CAV2 and RASA1

Number of citations of the paper that reports this interaction (PubMedID 15504032)
0

Data Source:
HPRD (in vitro)

		CAV2	RASA1
Description		caveolin 2	RAS p21 protein activator 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Acrosomal Membrane Caveolar Macromolecular Signaling Complex Nucleus Cytoplasm Golgi Apparatus Plasma Membrane Caveola Focal Adhesion Membrane Transport Vesicle Cytoplasmic Vesicle Protein-containing Complex Plasma Membrane Raft Membrane Raft Perinuclear Region Of Cytoplasm	Ruffle Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity D1 Dopamine Receptor Binding Heterotrimeric G-protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Molecular Adaptor Activity Scaffold Protein Binding	Phosphotyrosine Residue Binding GTPase Activity GTPase Activator Activity Signaling Receptor Binding Protein Binding Potassium Channel Inhibitor Activity Enzyme Binding GTPase Binding
	Biological Process	Endothelial Cell Proliferation Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Vesicle Fusion Mitochondrion Organization Endoplasmic Reticulum Organization Regulation Of Mitotic Nuclear Division Transforming Growth Factor Beta Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell Population Proliferation Insulin Receptor Signaling Pathway Skeletal Muscle Cell Proliferation Negative Regulation Of Skeletal Muscle Cell Proliferation Vesicle Organization Receptor-mediated Endocytosis Of Virus By Host Cell Viral Release From Host Cell Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Host-mediated Activation Of Viral Process Vesicle Docking Skeletal Muscle Fiber Development Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Dopamine Receptor Signaling Pathway Caveola Assembly Basement Membrane Organization	Mitotic Cytokinesis Angiogenesis Vasculogenesis Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Regulation Of Cell Shape Regulation Of Actin Filament Polymerization Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Ephrin Receptor Signaling Pathway Blood Vessel Morphogenesis System Development Regulation Of RNA Metabolic Process Regulation Of Intracellular Signal Transduction
Pathways		Extra-nuclear estrogen signaling	Downstream signal transduction EPHB-mediated forward signaling EPHB-mediated forward signaling VEGFR2 mediated cell proliferation Regulation of RAS by GAPs PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Drugs
Diseases			RASA1-related disorders, including: Parkes-Weber slndrome; Capillary malformation-arteriovenous malformation (CM-AVM); Arteriovenous fistula (AVF)
GWAS		Antipsychotic drug-induced weight gain in schizophrenia ( 31447353) Atrial fibrillation ( 33990960 30061737 29892015) Glaucoma ( 31959993 30054594) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 20835238 33627673 29891935 25173105) Heart rate increase in response to exercise ( 29497042) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Intraocular pressure ( 30054594 31959993 25173106 31798171 28073927 29785010 29617998) P wave duration ( 28794112) Pancreatic ductal adenocarcinoma ( 33975060) PR interval ( 29127183 30046033 32439900 25035420 20062060) Refractive error ( 32231278) TPE interval (resting) ( 32386560)	Chronotype ( 30696823) Macular thickness ( 30535121) Major depressive disorder ( 23377640) Openness ( 21173776) Prostate cancer aggressiveness ( 25939597) Type 2 diabetes ( 30297969)
Interacting Genes		13 interacting genes: CAV1 CSNK2A1 DNAJA1 DRD1 EGFR FLOT2 GOLGB1 MALL NCK1 RASA1 SDCBP SNCA SRC	93 interacting genes: ABL1 AFAP1L2 ANXA6 APC APP AR ARHGAP1 ARHGAP5 AURKA AURKB BBS10 BCL10 BCR BIRC5 BMPR1A BUB1 CASP3 CASP7 CAV2 CD5 CDKN2A CSF1R CSK DCC DLC1 DNAJA3 DOK1 DOK2 DOK4 EGFR EIF1 EPHA2 EPHB2 EPHB3 ERBB2 ERBB3 ERBB4 EZH2 FES FGFR1 G3BP1 GAB1 GMCL1 GRB2 HCK HRAS HSPD1 HTT IGF1R INSR KDR KHDRBS1 KIT LCK LYN MAGI1 MAP4K4 MET MLH3 NCK1 NTRK1 OLIG1 PAG1 PDE6D PDGFRB PIK3R1 PMS2 PTK2B PTPRC PTPRJ PXN RAB5A RACK1 RAP1A RB1 SERPINA4 SHC1 SLC9A2 SMAD2 SOCS3 SPSB1 SRC STAU1 STK11 SYK SYN1 TRMT2A WWP1 WWP2 XRCC6 YES1 ZAP70 ZNF579
Entrez ID		858	5921
HPRD ID		03029	00745
Ensembl ID		ENSG00000105971	ENSG00000145715
Uniprot IDs		P51636 Q53X57	P20936 Q59GK3
PDB IDs			1WER 1WQ1 2GQI 2GSB 2J05 2J06 2M51 4FSS 6PXB 6PXC 6WAX 6WAY 8BOS 8DGQ 9BZ4
Enriched GO Terms of Interacting Partners?		Membrane Raft Protein Sequestering Activity Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of Primary Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Metabolic Process Protein Localization To Plasma Membrane Raft Negative Regulation Of Signaling Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process Regulation Of Locomotion Perinuclear Region Of Cytoplasm Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Apoptotic Signaling Pathway Ephrin Receptor Signaling Pathway Enzyme Binding Positive Regulation Of Intracellular Signal Transduction Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Calcium Ion Transmembrane Transport Focal Adhesion Regulation Of Dopamine Uptake Involved In Synaptic Transmission Signal Complex Assembly Protein Localization To Membrane Raft Positive Regulation Of MAPK Cascade Caveola Substrate-dependent Cell Migration, Cell Extension Positive Regulation Of Cellular Component Biogenesis ATPase Binding Regulation Of RNA Metabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of T Cell Activation Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Cell Migration Plasma Membrane Regulation Of Cell Migration Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To Growth Factor Stimulus	Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Protein Kinase Activity Cell Surface Receptor Signaling Pathway Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cellular Component Organization Regulation Of Signal Transduction Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Signal Transduction ATP Binding Protein Autophosphorylation Protein Phosphorylation Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization Phosphorylation Regulation Of Apoptotic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Intracellular Signal Transduction Nucleotide Binding Regulation Of Cell Population Proliferation Regulation Of Cell Adhesion SH2 Domain Binding Positive Regulation Of Cell Migration Protein Modification Process Positive Regulation Of Cell Motility Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Locomotion Developmental Process Positive Regulation Of Immune System Process Regulation Of Cell Motility Negative Regulation Of Programmed Cell Death Positive Regulation Of Cellular Component Biogenesis Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Cell Migration Receptor Complex Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Cell Population Proliferation Regulation Of Locomotion
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