HDAC4

Gene Name		histone deacetylase 4
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Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Transcriptional Repressor Complex Z Disc Neuromuscular Junction A Band Actomyosin
	Molecular Function	Core Promoter Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Protein Kinase Binding Potassium Ion Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Activating Transcription Factor Binding Histone Deacetylase Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) Repressing Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Osteoblast Development Chromatin Remodeling Transcription, DNA-templated Inflammatory Response Nervous System Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Negative Regulation Of Myotube Differentiation Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Response To Denervation Involved In Regulation Of Muscle Adaptation Cardiac Muscle Hypertrophy In Response To Stress Histone Deacetylation B Cell Differentiation Positive Regulation Of Protein Sumoylation Peptidyl-lysine Deacetylation Regulation Of Gene Expression, Epigenetic B Cell Activation Response To Drug Regulation Of Protein Binding Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Glycolytic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Histone H3-K9 Modification Response To Interleukin-1 Histone H3 Deacetylation Histone H4 Deacetylation
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Male-pattern baldness ( 22693459) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291)
Protein-protein Interactions		89 interactors: ACTA1 ANKRA2 ANKRD11 APP AR ATF3 ATRX BCL6 BCOR BRMS1 CACNA1C CAMK2D CAMK4 CBX5 CCDC136 CDKN1A CDR2 CEBPD CIITA CSRP3 CTBP1 EFEMP2 ESR1 GATA1 GCM1 GNB1 GOLGA2 GSK3B HDAC3 HDAC7 HDAC9 HNF4A IFRD1 IKZF2 JDP2 KRT31 KRT38 KRT40 LCOR LDOC1 LZTR1 MAP1S MAPK1 MAPK3 MECOM MEF2A MEF2B MEF2C MEF2D MEGF10 MIF4GD MTUS2 NACC1 NCOR2 NFKB2 NFKBIE NPPB NR1H2 NR2C1 NR2C2 NUP155 PNMA1 PPARD PPARG PPP2R4 RANBP2 RARA RBBP4 REV3L RFXANK RINT1 RUNX2 RUNX3 RUVBL2 RXRA SMAD3 SRF SS18L1 SUMO1 SUMO2 SYK TNFRSF14 UBE2I YWHAE YWHAG YWHAQ YWHAZ ZBTB16 ZNF354A
Entrez ID		9759
HPRD ID		05610
Ensembl ID		ENSG00000068024
Uniprot IDs		B7Z8G5 P56524 Q86YH7
PDB IDs		2H8N 2O94 2VQJ 2VQM 2VQO 2VQQ 2VQV 2VQW 3UXG 3UZD 3V31
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Organ Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Organic Substance Cellular Macromolecule Biosynthetic Process Response To Organic Substance Cellular Nitrogen Compound Metabolic Process Regulation Of Cellular Process Biosynthetic Process Nitrogen Compound Metabolic Process Anatomical Structure Development System Development Cell Differentiation Developmental Process Transcription Initiation From RNA Polymerase II Promoter Multicellular Organismal Development DNA-templated Transcription, Initiation Response To Hormone Cellular Response To Hormone Stimulus Cellular Response To Lipid Regulation Of Cellular Localization
Tagcloud ?		300mg 50mg ameliorated ameliorates ctgf dawley deacetylases dn emphasize fibrogenesis fibronectin fibrosis fibrotic hdacs histology icam microscope migraine myofibroblast nephropathy profibrotic renoprotective route sma sprague stz valproic vpa