PRKRA and ZMAT3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		PRKRA	ZMAT3
Description		protein activator of interferon induced protein kinase EIF2AK2	zinc finger matrin-type 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane RISC Complex Perinuclear Region Of Cytoplasm RISC-loading Complex	Nucleus Nucleoplasm Nucleolus Plasma Membrane
	Molecular Function	RNA Binding Double-stranded RNA Binding Protein Binding Enzyme Activator Activity Enzyme Binding Protein Kinase Activator Activity SiRNA Binding Identical Protein Binding Protein Homodimerization Activity Pre-miRNA Binding	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Immune Response Negative Regulation Of Cell Population Proliferation Response To Virus SiRNA Processing Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing Cellular Response To Oxidative Stress MiRNA Processing Outer Ear Morphogenesis Middle Ear Morphogenesis Ear Development Skeletal System Morphogenesis Protein Stabilization Regulation Of Regulatory NcRNA Processing RISC Complex Assembly Antiviral Innate Immune Response Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Apoptotic Process DNA Damage Response Protein Transport
Pathways		MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis PKR-mediated signaling
Drugs
Diseases		Primary torsion dystonia (PTD)
GWAS		Inflammatory skin disease ( 25574825) Multiple sclerosis (OCB status) ( 23472185) Rapid functional decline in sporadic amyotrophic lateral sclerosis ( 26746183)	Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Platelet count ( 27863252) Platelet distribution width ( 32888494) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) Refractive error ( 32231278)
Interacting Genes		29 interacting genes: ADARB1 AGO2 CEBPZ CEP126 COPS6 DICER1 EHHADH EIF2AK2 GDF9 H19 LNX1 LYAR NEIL3 NKRF PIAS2 PNPT1 POLR2G RABEPK RB1 RBPMS SETDB1 SHC1 SNX5 TARBP2 TIRAP TP53 ZFP28 ZMAT3 ZNF746	6 interacting genes: APP PRKRA SIAH1 STAU1 SUMO2 TARBP2
Entrez ID		8575	64393
HPRD ID		04573	07343
Ensembl ID		ENSG00000180228	ENSG00000172667
Uniprot IDs		A0A7I2V2I8 A0A7I2V5H3 B4DJC7 O75569	Q9HA38
PDB IDs		2DIX
Enriched GO Terms of Interacting Partners?		Double-stranded RNA Binding RISC-loading Complex SiRNA Processing RISC Complex Assembly SiRNA Binding Negative Regulation Of Macromolecule Metabolic Process Pre-miRNA Processing Positive Regulation Of RNA Metabolic Process Negative Regulation Of Glial Cell Proliferation Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Global Gene Silencing By MRNA Cleavage Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleic Acid Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process RNA Binding Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism Regulation Of Macromolecule Metabolic Process Glial Cell Apoptotic Process Positive Regulation Of Macromolecule Metabolic Process MiRNA Processing Regulation Of Gene Expression MiRNA Binding Negative Regulation Of Gene Expression Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gliogenesis Regulation Of Glial Cell Proliferation Identical Protein Binding Pre-miRNA Binding Positive Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Post-transcriptional Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Nucleoplasm Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Receptor Tyrosine Kinase Binding Negative Regulation Of Catalytic Activity Negative Regulation Of Phosphate Metabolic Process Regulation Of MiRNA Processing Regulation Of Regulatory NcRNA Processing	Double-stranded RNA Binding RISC-loading Complex RISC Complex Assembly SiRNA Processing Pre-miRNA Binding SiRNA Binding Pre-miRNA Processing Regulation Of Regulatory NcRNA Processing Positive Regulation Of Apoptotic Signaling Pathway Regulatory NcRNA-mediated Gene Silencing Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Long-term Synaptic Potentiation Amyloid Fibril Formation Positive Regulation Of Viral Genome Replication MiRNA Processing Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Viral Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Enzyme Binding Amyloid-beta Complex Growth Cone Lamellipodium Axo-dendritic Transport Negative Regulation Of Gene Expression Regulation Of Response To Calcium Ion Cell Body Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Viral Genome Replication Regulation Of SiRNA Processing RISC Complex Reproductive Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Viral Life Cycle Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Post-transcriptional Regulation Of Gene Expression Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Synaptic Transmission Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization RNA Binding
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