HDAC4 and HDAC9

  • Number of citations of the paper that reports this interaction (PubMedID 12590135)
  • 0
  • Data Source:
  • BioGRID (pull down)
  • HPRD (in vitro, in vivo)

HDAC4

HDAC9

Description histone deacetylase 4 histone deacetylase 9
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653)
  • Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals ( 22959728)
  • Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885)
  • Blond vs. brown/black hair color ( 30531825)
  • Body size at age 10 ( 32376654)
  • Chronotype ( 30696823)
  • CV-A6-associated hand, foot, and mouth disease (severe vs mild) ( 32634583)
  • Diastolic blood pressure ( 30224653 30487518)
  • Estimated glomerular filtration rate after 5 years in renal transplantation (recipient effect) ( 30920136)
  • Heel bone mineral density ( 30598549)
  • Intra-individual response time variability (selective attention) ( 30287865)
  • Male-pattern baldness ( 22693459)
  • Mean arterial pressure ( 30487518 29403010)
  • Nevus count ( 30429480)
  • Nevus count or cutaneous melanoma ( 30429480)
  • Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507)
  • Perioperative myocardial infarction in coronary artery bypass surgery ( 25948407)
  • Pulmonary function ( 21946350)
  • Pulmonary function (smoking interaction) ( 23284291)
  • Systolic blood pressure ( 30487518)
  • Abdominal aortic calcification levels ( 31659325)
  • Appendicular lean mass ( 33097823)
  • Brain morphology (MOSTest) ( 32665545)
  • Cerebral amyloid angiopathy ( 25188341)
  • Colorectal cancer x fine particulate matter exposure levels interaction ( 33338681)
  • Coronary artery disease ( 32469254 26343387 33020668)
  • Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975)
  • Coronary artery disease or large artery stroke ( 24262325)
  • Cortical surface area (visual PC2) ( 32198502)
  • Cortical volume ( 32963231)
  • Depressive symptom (fatigue) (ordinal trait) ( 31530331)
  • Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383)
  • Fasting blood glucose ( 31217584)
  • Fasting glucose ( 34074324)
  • Height ( 31562340)
  • Iris color (b* coordinate) ( 30895295)
  • Ischemic stroke ( 26708676)
  • Ischemic stroke (large artery atherosclerosis) ( 26708676)
  • Large artery stroke ( 28265093 24262325)
  • Large artery stroke (CCS and TOAST classification) ( 32047268)
  • Large artery stroke (CCS or TOAST classification) ( 32047268)
  • Large artery stroke (CCSp classification)j ( 32047268)
  • Large artery stroke (TOAST classification) ( 32047268)
  • Late-onset Alzheimer's disease ( 27770636)
  • Loneliness ( 27629369)
  • Male-pattern baldness ( 27182965 22693459 28196072)
  • Mean corpuscular hemoglobin concentration ( 32888494)
  • Metabolite levels ( 31628463)
  • Moderate-to-late spontaneous preterm birth ( 31194736)
  • Monobrow ( 27182965)
  • Moyamoya disease ( 29273593)
  • Myocardial infarction ( 33532862)
  • Neuritic plaques or cerebral amyloid angiopathy (pleiotropy) ( 29458411)
  • Neuritic plaques or neurofibrillary tangles or cerebral amyloid angiopathy (pleiotropy) ( 29458411)
  • Neurofibrillary tangles or cerebral amyloid angiopathy (pleiotropy) ( 29458411)
  • Night sleep phenotypes ( 27126917)
  • Obesity-related traits ( 23251661)
  • Osteoarthritis (hip) ( 30374069)
  • Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912)
  • Peripheral artery disease ( 31285632 26488411)
  • Platelet count ( 32888494)
  • Platelet distribution width ( 32888494)
  • Plateletcrit ( 27863252 32888494)
  • Pulse pressure ( 29403010 28739976 26390057 27841878 30487518)
  • Reading disability ( 32108986)
  • Reasoning ( 29907492)
  • Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482)
  • Response to lithium treatment in bipolar disorder (continuous phenotype) ( 26806518)
  • Resting-state electroencephalogram vigilance ( 29703947)
  • Retinopathy in non-diabetics ( 23393555)
  • Stroke ( 26089329 22306652)
  • Stroke (ischemic) ( 23041239)
  • Subcortical volume (MOSTest) ( 32665545)
  • Systemic juvenile idiopathic arthritis ( 27927641)
  • Systolic blood pressure ( 27841878 30487518)
  • Type 2 diabetes (age of onset) ( 28060188)
  • Ulcerative colitis ( 20848476)
  • Zinc levels ( 26025379)
Interacting Genes 123 interacting genes: ACTA1 ANKRA2 ANKRD11 APP AR ASB15 ATF3 ATRX BCL6 BCOR BEGAIN BICD2 BLZF1 BORCS8-MEF2B BRMS1 CACNA1C CADPS CALCOCO2 CAMK4 CBX5 CCDC125 CCDC136 CCNDBP1 CDKN1A CDPF1 CDR2 CDR2L CEBPD CEP70 CIITA CSRP3 CTBP1 DYDC1 EFEMP2 EFHC2 ESR1 FCHSD2 FSD2 GATA1 GCM1 GOLGA2 GOLGA6L9 GRIPAP1 GSK3B HAP1 HDAC3 HDAC7 HDAC9 HNF4A HOOK2 HSF2BP IFRD1 IKZF2 INCA1 JDP2 KRT27 KRT31 KRT33B KRT34 KRT35 KRT38 KRT40 LCOR LDOC1 LZTR1 MAP1S MAPK1 MAPK3 MECOM MEF2A MEF2B MEF2C MEF2D MEGF10 MID2 MIF4GD MTUS2 NACC1 NCOR2 NFKB2 NFKBID NFKBIE NPPB NR1H2 NR2C1 NR2C2 PICK1 PNMA1 PPARD PPARG PTOV1 PTPA RANBP2 RARA RBBP4 REV3L RFXANK RINT1 RUNX2 RUNX3 RUVBL2 RXRA SMAD3 SRF SS18L1 SSX2IP SUMO1 SUMO2 SYK TFIP11 TLE5 TNFRSF14 TRIB3 TRIM27 TSGA10 UBE2I VPS52 YWHAE YWHAG YWHAZ ZBTB16 ZMYND12 ZNF354A 30 interacting genes: ANKRA2 BCL6 CBX5 CTBP1 ESR1 ETV6 H3C15 H4C16 HDAC1 HDAC3 HDAC4 JUN MAML1 MAPK10 MAPK8 MAPK9 MEF2A MEF2C NCOR1 NRIP1 PKD1 SIN3A SIN3B SUMO1 SUMO2 SYK TRIM29 USF1 YWHAZ ZBTB16
Entrez ID 9759 9734
HPRD ID 05610 05944
Ensembl ID ENSG00000068024 ENSG00000048052
Uniprot IDs A0A7I2SVS4 B7Z8G5 P56524 A0A7P0T8F4 A0A7P0TAB5 A0A9L9PXL9 B7Z3P7 Q9UKV0
PDB IDs 2H8N 2O94 2VQJ 2VQM 2VQO 2VQQ 2VQV 2VQW 3UXG 3UZD 3V31 4CBT 4CBY 5A2S 5ZOO 5ZOP 6FYZ 7XUZ 8PDE 8Q9N 8Q9R
Enriched GO Terms of Interacting Partners?
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