HDAC4 and MEF2A

Number of citations of the paper that reports this interaction (PMID 10487761)
145

Data Source:
HPRD (in vivo, in vitro)

		HDAC4	MEF2A
Gene Name		histone deacetylase 4	myocyte enhancer factor 2A
Image
Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Transcriptional Repressor Complex Z Disc Neuromuscular Junction A Band Actomyosin	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm
	Molecular Function	Core Promoter Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Protein Kinase Binding Potassium Ion Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Activating Transcription Factor Binding Histone Deacetylase Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) Repressing Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Factor Binding RNA Polymerase II Transcription Coactivator Activity Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Kinase Binding Activating Transcription Factor Binding Histone Acetyltransferase Binding Histone Deacetylase Binding Sequence-specific DNA Binding SMAD Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Osteoblast Development Chromatin Remodeling Transcription, DNA-templated Inflammatory Response Nervous System Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Negative Regulation Of Myotube Differentiation Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Response To Denervation Involved In Regulation Of Muscle Adaptation Cardiac Muscle Hypertrophy In Response To Stress Histone Deacetylation B Cell Differentiation Positive Regulation Of Protein Sumoylation Peptidyl-lysine Deacetylation Regulation Of Gene Expression, Epigenetic B Cell Activation Response To Drug Regulation Of Protein Binding Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Glycolytic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Histone H3-K9 Modification Response To Interleukin-1 Histone H3 Deacetylation Histone H4 Deacetylation	Mitochondrial Genome Maintenance Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Apoptotic Process Heart Development Muscle Organ Development Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Muscle Cell Differentiation Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Mitochondrion Distribution Dendrite Morphogenesis Positive Regulation Of Muscle Cell Differentiation Stress-activated MAPK Cascade Ventricular Cardiac Myofibril Assembly Cardiac Conduction ERK5 Cascade Cellular Response To Calcium Ion
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer	Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets Innate Immune System Signalling by NGF CDO in myogenesis TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Myogenesis Toll Like Receptor 3 (TLR3) Cascade ERK/MAPK targets Toll Like Receptor 4 (TLR4) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Male-pattern baldness ( 22693459) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291)
Protein-Protein Interactions		89 interactors: ACTA1 ANKRA2 ANKRD11 APP AR ATF3 ATRX BCL6 BCOR BRMS1 CACNA1C CAMK2D CAMK4 CBX5 CCDC136 CDKN1A CDR2 CEBPD CIITA CSRP3 CTBP1 EFEMP2 ESR1 GATA1 GCM1 GNB1 GOLGA2 GSK3B HDAC3 HDAC7 HDAC9 HNF4A IFRD1 IKZF2 JDP2 KRT31 KRT38 KRT40 LCOR LDOC1 LZTR1 MAP1S MAPK1 MAPK3 MECOM MEF2A MEF2B MEF2C MEF2D MEGF10 MIF4GD MTUS2 NACC1 NCOR2 NFKB2 NFKBIE NPPB NR1H2 NR2C1 NR2C2 NUP155 PNMA1 PPARD PPARG PPP2R4 RANBP2 RARA RBBP4 REV3L RFXANK RINT1 RUNX2 RUNX3 RUVBL2 RXRA SMAD3 SRF SS18L1 SUMO1 SUMO2 SYK TNFRSF14 UBE2I YWHAE YWHAG YWHAQ YWHAZ ZBTB16 ZNF354A	26 interactors: ACTN4 ASCL1 CASP3 CASP7 CDK5 DDB1 EP300 ERBB2IP HAND1 HDAC4 HDAC5 HDAC7 HDAC9 MAPK14 MAPK7 MEF2D MYOD1 MYOG NDUFB9 PHB2 SMAD2 SMAD4 SUMO1 TEAD1 THRA VGLL4
Entrez ID		9759	4205
HPRD ID		05610	02807
Ensembl ID		ENSG00000068024	ENSG00000068305
Uniprot IDs		B7Z8G5 P56524 Q86YH7	Q02078
PDB IDs		2H8N 2O94 2VQJ 2VQM 2VQO 2VQQ 2VQV 2VQW 3UXG 3UZD 3V31	1C7U 1EGW 1LEW 3KOV 3MU6 3P57
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Organ Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Organic Substance Cellular Macromolecule Biosynthetic Process Response To Organic Substance Cellular Nitrogen Compound Metabolic Process Regulation Of Cellular Process Biosynthetic Process Nitrogen Compound Metabolic Process Anatomical Structure Development System Development Cell Differentiation Developmental Process Transcription Initiation From RNA Polymerase II Promoter Multicellular Organismal Development DNA-templated Transcription, Initiation Response To Hormone Cellular Response To Hormone Stimulus Cellular Response To Lipid Regulation Of Cellular Localization	Regulation Of Myotube Differentiation Regulation Of Skeletal Muscle Fiber Development Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Muscle Cell Differentiation Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Organ Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Skeletal Muscle Tissue Development Heart Development Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Binding Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Tissue Development Response To Organic Substance Regulation Of Cell Development Cardiovascular System Development Nitrogen Compound Metabolic Process Regulation Of Gene Expression RNA Metabolic Process Regulation Of Cell Differentiation Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of Striated Muscle Tissue Development Response To Abiotic Stimulus Skeletal Muscle Tissue Development System Development Cellular Macromolecule Biosynthetic Process Developmental Process
Tagcloud ?		300mg 50mg ameliorated ameliorates ctgf dawley deacetylases dn emphasize fibrogenesis fibronectin fibrosis fibrotic hdacs histology icam microscope migraine myofibroblast nephropathy profibrotic renoprotective route sma sprague stz valproic vpa	blastula distinguished ectoderm ectopic embryo explants lie mef2d mesoderm myf5 myod myogenesis myogenic myosin neither pole precedes presumptive reciprocal rsrf skeletal sl1 sl2 somitic tailbud xenopus xmlc2 zygotic
Tagcloud (Difference) ?		300mg 50mg ameliorated ameliorates ctgf dawley deacetylases dn emphasize fibrogenesis fibronectin fibrosis fibrotic hdacs histology icam microscope migraine myofibroblast nephropathy profibrotic renoprotective route sma sprague stz valproic vpa	blastula distinguished ectoderm ectopic embryo explants lie mef2d mesoderm myf5 myod myogenesis myogenic myosin neither pole precedes presumptive reciprocal rsrf skeletal sl1 sl2 somitic tailbud xenopus xmlc2 zygotic
Tagcloud (Intersection) ?