PRKRA and RB1

Number of citations of the paper that reports this interaction (PMID 9010216)
13

Data Source:
HPRD (in vivo, in vitro)

		PRKRA	RB1
Gene Name		protein kinase, interferon-inducible double stranded RNA dependent activator	retinoblastoma 1
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Membrane Perinuclear Region Of Cytoplasm	Chromatin Nucleus Nucleoplasm Spindle SWI/SNF Complex PML Body Rb-E2F Complex
	Molecular Function	Protein Binding Enzyme Activator Activity Protein Homodimerization Activity Poly(A) RNA Binding	Core Promoter Binding RNA Polymerase II Activating Transcription Factor Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Androgen Receptor Binding Phosphoprotein Binding
	Biological Process	Protein Phosphorylation Immune Response Negative Regulation Of Cell Proliferation Response To Virus Gene Expression Production Of SiRNA Involved In RNA Interference Cellular Response To Oxidative Stress Outer Ear Morphogenesis Middle Ear Morphogenesis Positive Regulation Of Catalytic Activity Skeletal System Morphogenesis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Cell Cycle Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Chromatin Remodeling Transcription, DNA-templated Negative Regulation Of Protein Kinase Activity Cell Cycle Arrest Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Mitotic Cell Cycle Checkpoint Ras Protein Signal Transduction Regulation Of Mitotic Cell Cycle Viral Process Androgen Receptor Signaling Pathway Sister Chromatid Biorientation Neuron Projection Development Maintenance Of Mitotic Sister Chromatid Cohesion Glial Cell Apoptotic Process Skeletal Muscle Cell Differentiation Neuron Maturation Enucleate Erythrocyte Differentiation Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Lipid Kinase Activity Myoblast Differentiation Positive Regulation Of Macrophage Differentiation Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Development Cell Morphogenesis Involved In Neuron Differentiation Negative Regulation Of Epithelial Cell Proliferation Striated Muscle Cell Differentiation Cell Division Neuron Apoptotic Process Protein Localization To Chromosome, Centromeric Region Regulation Of Cohesin Localization To Chromatin Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Centromere Complex Assembly Hepatocyte Apoptotic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Regulatory RNA pathways MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis	E2F mediated regulation of DNA replication DNA Damage/Telomere Stress Induced Senescence Synthesis of DNA Mitotic Prophase Cellular Senescence G1 Phase Regulation of DNA replication Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Orc1 removal from chromatin S Phase Cyclin E associated events during G1/S transition Cell Cycle, Mitotic M Phase Orc1 removal from chromatin Cyclin D associated events in G1 Formation of Senescence-Associated Heterochromatin Foci (SAHF) G1/S Transition Removal of licensing factors from origins Cyclin A:Cdk2-associated events at S phase entry Switching of origins to a post-replicative state Mitotic G1-G1/S phases Condensation of Prophase Chromosomes Inhibition of replication initiation of damaged DNA by RB1/E2F1
Drugs
Diseases
GWAS		Multiple sclerosis (OCB status) ( 23472185)
