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PRKRA and TIRAP
Number of citations of the paper that reports this interaction (PubMedID
11526399
)
0
Data Source:
HPRD
(in vivo)
PRKRA
TIRAP
Description
protein activator of interferon induced protein kinase EIF2AK2
TIR domain containing adaptor protein
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Membrane
RISC Complex
Perinuclear Region Of Cytoplasm
RISC-loading Complex
Cytoplasm
Cytosol
Plasma Membrane
Cell Surface
Membrane
Endocytic Vesicle
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Ruffle Membrane
Molecular Function
RNA Binding
Double-stranded RNA Binding
Protein Binding
Enzyme Activator Activity
Enzyme Binding
Protein Kinase Activator Activity
SiRNA Binding
Identical Protein Binding
Protein Homodimerization Activity
Pre-miRNA Binding
Protein Kinase C Binding
Protein Binding
Phosphatidylinositol-4,5-bisphosphate Binding
Protein-macromolecule Adaptor Activity
Signaling Adaptor Activity
Toll-like Receptor 4 Binding
Toll-like Receptor 2 Binding
Identical Protein Binding
Molecular Adaptor Activity
Biological Process
Immune Response
Negative Regulation Of Cell Population Proliferation
Response To Virus
SiRNA Processing
Regulatory NcRNA-mediated Gene Silencing
Pre-miRNA Processing
Cellular Response To Oxidative Stress
MiRNA Processing
Outer Ear Morphogenesis
Middle Ear Morphogenesis
Ear Development
Skeletal System Morphogenesis
Protein Stabilization
Regulation Of Regulatory NcRNA Processing
RISC Complex Assembly
Antiviral Innate Immune Response
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Immune System Process
MyD88-dependent Toll-like Receptor Signaling Pathway
Inflammatory Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
Myeloid Cell Differentiation
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Protein-containing Complex Assembly
Response To Lipopolysaccharide
Regulation Of Interferon-beta Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-15 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Toll-like Receptor 2 Signaling Pathway
Positive Regulation Of Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Toll-like Receptor 4 Signaling Pathway
TIRAP-dependent Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Regulation Of Innate Immune Response
Positive Regulation Of JNK Cascade
Defense Response To Gram-positive Bacterium
Positive Regulation Of ERK1 And ERK2 Cascade
3'-UTR-mediated MRNA Stabilization
Cellular Response To Bacterial Lipopeptide
Cellular Response To Lipoteichoic Acid
Positive Regulation Of Neutrophil Chemotaxis
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways
MicroRNA (miRNA) biogenesis
Small interfering RNA (siRNA) biogenesis
PKR-mediated signaling
ER-Phagosome pathway
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Drugs
Diseases
Primary torsion dystonia (PTD)
GWAS
Inflammatory skin disease (
25574825
)
Multiple sclerosis (OCB status) (
23472185
)
Rapid functional decline in sporadic amyotrophic lateral sclerosis (
26746183
)
Blood protein levels (
30072576
)
Blood protein levels in cardiovascular risk (
28369058
)
Eosinophil percentage of granulocytes (
27863252
)
Neutrophil percentage of granulocytes (
27863252
)
Interacting Genes
29 interacting genes:
ADARB1
AGO2
CEBPZ
CEP126
COPS6
DICER1
EHHADH
EIF2AK2
GDF9
H19
LNX1
LYAR
NEIL3
NKRF
PIAS2
PNPT1
POLR2G
RABEPK
RB1
RBPMS
SETDB1
SHC1
SNX5
TARBP2
TIRAP
TP53
ZFP28
ZMAT3
ZNF746
25 interacting genes:
APP
ARAF
BTK
CASP1
CCDC47
CD247
DNAJC3
EIF2AK2
IL1RL1
IRAK2
IRAK4
LRRK1
LTN1
MPP3
MYD88
PCNA
PRKRA
SAMHD1
SOCS1
TICAM1
TICAM2
TLR2
TLR4
TRAF6
TRAM1
Entrez ID
8575
114609
HPRD ID
04573
05878
Ensembl ID
ENSG00000180228
ENSG00000150455
Uniprot IDs
A0A7I2V2I8
A0A7I2V5H3
B4DJC7
O75569
P58753
PDB IDs
2DIX
2NDH
2Y92
3UB2
3UB3
3UB4
4FZ5
4LQD
5T7Q
5UZB
8JZM
Enriched GO Terms of Interacting Partners
?
Double-stranded RNA Binding
RISC-loading Complex
SiRNA Processing
RISC Complex Assembly
SiRNA Binding
Negative Regulation Of Macromolecule Metabolic Process
Pre-miRNA Processing
Positive Regulation Of RNA Metabolic Process
Negative Regulation Of Glial Cell Proliferation
Negative Regulation Of Metabolic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Global Gene Silencing By MRNA Cleavage
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Nucleic Acid Binding
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
RNA Binding
Positive Regulation Of Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism
Regulation Of Macromolecule Metabolic Process
Glial Cell Apoptotic Process
Positive Regulation Of Macromolecule Metabolic Process
MiRNA Processing
Regulation Of Gene Expression
MiRNA Binding
Negative Regulation Of Gene Expression
Positive Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Gliogenesis
Regulation Of Glial Cell Proliferation
Identical Protein Binding
Pre-miRNA Binding
Positive Regulation Of Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Post-transcriptional Regulation Of Gene Expression
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Metabolic Process
Nucleoplasm
Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening
Receptor Tyrosine Kinase Binding
Negative Regulation Of Catalytic Activity
Negative Regulation Of Phosphate Metabolic Process
Regulation Of MiRNA Processing
Regulation Of Regulatory NcRNA Processing
Toll-like Receptor Signaling Pathway
Cell Surface Toll-like Receptor Signaling Pathway
Cell Surface Pattern Recognition Receptor Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Innate Immune Response-activating Signaling Pathway
Positive Regulation Of Chemokine Production
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Lipopolysaccharide-mediated Signaling Pathway
Activation Of Innate Immune Response
Toll-like Receptor 4 Signaling Pathway
Regulation Of Innate Immune Response
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Defense Response
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune Response-activating Signaling Pathway
Regulation Of Chemokine Production
Defense Response
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
Regulation Of Immune Response
Positive Regulation Of Innate Immune Response
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Immune System Process
Regulation Of Defense Response
Innate Immune Response
Positive Regulation Of Type I Interferon Production
Positive Regulation Of Cytokine Production
Response To Other Organism
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Intracellular Signal Transduction
Immune Response
Defense Response To Symbiont
Defense Response To Virus
Defense Response To Other Organism
Interleukin-33-mediated Signaling Pathway
Immune System Process
Interleukin-1-mediated Signaling Pathway
Regulation Of Cytokine Production
Regulation Of Immune System Process
Response To External Biotic Stimulus
Response To Stress
Regulation Of Type I Interferon Production
Positive Regulation Of Immune Response
TRIF-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Interleukin-6 Production
Response To Virus
MyD88-independent Toll-like Receptor Signaling Pathway
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