Cellular Response To Prostaglandin Stimulus Cellular Response To Corticosteroid Stimulus Cellular Response To Jasmonic Acid Stimulus Cellular Response To Prostaglandin D Stimulus Negative Regulation Of Retinoic Acid Biosynthetic Process Regulation Of Testosterone Biosynthetic Process Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Synthesis of bile acids and bile salts via 24-hydroxycholesterol Bile acid and bile salt metabolism Metabolism of lipids and lipoproteins Signaling by Retinoic Acid Diseases associated with visual transduction Arachidonic acid metabolism Synthesis of bile acids and bile salts via 27-hydroxycholesterol Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Visual phototransduction Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Synthesis of bile acids and bile salts RA biosynthesis pathway Retinoid metabolism and transport
Drugs		NADH Bimatoprost 4-Androstenedione Rutin (5e,13e)-9,15-Dihydroxy-11-Oxoprosta-5,13-Dien-1-Oicacid Flufenamic Acid 2\'-Monophosphoadenosine 5\'-Diphosphoribose 3-CARBOXAMIDO-1,3,5(10)-ESTRATRIEN-17(R)-SPIRO-2\'(5\',5\'-DIMETHYL-6\'OXO)TETRAHYDROPYRAN
Diseases
GWAS
Protein-protein Interactions		5 interactors: ACIN1 LRIF1 MAGEA11 UBE2W ZHX1
Entrez ID		8644
HPRD ID		04911
Ensembl ID		ENSG00000196139
Uniprot IDs		B4DKT3 P42330 S4R3Z2
PDB IDs		1RY0 1RY8 1S1P 1S1R 1S2A 1S2C 1XF0 1ZQ5 2F38 2FGB 3R43 3R58 3R6I 3R7M 3R8G 3R8H 3R94 3UFY 3UG8 3UGR 3UWE 4DBS 4DBU 4DBW 4DZ5 4FA3 4FAL 4FAM 4H7C
Enriched GO Terms of Interacting Partners?		Apoptotic Chromosome Condensation Positive Regulation Of Monocyte Differentiation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Monocyte Differentiation Cellular Response To Misfolded Protein Misfolded Or Incompletely Synthesized Protein Catabolic Process Response To Misfolded Protein Negative Regulation Of MRNA Splicing, Via Spliceosome Nitrogen Compound Metabolic Process Negative Regulation Of RNA Splicing Protein K11-linked Ubiquitination Apoptotic Nuclear Changes Protein Monoubiquitination
Tagcloud ?		20mug 5alpha abiraterone adrenal afforded androgen androgens androstanedione androstene armamentarium castration claim combinatorial dehydroepiandrosterone delta4 depot dhea dht dihydrotestosterone dione gonadal immunotherapies intratumoral ketoconazole mcrpc p450c17 persists prostatectomy taps