Protein-Protein Interactions		21 interactors: AGO2 CEBPZ COPS6 DICER1 EIF2AK2 GDF9 KIAA1377 LYAR NKRF POLR2G RABEPK RB1 SETDB1 SHC1 SNX5 TARBP2 TIRAP TP53 ZFP28 ZMAT3 ZNF746	167 interactors: AATF ABL1 AHR AR ARID3B ATF2 BAG1 BDP1 BNC2 BRCA1 BRF1 CASP10 CASP2 CASP3 CASP6 CASP7 CASP8 CASP9 CBX1 CBX4 CCNA1 CCNA2 CCNB1 CCNC CCND1 CCND2 CCND3 CCNE1 CCNT2 CDC27 CDK1 CDK14 CDK2 CDK3 CDK4 CDK5 CDK6 CDK9 CDKN1A CDKN1C CEBPA CEBPB CEBPD CEBPE CHEK1 CREG1 CTBP1 CUX1 DGKZ DNMT1 DNMT3A DYRK1A E2F1 E2F2 E2F3 E2F4 E4F1 EID1 ELF1 ENC1 EP300 FOS FRK GNB2L1 GTF3C2 HBP1 HDAC1 HDAC3 HIF1A HMGA2 HMGB1 HSPA8 ID2 INS IRF3 JUN KAT2B KAT5 KDM4A KDM5A KDM5B L3MBTL1 LIN54 LIN9 LMNA MAPK1 MAPK9 MCM7 MDM2 MDM4 MNAT1 MNDA MORF4L1 MORF4L2 MRPS18B MYC MYOD1 NCOA6 NDC80 NEFM PA2G4 PAX2 PAX5 PAX6 PELP1 PHB PIK3R1 PIK3R3 PLA2G12A PML POLA1 PPARG PPIA PPP1CA PPP1CB PPP1CC PRDM2 PRKCB PRKRA PRMT2 PSMD10 PURA RAF1 RBAK RBBP4 RBBP5 RBBP7 RBBP8 RBBP9 RING1 RINT1 RNF40 RUNX2 SERPINB2 SKP2 SMARCA4 SMARCB1 SMYD2 SNAPC1 SNAPC3 SNW1 SP1 SP3 SPI1 SPIB STAT3 SUMO1 SUMO2 SUV39H1 SUV420H2 TAF1 TBP TFAP2A TGM2 THOC1 TMPO TOP2A TRAP1 TRIM27 TRIP11 UBE2I UBTF UHRF2 USP4 USP7 VDR ZBTB16
Entrez ID		8575	5925
HPRD ID		04573	01574
Ensembl ID		ENSG00000180228	ENSG00000139687
Uniprot IDs		B4DJC7 O75569	P06400
PDB IDs		2DIX	1AD6 1GH6 1GUX 1H25 1N4M 1O9K 1PJM 2AZE 2QDJ 2R7G 3N5U 3POM 4ELJ 4ELL
Enriched GO Terms of Interacting Partners?		RNA Interference Pre-miRNA Processing Production Of MiRNAs Involved In Gene Silencing By MiRNA Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Posttranscriptional Regulation Of Gene Expression RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Gene Silencing By MiRNA Targeting Of MRNA For Destruction Involved In RNA Interference Cellular Response To DsRNA Regulation Of Gene Expression Posttranscriptional Gene Silencing Gene Expression Production Of SiRNA Involved In RNA Interference Regulation Of Transcription, DNA-templated Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Viral Process Negative Regulation Of Biosynthetic Process RNA Biosynthetic Process Gene Silencing By RNA Glial Cell Apoptotic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Response To DsRNA Regulation Of Viral Genome Replication Regulation Of Protein Metabolic Process Regulation Of Translational Initiation Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of MRNA 3'-end Processing Gene Silencing Regulation Of Translation Viral Process Regulation Of Metabolic Process Regulation Of MRNA 3'-end Processing ER-nucleus Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Growth Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation	Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Cell Cycle Negative Regulation Of Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Cell Cycle RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Cellular Metabolic Process Biosynthetic Process Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Modification Cellular Response To Stress Cell Cycle Process Chromatin Organization Mitotic Cell Cycle Process Regulation Of Protein Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Cellular Response To DNA Damage Stimulus Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Phase Transition
Tagcloud ?		1q21 5q31 6p21 alleles anxa6 applicable atopic conduct dermatitis direction exclusive histocompatibility immunochip influencing loci methodologies mutually opposing overlap overlapping pleiotropic psoriasis rarely shared th2 tnip1 traits unreported utilizing	13q14 16q22 18q21 1p35 22p 22q 3p22 5q21 8p 9p21 apc cent crc crcs dcc dukes existed frequencies heterozygosity loh microsatellite pairwise q14 q22 rer sporadic ucacrc ucacrcs ulcerative
Tagcloud (Difference) ?		1q21 5q31 6p21 alleles anxa6 applicable atopic conduct dermatitis direction exclusive histocompatibility immunochip influencing loci methodologies mutually opposing overlap overlapping pleiotropic psoriasis rarely shared th2 tnip1 traits unreported utilizing	13q14 16q22 18q21 1p35 22p 22q 3p22 5q21 8p 9p21 apc cent crc crcs dcc dukes existed frequencies heterozygosity loh microsatellite pairwise q14 q22 rer sporadic ucacrc ucacrcs ulcerative
Tagcloud (Intersection) ?