CAV2 and DNAJA1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		CAV2	DNAJA1
Gene Name		caveolin 2	DnaJ (Hsp40) homolog, subfamily A, member 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Acrosomal Membrane Intracellular Nucleus Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Caveola Focal Adhesion Membrane Transport Vesicle Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytoplasmic Vesicle Protein Complex Membrane Raft Perinuclear Region Of Cytoplasm	Ubiquitin Ligase Complex Nucleus Mitochondrion Cytosol Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Cytoplasmic Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding D1 Dopamine Receptor Binding Protein Homodimerization Activity	G-protein Coupled Receptor Binding Protein Binding ATP Binding Hsp70 Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding Chaperone Binding
	Biological Process	Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Vesicle Fusion Mitochondrion Organization Endoplasmic Reticulum Organization Regulation Of Mitotic Nuclear Division Insulin Receptor Signaling Pathway Vesicle Organization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of GTPase Activity Vesicle Docking Skeletal Muscle Fiber Development Protein Oligomerization Positive Regulation Of Dopamine Receptor Signaling Pathway Caveola Assembly	Protein Folding Response To Unfolded Protein Spermatogenesis Response To Heat Sperm Motility Androgen Receptor Signaling Pathway Negative Regulation Of Protein Ubiquitination Protein Refolding DNA Damage Response, Detection Of DNA Damage Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity Regulation Of Protein Transport Protein Localization To Mitochondrion Toxin Transport
Pathways
Drugs
Diseases
GWAS		Glaucoma (primary open-angle) ( 20835238) PR interval ( 20062060)
Protein-Protein Interactions		11 interactors: CAV1 CSNK2A1 DNAJA1 DRD1 EGFR FLOT2 GOLGB1 MALL NCK1 RASA1 SRC	20 interactors: ARL4D BCS1L BRCA1 CAV2 CD58 CDC16 CFTR ERG FZR1 HIVEP1 HMGCL HSPA8 LSM2 NELFCD NUDT3 PAXIP1 PTTG1 SUMO4 TM4SF1 TXN
Entrez ID		858	3301
HPRD ID		03029	04159
Ensembl ID		ENSG00000105971	ENSG00000086061
Uniprot IDs		P51636 Q53X57	P31689
PDB IDs			2LO1 2M6Y
Enriched GO Terms of Interacting Partners?		Locomotion Negative Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component Negative Regulation Of Cell Death Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Signaling Axon Guidance Regulation Of Apoptotic Process Cell Motility Negative Regulation Of Apoptotic Process Regulation Of Catalytic Activity Regulation Of Cell Death Negative Regulation Of Programmed Cell Death Neuron Development Axonogenesis Axon Development Negative Regulation Of Signal Transduction Cell Morphogenesis Involved In Neuron Differentiation Response To External Stimulus Chemotaxis Neuron Differentiation Neuron Projection Morphogenesis Regulation Of MAP Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signaling Cell Morphogenesis Involved In Differentiation Regulation Of Protein Kinase Activity Regulation Of Protein Metabolic Process Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Neuron Projection Development Negative Regulation Of Anoikis Signal Complex Assembly Regulation Of Phosphorus Metabolic Process Cell Migration Cell Projection Morphogenesis Cell Part Morphogenesis Negative Regulation Of Intracellular Signal Transduction Generation Of Neurons Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Anoikis Regulation Of Intracellular Transport Neurogenesis Astrocyte Development Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Intrinsic Apoptotic Signaling Pathway Gland Morphogenesis	Positive Regulation Of Protein Ubiquitination Regulation Of Protein Ubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of Histone Acetylation Regulation Of Histone H3-K4 Methylation Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Protein Acetylation Negative Regulation Of Cellular Metabolic Process Protein K11-linked Ubiquitination Nucleobase-containing Compound Metabolic Process Protein Polyubiquitination G2 DNA Damage Checkpoint Positive Regulation Of Histone Methylation Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Chromosome Organization Regulation Of Cell Cycle Process Positive Regulation Of Cellular Metabolic Process Regulation Of Histone Acetylation Positive Regulation Of Protein Modification Process Regulation Of Organelle Organization Regulation Of Cell Cycle Cellular Nitrogen Compound Metabolic Process Regulation Of Histone Methylation Cell Cycle Checkpoint Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H3-K36 Methylation Positive Regulation Of Voltage-gated Chloride Channel Activity Negative Regulation Of Fibril Organization Positive Regulation Of Histone H4-K16 Acetylation Diphosphoinositol Polyphosphate Catabolic Process Negative Regulation Of Potassium Ion Export Diadenosine Polyphosphate Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Division Proteasomal Protein Catabolic Process DNA Repair Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Protein Modification By Small Protein Conjugation Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Histone Modification Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Histone H3-K9 Acetylation Regulation Of Heart Rate By Hormone Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		3tau alpha1 alpha1b alpha2delta altogether auxiliary ba2 cavbeta channels clamp closer coexpression construct excitable facilitated gated mysterious physiology pore pscm138 pscm174 recording retained traffic trafficked tsa unidentified voltage	chaperone complement defective enlarged experimentally heat hsp hspa1a hspa6 hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1
Tagcloud (Difference) ?		3tau alpha1 alpha1b alpha2delta altogether auxiliary ba2 cavbeta channels clamp closer coexpression construct excitable facilitated gated mysterious physiology pore pscm138 pscm174 recording retained traffic trafficked tsa unidentified voltage	chaperone complement defective enlarged experimentally heat hsp hspa1a hspa6 hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1
Tagcloud (Intersection) ?