AKR1C3 and MAGEA11

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		AKR1C3	MAGEA11
Gene Name		aldo-keto reductase family 1, member C3	melanoma antigen family A, 11
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Cytoplasm Cytosol Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Retinal Dehydrogenase Activity Alditol:NADP+ 1-oxidoreductase Activity Aldo-keto Reductase (NADP) Activity Retinol Dehydrogenase Activity Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Phenanthrene 9,10-monooxygenase Activity Dihydrotestosterone 17-beta-dehydrogenase Activity Prostaglandin D2 11-ketoreductase Activity Geranylgeranyl Reductase Activity Ketoreductase Activity Prostaglandin-F Synthase Activity 15-hydroxyprostaglandin-D Dehydrogenase (NADP+) Activity Androsterone Dehydrogenase Activity Testosterone Dehydrogenase (NAD+) Activity Testosterone 17-beta-dehydrogenase (NADP+) Activity Ketosteroid Monooxygenase Activity Trans-1,2-dihydrobenzene-1,2-diol Dehydrogenase Activity Indanol Dehydrogenase Activity Delta4-3-oxosteroid 5beta-reductase Activity	Protein Binding
	Biological Process	Protein Import Into Nucleus, Translocation Retinoid Metabolic Process Prostaglandin Metabolic Process G-protein Coupled Receptor Signaling Pathway Response To Nutrient Phototransduction, Visible Light Steroid Metabolic Process Positive Regulation Of Cell Proliferation Male Gonad Development Cellular Response To Starvation Positive Regulation Of Cell Death Farnesol Catabolic Process Arachidonic Acid Metabolic Process Cyclooxygenase Pathway Keratinocyte Differentiation Cellular Response To Reactive Oxygen Species Progesterone Metabolic Process Retinal Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Small Molecule Metabolic Process Daunorubicin Metabolic Process Doxorubicin Metabolic Process Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Protein Kinase B Signaling Oxidation-reduction Process Testosterone Biosynthetic Process Renal Absorption Cellular Response To Cadmium Ion Cellular Response To Calcium Ion Cellular Response To Prostaglandin Stimulus Cellular Response To Corticosteroid Stimulus Cellular Response To Jasmonic Acid Stimulus Cellular Response To Prostaglandin D Stimulus Negative Regulation Of Retinoic Acid Biosynthetic Process Regulation Of Testosterone Biosynthetic Process Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Synthesis of bile acids and bile salts via 24-hydroxycholesterol Bile acid and bile salt metabolism Metabolism of lipids and lipoproteins Signaling by Retinoic Acid Diseases associated with visual transduction Arachidonic acid metabolism Synthesis of bile acids and bile salts via 27-hydroxycholesterol Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Visual phototransduction Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Synthesis of bile acids and bile salts RA biosynthesis pathway Retinoid metabolism and transport
Drugs		NADH Bimatoprost 4-Androstenedione Rutin (5e,13e)-9,15-Dihydroxy-11-Oxoprosta-5,13-Dien-1-Oicacid Flufenamic Acid 2\'-Monophosphoadenosine 5\'-Diphosphoribose 3-CARBOXAMIDO-1,3,5(10)-ESTRATRIEN-17(R)-SPIRO-2\'(5\',5\'-DIMETHYL-6\'OXO)TETRAHYDROPYRAN
Diseases
GWAS
Protein-Protein Interactions		5 interactors: ACIN1 LRIF1 MAGEA11 UBE2W ZHX1	86 interactors: ACMSD ACTN1 AKR1C3 ALDH5A1 AR ARHGAP29 BCL2L11 BEX2 BIRC2 C18orf54 CCDC14 CCDC146 CCDC185 CDC20B CDKN2B CEP76 CLUAP1 COX7A2L CSNK2A1 DIEXF DNAJC10 DOCK10 ENOX2 EWSR1 FAM156A GNPDA1 HOXB5 IL11 IL6ST ILF3 JADE3 KIAA0408 LNX1 MAPK3 MCRS1 MED28 MGME1 MLF1 MTA1 MXD3 MYOZ1 NCOA2 NDEL1 NDUFAF1 NDUFB9 NIF3L1 NOL4 NOS3 NSUN4 OTUB2 PCBD2 PDE4B PHYH PIN4 PNKD PNKP POLR1D PRDX3 PRKRIP1 PSMF1 RADIL RBM23 SH2D4A SNX20 SNX7 STAR TCEA2 TCEANC TCF25 TEX37 THEM5 TMEM123 TPM3 TRIM27 TRIM51 TRMT1 TXN2 UBE2D4 USP20 VTA1 WDYHV1 WTAP ZBTB16 ZCCHC12 ZNF655 ZSWIM2
Entrez ID		8644	4110
HPRD ID		04911	02281
Ensembl ID		ENSG00000196139	ENSG00000185247
Uniprot IDs		B4DKT3 P42330 S4R3Z2	G5E962 P43364
PDB IDs		1RY0 1RY8 1S1P 1S1R 1S2A 1S2C 1XF0 1ZQ5 2F38 2FGB 3R43 3R58 3R6I 3R7M 3R8G 3R8H 3R94 3UFY 3UG8 3UGR 3UWE 4DBS 4DBU 4DBW 4DZ5 4FA3 4FAL 4FAM 4H7C
Enriched GO Terms of Interacting Partners?		Apoptotic Chromosome Condensation Positive Regulation Of Monocyte Differentiation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Monocyte Differentiation Cellular Response To Misfolded Protein Misfolded Or Incompletely Synthesized Protein Catabolic Process Response To Misfolded Protein Negative Regulation Of MRNA Splicing, Via Spliceosome Nitrogen Compound Metabolic Process Negative Regulation Of RNA Splicing Protein K11-linked Ubiquitination Apoptotic Nuclear Changes Protein Monoubiquitination	Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Metabolic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Metabolic Process Cellular Process Positive Regulation Of Metabolic Process Gene Expression Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Catabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Apoptotic Process Metabolic Process Protein Polyubiquitination Negative Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Testosterone Biosynthetic Process Regulation Of Cell Death Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Protein Metabolic Process Rhythmic Process Cell Death Response To Lipopolysaccharide Death Negative Regulation Of Protein Metabolic Process Respiratory Electron Transport Chain Response To Molecule Of Bacterial Origin Regulation Of Cell Cycle Electron Transport Chain Oxidation-reduction Process Negative Regulation Of Catalytic Activity RNA Methylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Apoptotic Process Reproductive Structure Development Positive Regulation Of Gene Expression Reproductive System Development Negative Regulation Of Mitotic Cell Cycle Phase Transition Programmed Cell Death
Tagcloud ?		20mug 5alpha abiraterone adrenal afforded androgen androgens androstanedione androstene armamentarium castration claim combinatorial dehydroepiandrosterone delta4 depot dhea dht dihydrotestosterone dione gonadal immunotherapies intratumoral ketoconazole mcrpc p450c17 persists prostatectomy taps
Tagcloud (Difference) ?		20mug 5alpha abiraterone adrenal afforded androgen androgens androstanedione androstene armamentarium castration claim combinatorial dehydroepiandrosterone delta4 depot dhea dht dihydrotestosterone dione gonadal immunotherapies intratumoral ketoconazole mcrpc p450c17 persists prostatectomy taps
Tagcloud (Intersection) ?